teg-4 Splicing factor 3B subunit 3 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: teg-4
Gene description: Splicing factor 3B subunit 3
Primary source: WormBase:WBGene00019323
Locus tag: CELE_K02F2.3
See related: AllianceGenome:WB:WBGene00019323
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable U2 snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U2 snRNP. Predicted to be active in nucleus. Orthologous to human SF3B3 (splicing factor 3b subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See teg-4 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 22

Sequence:: Chromosome: I; NC_003279.8 (6814511..6834699)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A reduction in teg-4 activity reduces the splicing efficiency of targets involved in controlling the balance between proliferation and differentiation.
Title: A mutation in teg-4, which encodes a protein homologous to the SAP130 pre-mRNA splicing factor, disrupts the balance between proliferation and differentiation in the C. elegans germ line.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K02F2.3 (e-PCR)
- UniSTS:311372

K02F2.4 (e-PCR)
- UniSTS:311373

K02F2.6 (e-PCR)
- UniSTS:306632

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables U2 snRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of U2 snRNP	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Splicing factor 3B subunit 3

NP_491953.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

6814511..6834699

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059552.4 → NP_491953.1 Splicing factor 3B subunit 3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491953.1

Status: REVIEWED

UniProtKB/TrEMBL

O44985

Conserved Domains (2) summary

pfam03178
Location:857 → 1185

CPSF_A; CPSF A subunit region

pfam10433
Location:77 → 591

MMS1_N; Mono-functional DNA-alkylating methyl methanesulfonate N-term