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acdh-12 Very long-chain specific acyl-CoA dehydrogenase, mitochondrial [ Caenorhabditis elegans ]

Gene ID: 174180, updated on 25-Jan-2024

Summary

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Gene symbol
acdh-12
Gene description
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial
Primary source
WormBase:WBGene00017125
Locus tag
CELE_E04F6.5
See related
AllianceGenome:WB:WBGene00017125
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable fatty-acyl-CoA binding activity and very-long-chain-acyl-CoA dehydrogenase activity. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in very long chain acyl-CoA dehydrogenase deficiency. Orthologous to human ACADVL (acyl-CoA dehydrogenase very long chain). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
8
Sequence:
Chromosome: II; NC_003280.10 (7192434..7194770, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Phosphodiesterase delta-like protein Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene PLD phosphodiesterase domain-containing protein Neighboring gene ncRNA Neighboring gene MaoC-like domain-containing protein Neighboring gene Secreted protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Purification, crystallization and preliminary crystallographic analysis of very-long-chain acyl-CoA dehydrogenase from Caenorhabditis elegans. Li Z, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 Apr 1. PMID 20383014, Free PMC Article
  2. Identification of a novel mitochondrial complex I assembly factor ACDH-12 in Caenorhabditis elegans. Chuaijit S, et al. Mitochondrion, 2019 May. PMID 29540318
  3. A Caenorhabditis elegans nutrient response system partially dependent on nuclear receptor NHR-49. Van Gilst MR, et al. Proc Natl Acad Sci U S A, 2005 Sep 20. PMID 16157872, Free PMC Article
  4. Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans. Gottschalk A, et al. EMBO J, 2005 Jul 20. PMID 15990870, Free PMC Article
  5. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The authors demonstrate for the first time that a deficiency of ACDH-12 affects the formation and function of complex I. They suggest that in Caenorhabditis elegans, ACDH-12 is required for the assembly of the respiratory complex I, but may not be crucial to fatty acid oxidation.
    Title: Identification of a novel mitochondrial complex I assembly factor ACDH-12 in Caenorhabditis elegans.
  2. Purified very-long-chain acyl-CoA dehydrogenase (12 mg ml(-1)) was successfully crystallized by the hanging-drop vapour-diffusion method under conditions containing 100 mM Tris-HCl pH 8.0, 150 mM sodium chloride, 200 mM magnesium formate and 13% PEG 3350.
    Title: Purification, crystallization and preliminary crystallographic analysis of very-long-chain acyl-CoA dehydrogenase from Caenorhabditis elegans.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables fatty-acyl-CoA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-CH group of donors IEA
Inferred from Electronic Annotation
more info
  
enables very-long-chain fatty acyl-CoA dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial
NP_001022062.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    7192434..7194770 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026891.7 → NP_001022062.1  Very long-chain specific acyl-CoA dehydrogenase, mitochondrial [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022062.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q19057
    Conserved Domains (2) summary
    cd01161
    Location:41 → 449
    VLCAD; Very long chain acyl-CoA dehydrogenase
    COG1960
    Location:61 → 441
    CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]

RNA

  1. NR_151558.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
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