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agl-1 Glycogen debranching enzyme [ Caenorhabditis elegans ]

Gene ID: 175091, updated on 23-Nov-2023

Summary

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Gene symbol
agl-1
Gene description
Glycogen debranching enzyme
Primary source
WormBase:WBGene00011050
Locus tag
CELE_R06A4.8
See related
AllianceGenome:WB:WBGene00011050
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable 4-alpha-glucanotransferase activity and amylo-alpha-1,6-glucosidase activity. Predicted to be involved in glycogen catabolic process. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in glycogen storage disease III. Orthologous to human AGL (amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See agl-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
11
Sequence:
Chromosome: II; NC_003280.10 (14350713..14358113, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene FeS cluster biogenesis domain-containing protein Neighboring gene Protein lin-7 homolog Neighboring gene L51_S25_CI-B8 domain-containing protein Neighboring gene Transcription elongation factor 1 homolog Neighboring gene pre-mRNA 3' end processing protein pfs-2 Neighboring gene SPK domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Deficiency of α-glucosidase I alters glycoprotein glycosylation and lifespan in Caenorhabditis elegans. Katoh T, et al. Glycobiology, 2013 Oct. PMID 23836288, Free PMC Article
  2. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article
  3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Agl1 deficient animals have reduced lifespan and dramatic increase of glucosylated oligomannose glycans.
    Title: Deficiency of α-glucosidase I alters glycoprotein glycosylation and lifespan in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 4-alpha-glucanotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 4-alpha-glucanotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables amylo-alpha-1,6-glucosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables amylo-alpha-1,6-glucosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables beta-maltose 4-alpha-glucanotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycogen catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycogen catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Glycogen debranching enzyme
NP_496984.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    14350713..14358113 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064583.6 → NP_496984.1  Glycogen debranching enzyme [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496984.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O62334
    Conserved Domains (5) summary
    cd11327
    Location:93 → 574
    AmyAc_Glg_debranch_2; Alpha amylase catalytic domain found in glycogen debranching enzymes
    TIGR01531
    Location:22 → 1462
    glyc_debranch; glycogen debranching enzymye
    pfam06202
    Location:998 → 1457
    GDE_C; Amylo-alpha-1,6-glucosidase
    pfam14699
    Location:31 → 105
    hGDE_N; N-terminal domain from the human glycogen debranching enzyme
    pfam14702
    Location:682 → 931
    hGDE_central; central domain of human glycogen debranching enzyme
Nucleotide Protein
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