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ddx-15 Pre-mRNA-splicing factor ATP-dependent RNA helicase ddx-15;RNA helicase [ Caenorhabditis elegans ]

Gene ID: 175771, updated on 23-Nov-2023

Summary

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Gene symbol
ddx-15
Gene description
Pre-mRNA-splicing factor ATP-dependent RNA helicase ddx-15;RNA helicase
Primary source
WormBase:WBGene00018967
Locus tag
CELE_F56D2.6
See related
AllianceGenome:WB:WBGene00018967
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA binding activity and RNA helicase activity. Predicted to be involved in rRNA processing. Predicted to be located in nucleus. Predicted to be part of spliceosomal complex. Orthologous to human DHX15 (DEAH-box helicase 15). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ddx-15 in Genome Data Viewer
Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (5589036..5591718, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene UBC core domain-containing protein Neighboring gene DUF148 domain-containing protein Neighboring gene RBR-type E3 ubiquitin transferase Neighboring gene Cytochrome b-c1 complex subunit 1, mitochondrial;Peptidase M16 C-terminal domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RNA-interacting proteins act as site-specific repressors of ADAR2-mediated RNA editing and fluctuate upon neuronal stimulation. Tariq A, et al. Nucleic Acids Res, 2013 Feb 1. PMID 23275536, Free PMC Article
  2. Multiple ERK substrates execute single biological processes in Caenorhabditis elegans germ-line development. Arur S, et al. Proc Natl Acad Sci U S A, 2009 Mar 24. PMID 19264959, Free PMC Article
  3. The RNA-binding protein repertoire of Arabidopsis thaliana. Marondedze C, et al. Sci Rep, 2016 Jul 11. PMID 27405932, Free PMC Article
  4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA processing ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Pre-mRNA-splicing factor ATP-dependent RNA helicase ddx-15;RNA helicase
NP_741147.1
  • Confirmed by transcript evidence
NP_741148.2
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    5589036..5591718 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171130.5 → NP_741147.1  Pre-mRNA-splicing factor ATP-dependent RNA helicase ddx-15 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741147.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20875
    Conserved Domains (6) summary
    smart00490
    Location:327 → 419
    HELICc; helicase superfamily c-terminal domain
    smart00487
    Location:70 → 266
    DEXDc; DEAD-like helicases superfamily
    smart00847
    Location:489 → 572
    HA2; Helicase associated domain (HA2) Add an annotation
    cd00046
    Location:95 → 239
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cl22853
    Location:41 → 106
    Motor_domain; Myosin and Kinesin motor domain
    pfam07717
    Location:607 → 709
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

  2. NM_171131.10 → NP_741148.2  RNA helicase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741148.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G8JY03
    Conserved Domains (6) summary
    smart00490
    Location:327 → 419
    HELICc; helicase superfamily c-terminal domain
    smart00487
    Location:70 → 266
    DEXDc; DEAD-like helicases superfamily
    smart00847
    Location:489 → 572
    HA2; Helicase associated domain (HA2) Add an annotation
    cd00046
    Location:95 → 239
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cl22853
    Location:41 → 106
    Motor_domain; Myosin and Kinesin motor domain
    pfam07717
    Location:607 → 700
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q20875.1

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