rpt-3 putative 26S proteasome regulatory subunit 6B [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: rpt-3
Gene description: putative 26S proteasome regulatory subunit 6B
Primary source: WormBase:WBGene00004503
Locus tag: CELE_F23F12.6
See related: AllianceGenome:WB:WBGene00004503
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable proteasome-activating activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be part of proteasome regulatory particle, base subcomplex. Is expressed in several structures, including enteric muscle; nervous system; pharyngeal-intestinal valve; pharynx; and reproductive system. Orthologous to human PSMC4 (proteasome 26S subunit, ATPase 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See rpt-3 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 3

Sequence:: Chromosome: III; NC_003281.10 (6489793..6491282)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F23F12.7 (e-PCR)
- UniSTS:321126

F23F12.6 (e-PCR)
- UniSTS:309916

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables proteasome-activating activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in positive regulation of proteasomal protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of proteasome complex	IEA Inferred from Electronic Annotation more info
part_of proteasome regulatory particle, base subcomplex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: putative 26S proteasome regulatory subunit 6B

NP_498429.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

6489793..6491282

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066028.5 → NP_498429.1 putative 26S proteasome regulatory subunit 6B [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498429.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P46502

Conserved Domains (2) summary

PTZ00454
Location:35 → 414

PTZ00454; 26S protease regulatory subunit 6B-like protein; Provisional

pfam00004
Location:198 → 331

AAA; ATPase family associated with various cellular activities (AAA)