rpn-3 26S proteasome non-ATPase regulatory subunit 3 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: rpn-3
Gene description: 26S proteasome non-ATPase regulatory subunit 3
Primary source: WormBase:WBGene00004460
Locus tag: CELE_C30C11.2
See related: AllianceGenome:WB:WBGene00004460
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable enzyme regulator activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome regulatory particle, lid subcomplex. Is expressed in several structures, including body wall musculature; intestine; nervous system; rectal gland cell; and tail. Orthologous to human PSMD3 (proteasome 26S subunit, non-ATPase 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: III

Exon count:: 4

Sequence:: Chromosome: III; NC_003281.10 (8447353..8449346)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C30C11.2 (e-PCR)
- UniSTS:308668

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables enzyme regulator activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in programmed cell death involved in cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of proteasome complex	IEA Inferred from Electronic Annotation more info
part_of proteasome regulatory particle, lid subcomplex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 26S proteasome non-ATPase regulatory subunit 3

NP_498869.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

8447353..8449346

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066468.5 → NP_498869.1 26S proteasome non-ATPase regulatory subunit 3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498869.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q04908

Conserved Domains (2) summary

pfam01399
Location:327 → 419

PCI; PCI domain

pfam08375
Location:437 → 494

Rpn3_C; Proteasome regulatory subunit C-terminal