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cpf-2 RRM domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 176742, updated on 23-Nov-2023

Summary

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Gene symbol
cpf-2
Gene description
RRM domain-containing protein
Primary source
WormBase:WBGene00000774
Locus tag
CELE_F56A8.6
See related
AllianceGenome:WB:WBGene00000774
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in pre-mRNA cleavage required for polyadenylation. Located in nuclear speck. Orthologous to several human genes including CSTF2 (cleavage stimulation factor subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (13266932..13268883, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Leucine-rich repeat domain, L domain-like;Transmembrane protein Neighboring gene F-box domain-containing protein Neighboring gene F-box domain-containing protein Neighboring gene ncRNA Neighboring gene Syntaxin-1A homolog Neighboring gene Histone-lysine N-methyltransferase set-25

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nuclear pre-mRNA 3'-end processing regulates synapse and axon development in C. elegans. Van Epps H, et al. Development, 2010 Jul. PMID 20530551, Free PMC Article
  2. An evolutionarily conserved role for SRm160 in 3'-end processing that functions independently of exon junction complex formation. McCracken S, et al. J Biol Chem, 2003 Nov 7. PMID 12944400
  3. Genes involved in pre-mRNA 3'-end formation and transcription termination revealed by a lin-15 operon Muv suppressor screen. Cui M, et al. Proc Natl Acad Sci U S A, 2008 Oct 28. PMID 18946043, Free PMC Article
  4. Functional genomic analysis of RNA interference in C. elegans. Kim JK, et al. Science, 2005 May 20. PMID 15790806
  5. The Caenorhabditis elegans RDE-10/RDE-11 complex regulates RNAi by promoting secondary siRNA amplification. Zhang C, et al. Curr Biol, 2012 May 22. PMID 22542102, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA 3'-end processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of mRNA cleavage and polyadenylation specificity factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RRM domain-containing protein
NP_499734.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    13266932..13268883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067333.5 → NP_499734.1  RRM domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499734.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O45577
    Conserved Domains (3) summary
    cd12398
    Location:20 → 94
    RRM_CSTF2_RNA15_like; RNA recognition motif in cleavage stimulation factor subunit 2 (CSTF2), yeast ortholog mRNA 3'-end-processing protein RNA15 and similar proteins
    pfam14304
    Location:299 → 334
    CSTF_C; Transcription termination and cleavage factor C-terminal
    pfam14327
    Location:115 → 194
    CSTF2_hinge; Hinge domain of cleavage stimulation factor subunit 2
Nucleotide Protein
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