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rpn-1 26S proteasome non-ATPase regulatory subunit 2 [ Caenorhabditis elegans ]

Gene ID: 177455, updated on 11-Apr-2024

Summary

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Gene symbol
rpn-1
Gene description
26S proteasome non-ATPase regulatory subunit 2
Primary source
WormBase:WBGene00004458
Locus tag
CELE_T22D1.9
See related
AllianceGenome:WB:WBGene00004458
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable enzyme regulator activity. Involved in nematode larval development and reproduction. Predicted to be part of proteasome regulatory particle, base subcomplex. Predicted to be active in nucleus and proteasome storage granule. Orthologous to human PSMD2 (proteasome 26S subunit ubiquitin receptor, non-ATPase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See rpn-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
7
Sequence:
Chromosome: IV; NC_003282.8 (6906420..6909913, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene SRCR domain-containing protein Neighboring gene EF-hand domain-containing protein Neighboring gene Col_cuticle_N domain-containing protein Neighboring gene ncRNA Neighboring gene Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Symmetrically dividing cell specific division axes alteration observed in proteasome depleted C. elegans embryo. Sugiyama Y, et al. Mech Dev, 2008 Aug. PMID 18502617
  2. Proteasomal ubiquitin receptor RPN-10 controls sex determination in Caenorhabditis elegans. Shimada M, et al. Mol Biol Cell, 2006 Dec. PMID 17050737, Free PMC Article
  3. Endoplasmic reticulum-associated SKN-1A/Nrf1 mediates a cytoplasmic unfolded protein response and promotes longevity. Lehrbach NJ, et al. Elife, 2019 Apr 11. PMID 30973820, Free PMC Article
  4. skn-1-Dependent and -independent regulation of aip-1 expression following metabolic stress in Caenorhabditis elegans. Ferguson AA, et al. Mol Cell Biol, 2010 Jun. PMID 20351174, Free PMC Article
  5. Proteasomal dysfunction activates the transcription factor SKN-1 and produces a selective oxidative-stress response in Caenorhabditis elegans. Kahn NW, et al. Biochem J, 2008 Jan 1. PMID 17714076

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables enzyme regulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in reproductive process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome accessory complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome regulatory particle, base subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome regulatory particle, base subcomplex IEA
Inferred from Electronic Annotation
more info
  
is_active_in proteasome storage granule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
26S proteasome non-ATPase regulatory subunit 2
NP_501064.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    6906420..6909913 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068663.6 → NP_501064.1  26S proteasome non-ATPase regulatory subunit 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501064.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GZH5
    Conserved Domains (2) summary
    COG5110
    Location:23 → 972
    RPN1; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
    pfam01851
    Location:783 → 814
    PC_rep; Proteasome/cyclosome repeat
Nucleotide Protein
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