U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nat2 N-acetyltransferase 2 (arylamine N-acetyltransferase) [ Mus musculus (house mouse) ]

Gene ID: 17961, updated on 8-Feb-2024

Summary

Go to the top of the page Help
Official Symbol
Nat2provided by MGI
Official Full Name
N-acetyltransferase 2 (arylamine N-acetyltransferase)provided by MGI
Primary source
MGI:MGI:109201
See related
Ensembl:ENSMUSG00000051147 AllianceGenome:MGI:109201
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables arylamine N-acetyltransferase activity. Predicted to be located in cytosol. Is expressed in several structures, including adrenal gland; female reproductive system; respiratory system; spleen; and sympathetic ganglion. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); contact dermatitis (multiple); leukemia (multiple); and lung disease (multiple). Orthologous to several human genes including NAT1 (N-acetyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: Loci in other organisms that are functionally homologous to this one are validly referred to as both NAT1 and NAT2; i.e., the functional homologs of NAT1 include mouse and rat Nat2, while the functional homologs of human NAT2 include mouse and rat Nat1. Name:sequence associations are consistent with current use in the field. [13 Feb 2013]
Expression
Broad expression in liver E14 (RPKM 1.2), liver E14.5 (RPKM 0.9) and 24 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Nat2 in Genome Data Viewer
Location:
8 B3.2; 8 33.38 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (67947527..67955296)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (67494875..67502644)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24677 Neighboring gene STARR-seq mESC enhancer starr_21692 Neighboring gene STARR-positive B cell enhancer mm9_chr8:69955113-69955414 Neighboring gene STARR-seq mESC enhancer starr_21694 Neighboring gene STARR-seq mESC enhancer starr_21695 Neighboring gene N-acetyl transferase 1 Neighboring gene Tu translation elongation factor pseudogene Neighboring gene N-acetyltransferase 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Acute murine colitis reduces colonic 5-aminosalicylic acid metabolism by regulation of N-acetyltransferase-2. Ramírez-Alcántara V, et al. Am J Physiol Gastrointest Liver Physiol, 2014 Jun 1. PMID 24742986, Free PMC Article
  2. 5-methyl-tetrahydrofolate and the S-adenosylmethionine cycle in C57BL/6J mouse tissues: gender differences and effects of arylamine N-acetyltransferase-1 deletion. Witham KL, et al. PLoS One, 2013. PMID 24205029, Free PMC Article
  3. Characterisation of CpG methylation in the upstream control region of mouse Nat2: evidence for a gene-environment interaction in a polymorphic gene implicated in folate metabolism. Wakefield L, et al. Gene, 2010 Feb 15. PMID 20026257
  4. Mouse N-acetyltransferase type 2, the homologue of human N-acetyltransferase type 1. Kawamura A, et al. Biochem Pharmacol, 2008 Apr 1. PMID 18280460, Free PMC Article
  5. Confirmation of the role of N-acetyltransferase 2 in teratogen-induced cleft palate using transgenics and knockouts. Erickson RP, et al. Mol Reprod Dev, 2008 Jun. PMID 18161794

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. metabolic efficiency in arylamine N-acetyltransferase-deficient mice
    Title: A readout of metabolic efficiency in arylamine N-acetyltransferase-deficient mice reveals minor energy metabolism changes.
  2. miR-217 inhibits proliferation adn promotes apoptosis and autophagy in hepatocytes in CCL4-induced liver injury through targeting NAT2 expression.
    Title: Effects of microRNA-217 on proliferation, apoptosis, and autophagy of hepatocytes in rat models of CCL4-induced liver injury by targeting NAT2.
  3. This study illustrated that deficiency of NAT1/2 decreases isoniazid (INH) acetylation, but increases the interactions of INH with endobiotics in the liver.
    Title: Deficiency of N-acetyltransferase increases the interactions of isoniazid with endobiotics in mouse liver.
  4. It was concluded that an acute colonic inflammation impairs the expression and function of NAT2 enzyme, thereby diminishing the capacity for 5-aminosalisylic acid metabolism by colonic mucosa.
    Title: Acute murine colitis reduces colonic 5-aminosalicylic acid metabolism by regulation of N-acetyltransferase-2.
  5. Hyperhomocysteinemia-induced decrease of peroxynitrite level is associated with an increase of hepatic Nat2 isoform activity with a reversal effect of wine polyphenol extract supplementation.
    Title: Effect of red wine polyphenol dietary supplementation on two phase II enzymes in liver of hyperhomocysteinemic mice.
  6. Mouse NAT2 is likely to influence epigenetic gene control, particularly of its own locus, and this is consistent with recent evidence associating aberrant mouse Nat2/human NAT1 gene expression with certain developmental malformations and cancers.
    Title: Characterisation of CpG methylation in the upstream control region of mouse Nat2: evidence for a gene-environment interaction in a polymorphic gene implicated in folate metabolism.
  7. study reports the detailed expression of the Nat2 gene and encoded protein in mouse embryos
    Title: Mouse arylamine N-acetyltransferase 2 (Nat2) expression during embryogenesis: a potential marker for the developing neuroendocrine system.
  8. Mouse N-acetyltransferase-2 was produced as a recombinant protein and found to have a substrate specificity profile similar to human N-acetyltransferase type 1.
    Title: Mouse N-acetyltransferase type 2, the homologue of human N-acetyltransferase type 1.
  9. These ocular phenotypes and their association with Nat2 genotype indicate that the Nat2 locus may be responsible for the previously described microphthalmic Cat4 phenotype.
    Title: Ocular defects associated with a null mutation in the mouse arylamine N-acetyltransferase 2 gene.
  10. expression and down-regulation of this enzyme complex plays an important role in the generation and differentiation of neurons
    Title: An evolutionarily conserved N-terminal acetyltransferase complex associated with neuronal development.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables arylamine N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arylamine N-acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables arylamine N-acetyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables arylamine N-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
arylamine N-acetyltransferase 2
Names
N-acetyl transferase 2
N-acetyltransferase type 2
NAT-2
arylamide acetylase 2
NP_001162049.1
NP_035004.1
XP_006509655.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168577.1 → NP_001162049.1  arylamine N-acetyltransferase 2

    See identical proteins and their annotated locations for NP_001162049.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC122867, AK007583
    Consensus CDS
    CCDS22338.1
    UniProtKB/Swiss-Prot
    P50295
    UniProtKB/TrEMBL
    Q711M4, Q78ZC4, Q921E5
    Related
    ENSMUSP00000091181.6, ENSMUST00000093470.7
    Conserved Domains (1) summary
    pfam00797
    Location:20 → 280
    Acetyltransf_2; N-acetyltransferase

  2. NM_010874.3 → NP_035004.1  arylamine N-acetyltransferase 2

    See identical proteins and their annotated locations for NP_035004.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC122867, AK007583
    Consensus CDS
    CCDS22338.1
    UniProtKB/Swiss-Prot
    P50295
    UniProtKB/TrEMBL
    Q711M4, Q78ZC4, Q921E5
    Related
    ENSMUSP00000130065.2, ENSMUST00000163856.3
    Conserved Domains (1) summary
    pfam00797
    Location:20 → 280
    Acetyltransf_2; N-acetyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    67947527..67955296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509592.2 → XP_006509655.1  arylamine N-acetyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_006509655.1

    UniProtKB/TrEMBL
    Q921E5
    Conserved Domains (1) summary
    pfam00797
    Location:60 → 320
    Acetyltransf_2; N-acetyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50295.1 GenPept UniProtKB/Swiss-Prot:P50295

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous