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Ncoa2 nuclear receptor coactivator 2 [ Mus musculus (house mouse) ]

Gene ID: 17978, updated on 5-Mar-2024

Summary

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Official Symbol
Ncoa2provided by MGI
Official Full Name
nuclear receptor coactivator 2provided by MGI
Primary source
MGI:MGI:1276533
See related
Ensembl:ENSMUSG00000005886 AllianceGenome:MGI:1276533
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TIF2; Grip1; SRC-2; GRIP-1; KAT13C; NCoA-2; bHLHe75; D1Ertd433e
Summary
Enables several functions, including RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; chromatin binding activity; and nuclear receptor coactivator activity. Involved in circadian regulation of gene expression; locomotor rhythm; and regulation of glucose metabolic process. Acts upstream of or within several processes, including cellular response to Thyroglobulin triiodothyronine; regulation of transcription by RNA polymerase II; and response to progesterone. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system; and sensory organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human NCOA2 (nuclear receptor coactivator 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 10.9), thymus adult (RPKM 8.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ncoa2 in Genome Data Viewer
Location:
1 A3; 1 4.12 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (13209329..13444451, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (13139105..13374227, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00263 Neighboring gene predicted gene, 39592 Neighboring gene STARR-seq mESC enhancer starr_00267 Neighboring gene PR domain containing 14 Neighboring gene STARR-seq mESC enhancer starr_00268 Neighboring gene STARR-seq mESC enhancer starr_00269 Neighboring gene predicted gene, 23169 Neighboring gene STARR-positive B cell enhancer mm9_chr1:13362488-13362789 Neighboring gene STARR-positive B cell enhancer ABC_E9461 Neighboring gene predicted gene, 51852 Neighboring gene predicted gene, 39595 Neighboring gene signal recognition particle receptor ('docking protein') pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transient activation of AMPK preceding left ventricular pressure overload reduces adverse remodeling and preserves left ventricular function. Nam DH, et al. FASEB J, 2019 Jan. PMID 30024790, Free PMC Article
  2. SRC-2 orchestrates polygenic inputs for fine-tuning glucose homeostasis. Fleet T, et al. Proc Natl Acad Sci U S A, 2015 Nov 3. PMID 26487680, Free PMC Article
  3. A novel mutation of the hGR gene causing Chrousos syndrome. Nicolaides NC, et al. Eur J Clin Invest, 2015 Aug. PMID 26031419
  4. SRC-2 coactivator deficiency decreases functional reserve in response to pressure overload of mouse heart. Reineke EL, et al. PLoS One, 2012. PMID 23300926, Free PMC Article
  5. Role of transcriptional coregulator GRIP1 in the anti-inflammatory actions of glucocorticoids. Chinenov Y, et al. Proc Natl Acad Sci U S A, 2012 Jul 17. PMID 22753499, Free PMC Article

See all (145) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Steroid receptor coactivator-2 drives epithelial reprogramming that enables murine embryo implantation.
    Title: Steroid receptor coactivator-2 drives epithelial reprogramming that enables murine embryo implantation.
  2. Ncoa2 Promotes CD8+ T cell-Mediated Antitumor Immunity by Stimulating T-cell Activation via Upregulation of PGC-1alpha Critical for Mitochondrial Function.
    Title: Ncoa2 Promotes CD8+ T cell-Mediated Antitumor Immunity by Stimulating T-cell Activation via Upregulation of PGC-1α Critical for Mitochondrial Function.
  3. HEY1-NCOA2 expression modulates chondrogenic differentiation and induces mesenchymal chondrosarcoma in mice.
    Title: HEY1-NCOA2 expression modulates chondrogenic differentiation and induces mesenchymal chondrosarcoma in mice.
  4. SRC2 controls CD4[+] T cell activation via stimulating c-Myc-mediated upregulation of amino acid transporter Slc7a5.
    Title: SRC2 controls CD4(+) T cell activation via stimulating c-Myc-mediated upregulation of amino acid transporter Slc7a5.
  5. NCOA2 coordinates with the transcriptional KAT2B-NF-kappaB partner to trigger inflammation response in acute kidney injury.
    Title: NCOA2 coordinates with the transcriptional KAT2B-NF-κB partner to trigger inflammation response in acute kidney injury.
  6. Hypothalamic steroid receptor coactivator-2 regulates adaptations to fasting and overnutrition.
    Title: Hypothalamic steroid receptor coactivator-2 regulates adaptations to fasting and overnutrition.
  7. Transcription cofactor GRIP1 differentially affects myeloid cell-driven neuroinflammation and response to IFN-beta therapy.
    Title: Transcription cofactor GRIP1 differentially affects myeloid cell-driven neuroinflammation and response to IFN-β therapy.
  8. Results suggest that SRC-2 coordinates cardiomyocyte secretion of VEGF downstream of the two major angiogenic stimuli occurring during pressure overload bridging both hypertrophic and hypoxia-stimulated paracrine signaling.
    Title: Steroid receptor coactivator-2 (SRC-2) coordinates cardiomyocyte paracrine signaling to promote pressure overload-induced angiogenesis.
  9. studies demonstrate that SRC-2 provides an essential link between the behavioral activities influenced by light cues and the metabolic homeostasis maintained by the liver
    Title: Genetic and Environmental Models of Circadian Disruption Link SRC-2 Function to Hepatic Pathology.
  10. the expression of MOZ-TIF2 fusion protein represses the transcription of p16INK4a and p19ARF and blocks senescence.
    Title: Expression of the MOZ-TIF2 oncoprotein in mice represses senescence.
Submit: New GeneRIF Correction See all GeneRIFs (45)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • 9530095N19

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA polymerase binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables aryl hydrocarbon receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear glucocorticoid receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear receptor coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables nuclear retinoic acid receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear retinoid X receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear thyroid hormone receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coactivator activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to Thyroglobulin triiodothyronine IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in circadian rhythm IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peroxisome proliferator activated receptor signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of adipose tissue development NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of female receptivity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of glucocorticoid receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cellular response to insulin stimulus NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of lipid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to progesterone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
part_of RNA polymerase II transcription regulator complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
  
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription regulator complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nuclear receptor coactivator 2
Names
glucocorticoid receptor interacting protein 1
steroid receptor coactivator 2
transcriptional intermediary factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302702.1 → NP_001289631.1  nuclear receptor coactivator 2 isoform b

    See identical proteins and their annotated locations for NP_001289631.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (c) differs in the 5' UTR and lacks an in-frame exon compared to variant a. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AC091248, AK028964, AK035719, AK038781, AK042893, AK087443, BP761474, BU703942
    Consensus CDS
    CCDS35514.1
    UniProtKB/TrEMBL
    E9PV80, Q7TPU7
    Related
    ENSMUSP00000080413.5, ENSMUST00000081713.11
    Conserved Domains (9) summary
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam09606
    Location:1056 → 1334
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:28 → 91
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:1210 → 1267
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1002 → 1046
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636 → 709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268 → 378
    PAS_11; PAS domain
    pfam16279
    Location:731 → 816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463 → 587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  2. NM_008678.3 → NP_032704.2  nuclear receptor coactivator 2 isoform a

    See identical proteins and their annotated locations for NP_032704.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (a) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC091248, AK028964, AK035719, AK038781, AK042893, AK052117, AK087443, BP761474, BU703942
    Consensus CDS
    CCDS35515.1
    UniProtKB/Swiss-Prot
    E9QMH9, O09001, P97759, Q61026
    UniProtKB/TrEMBL
    Q7TPU7
    Related
    ENSMUSP00000006037.7, ENSMUST00000006037.13
    Conserved Domains (9) summary
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam09606
    Location:921 → 1424
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:28 → 91
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:1279 → 1336
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1071 → 1115
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636 → 709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268 → 378
    PAS_11; PAS domain
    pfam16279
    Location:731 → 816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463 → 587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    13209329..13444451 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162692.1 → XP_036018585.1  nuclear receptor coactivator 2 isoform X4

    UniProtKB/Swiss-Prot
    E9QMH9, O09001, P97759, Q61026
    UniProtKB/TrEMBL
    Q7TPU7
    Conserved Domains (9) summary
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam09606
    Location:921 → 1424
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:28 → 91
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:1279 → 1336
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1071 → 1115
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636 → 709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268 → 378
    PAS_11; PAS domain
    pfam16279
    Location:731 → 816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463 → 587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  2. XM_036162710.1 → XP_036018603.1  nuclear receptor coactivator 2 isoform X7

    UniProtKB/TrEMBL
    E9PV80, Q7TPU7
    Related
    ENSMUSP00000069509.7, ENSMUST00000068304.13
    Conserved Domains (9) summary
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam09606
    Location:1056 → 1334
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:28 → 91
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:1210 → 1267
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1002 → 1046
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636 → 709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268 → 378
    PAS_11; PAS domain
    pfam16279
    Location:731 → 816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463 → 587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  3. XM_030252088.1 → XP_030107948.1  nuclear receptor coactivator 2 isoform X3

    UniProtKB/TrEMBL
    Q7TPU7
    Conserved Domains (8) summary
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam08815
    Location:1076 → 1121
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam07469
    Location:1284 → 1340
    DUF1518; Domain of unknown function (DUF1518)
    pfam08832
    Location:636 → 709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268 → 378
    PAS_11; PAS domain
    pfam16279
    Location:731 → 816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463 → 587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    cd18950
    Location:28 → 91
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins

  4. XM_036162655.1 → XP_036018548.1  nuclear receptor coactivator 2 isoform X1

    UniProtKB/TrEMBL
    Q7TPU7
    Conserved Domains (9) summary
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam09606
    Location:1130 → 1408
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:28 → 91
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:1284 → 1341
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1076 → 1120
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636 → 709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268 → 378
    PAS_11; PAS domain
    pfam16279
    Location:731 → 816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463 → 587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  5. XM_030252095.2 → XP_030107955.1  nuclear receptor coactivator 2 isoform X7

    UniProtKB/TrEMBL
    E9PV80, Q7TPU7
    Conserved Domains (9) summary
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam09606
    Location:1056 → 1334
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:28 → 91
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:1210 → 1267
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1002 → 1046
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636 → 709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268 → 378
    PAS_11; PAS domain
    pfam16279
    Location:731 → 816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463 → 587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  6. XM_036162694.1 → XP_036018587.1  nuclear receptor coactivator 2 isoform X4

    UniProtKB/Swiss-Prot
    E9QMH9, O09001, P97759, Q61026
    UniProtKB/TrEMBL
    Q7TPU7
    Conserved Domains (9) summary
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam09606
    Location:921 → 1424
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:28 → 91
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:1279 → 1336
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1071 → 1115
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636 → 709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268 → 378
    PAS_11; PAS domain
    pfam16279
    Location:731 → 816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463 → 587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  7. XM_036162714.1 → XP_036018607.1  nuclear receptor coactivator 2 isoform X7

    UniProtKB/TrEMBL
    E9PV80, Q7TPU7
    Conserved Domains (9) summary
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam09606
    Location:1056 → 1334
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:28 → 91
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:1210 → 1267
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1002 → 1046
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636 → 709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268 → 378
    PAS_11; PAS domain
    pfam16279
    Location:731 → 816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463 → 587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  8. XM_036162698.1 → XP_036018591.1  nuclear receptor coactivator 2 isoform X4

    UniProtKB/Swiss-Prot
    E9QMH9, O09001, P97759, Q61026
    UniProtKB/TrEMBL
    Q7TPU7
    Conserved Domains (9) summary
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam09606
    Location:921 → 1424
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:28 → 91
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:1279 → 1336
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1071 → 1115
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636 → 709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268 → 378
    PAS_11; PAS domain
    pfam16279
    Location:731 → 816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463 → 587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  9. XM_036162703.1 → XP_036018596.1  nuclear receptor coactivator 2 isoform X6

    UniProtKB/TrEMBL
    Q7TPU7
    Conserved Domains (9) summary
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam09606
    Location:1056 → 1334
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:28 → 91
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:1210 → 1267
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1002 → 1046
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636 → 709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268 → 378
    PAS_11; PAS domain
    pfam16279
    Location:731 → 816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463 → 587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  10. XM_030252090.2 → XP_030107950.1  nuclear receptor coactivator 2 isoform X5

    UniProtKB/TrEMBL
    Q7TPU7
    Conserved Domains (10) summary
    TIGR01628
    Location:902 → 1021
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam08815
    Location:1007 → 1052
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam09606
    Location:1070 → 1360
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam07469
    Location:1215 → 1271
    DUF1518; Domain of unknown function (DUF1518)
    pfam08832
    Location:636 → 709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268 → 378
    PAS_11; PAS domain
    pfam16279
    Location:731 → 816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463 → 587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    cd18950
    Location:28 → 91
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins

  11. XM_030252087.2 → XP_030107947.1  nuclear receptor coactivator 2 isoform X2

    UniProtKB/TrEMBL
    Q7TPU7
    Conserved Domains (9) summary
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam08815
    Location:1071 → 1116
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam09606
    Location:921 → 1424
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam07469
    Location:1279 → 1335
    DUF1518; Domain of unknown function (DUF1518)
    pfam08832
    Location:636 → 709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268 → 378
    PAS_11; PAS domain
    pfam16279
    Location:731 → 816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463 → 587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    cd18950
    Location:28 → 91
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins

  12. XM_030252072.2 → XP_030107932.1  nuclear receptor coactivator 2 isoform X1

    UniProtKB/TrEMBL
    Q7TPU7
    Conserved Domains (9) summary
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam09606
    Location:1130 → 1408
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:28 → 91
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:1284 → 1341
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1076 → 1120
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636 → 709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268 → 378
    PAS_11; PAS domain
    pfam16279
    Location:731 → 816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463 → 587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  13. XM_030252093.2 → XP_030107953.1  nuclear receptor coactivator 2 isoform X6

    UniProtKB/TrEMBL
    Q7TPU7
    Conserved Domains (9) summary
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam09606
    Location:1056 → 1334
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:28 → 91
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:1210 → 1267
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1002 → 1046
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636 → 709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268 → 378
    PAS_11; PAS domain
    pfam16279
    Location:731 → 816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463 → 587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  14. XM_017319241.3 → XP_017174730.1  nuclear receptor coactivator 2 isoform X5

    UniProtKB/TrEMBL
    Q7TPU7
    Conserved Domains (10) summary
    TIGR01628
    Location:902 → 1021
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam08815
    Location:1007 → 1052
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam09606
    Location:1070 → 1360
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam07469
    Location:1215 → 1271
    DUF1518; Domain of unknown function (DUF1518)
    pfam08832
    Location:636 → 709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268 → 378
    PAS_11; PAS domain
    pfam16279
    Location:731 → 816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463 → 587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    cd18950
    Location:28 → 91
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins

  15. XM_017319229.3 → XP_017174718.1  nuclear receptor coactivator 2 isoform X1

    UniProtKB/TrEMBL
    Q7TPU7
    Conserved Domains (9) summary
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam09606
    Location:1130 → 1408
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:28 → 91
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:1284 → 1341
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1076 → 1120
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636 → 709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268 → 378
    PAS_11; PAS domain
    pfam16279
    Location:731 → 816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463 → 587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  16. XM_030252082.2 → XP_030107942.1  nuclear receptor coactivator 2 isoform X1

    UniProtKB/TrEMBL
    Q7TPU7
    Conserved Domains (9) summary
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam09606
    Location:1130 → 1408
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:28 → 91
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:1284 → 1341
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1076 → 1120
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636 → 709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268 → 378
    PAS_11; PAS domain
    pfam16279
    Location:731 → 816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463 → 587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  17. XM_030252068.2 → XP_030107928.1  nuclear receptor coactivator 2 isoform X1

    UniProtKB/TrEMBL
    Q7TPU7
    Conserved Domains (9) summary
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam09606
    Location:1130 → 1408
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:28 → 91
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:1284 → 1341
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1076 → 1120
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636 → 709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268 → 378
    PAS_11; PAS domain
    pfam16279
    Location:731 → 816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463 → 587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  18. XM_017319235.3 → XP_017174724.1  nuclear receptor coactivator 2 isoform X1

    UniProtKB/TrEMBL
    Q7TPU7
    Conserved Domains (9) summary
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam09606
    Location:1130 → 1408
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:28 → 91
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:1284 → 1341
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1076 → 1120
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636 → 709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268 → 378
    PAS_11; PAS domain
    pfam16279
    Location:731 → 816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463 → 587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  19. XM_036162665.1 → XP_036018558.1  nuclear receptor coactivator 2 isoform X1

    UniProtKB/TrEMBL
    Q7TPU7
    Conserved Domains (9) summary
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam09606
    Location:1130 → 1408
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:28 → 91
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:1284 → 1341
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1076 → 1120
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636 → 709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268 → 378
    PAS_11; PAS domain
    pfam16279
    Location:731 → 816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463 → 587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  20. XM_036162709.1 → XP_036018602.1  nuclear receptor coactivator 2 isoform X6

    UniProtKB/TrEMBL
    Q7TPU7
    Conserved Domains (9) summary
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam09606
    Location:1056 → 1334
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:28 → 91
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:1210 → 1267
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1002 → 1046
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636 → 709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268 → 378
    PAS_11; PAS domain
    pfam16279
    Location:731 → 816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463 → 587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  21. XM_017319233.3 → XP_017174722.1  nuclear receptor coactivator 2 isoform X1

    UniProtKB/TrEMBL
    Q7TPU7
    Conserved Domains (9) summary
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam09606
    Location:1130 → 1408
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:28 → 91
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:1284 → 1341
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1076 → 1120
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636 → 709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268 → 378
    PAS_11; PAS domain
    pfam16279
    Location:731 → 816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463 → 587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  22. XM_030252070.2 → XP_030107930.1  nuclear receptor coactivator 2 isoform X1

    UniProtKB/TrEMBL
    Q7TPU7
    Conserved Domains (9) summary
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam09606
    Location:1130 → 1408
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:28 → 91
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:1284 → 1341
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1076 → 1120
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636 → 709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268 → 378
    PAS_11; PAS domain
    pfam16279
    Location:731 → 816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463 → 587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  23. XM_017319232.3 → XP_017174721.1  nuclear receptor coactivator 2 isoform X1

    UniProtKB/TrEMBL
    Q7TPU7
    Conserved Domains (9) summary
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam09606
    Location:1130 → 1408
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:28 → 91
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:1284 → 1341
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1076 → 1120
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636 → 709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268 → 378
    PAS_11; PAS domain
    pfam16279
    Location:731 → 816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463 → 587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  24. XM_030252066.2 → XP_030107926.1  nuclear receptor coactivator 2 isoform X1

    UniProtKB/TrEMBL
    Q7TPU7
    Conserved Domains (9) summary
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam09606
    Location:1130 → 1408
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:28 → 91
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:1284 → 1341
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1076 → 1120
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636 → 709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268 → 378
    PAS_11; PAS domain
    pfam16279
    Location:731 → 816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463 → 587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  25. XM_036162671.1 → XP_036018564.1  nuclear receptor coactivator 2 isoform X1

    UniProtKB/TrEMBL
    Q7TPU7
    Conserved Domains (9) summary
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam09606
    Location:1130 → 1408
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:28 → 91
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:1284 → 1341
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1076 → 1120
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636 → 709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268 → 378
    PAS_11; PAS domain
    pfam16279
    Location:731 → 816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463 → 587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  26. XM_036162677.1 → XP_036018570.1  nuclear receptor coactivator 2 isoform X1

    UniProtKB/TrEMBL
    Q7TPU7
    Conserved Domains (9) summary
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam09606
    Location:1130 → 1408
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:28 → 91
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:1284 → 1341
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1076 → 1120
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636 → 709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268 → 378
    PAS_11; PAS domain
    pfam16279
    Location:731 → 816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463 → 587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  27. XM_030252075.2 → XP_030107935.1  nuclear receptor coactivator 2 isoform X1

    UniProtKB/TrEMBL
    Q7TPU7
    Conserved Domains (9) summary
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam09606
    Location:1130 → 1408
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:28 → 91
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:1284 → 1341
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1076 → 1120
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636 → 709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268 → 378
    PAS_11; PAS domain
    pfam16279
    Location:731 → 816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463 → 587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  28. XM_030252077.2 → XP_030107937.1  nuclear receptor coactivator 2 isoform X1

    UniProtKB/TrEMBL
    Q7TPU7
    Conserved Domains (9) summary
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam09606
    Location:1130 → 1408
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:28 → 91
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:1284 → 1341
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1076 → 1120
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636 → 709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268 → 378
    PAS_11; PAS domain
    pfam16279
    Location:731 → 816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463 → 587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  29. XM_030252083.2 → XP_030107943.1  nuclear receptor coactivator 2 isoform X1

    UniProtKB/TrEMBL
    Q7TPU7
    Conserved Domains (9) summary
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam09606
    Location:1130 → 1408
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:28 → 91
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:1284 → 1341
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1076 → 1120
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636 → 709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268 → 378
    PAS_11; PAS domain
    pfam16279
    Location:731 → 816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463 → 587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001077695.1: Suppressed sequence

    Description
    NM_001077695.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61026.3 GenPept UniProtKB/Swiss-Prot:Q61026

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