prp-6 Pre-mRNA-processing factor 6 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: prp-6
Gene description: Pre-mRNA-processing factor 6
Primary source: WormBase:WBGene00013343
Locus tag: CELE_Y59A8B.6
See related: AllianceGenome:WB:WBGene00013343
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to be involved in spliceosomal tri-snRNP complex assembly. Predicted to be located in nucleus. Predicted to be part of U4/U6 x U5 tri-snRNP complex and catalytic step 2 spliceosome. Human ortholog(s) of this gene implicated in retinitis pigmentosa 60. Orthologous to human PRPF6 (pre-mRNA processing factor 6). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: V

Exon count:: 13

Sequence:: Chromosome: V; NC_003283.11 (18022479..18042353)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y59A8C.b (e-PCR)
- UniSTS:324450

Y59A8C.a (e-PCR)
- UniSTS:323985

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Process	Evidence Code	Pubs
involved_in RNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info
involved_in spliceosomal tri-snRNP complex assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of U4/U6 x U5 tri-snRNP complex	IBA Inferred from Biological aspect of Ancestor more info
part_of catalytic step 2 spliceosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Pre-mRNA-processing factor 6

NP_507525.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

18022479..18042353

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_075124.8 → NP_507525.1 Pre-mRNA-processing factor 6 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_507525.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9GRZ2

Conserved Domains (4) summary

smart00386
Location:470 → 501

HAT; HAT (Half-A-TPR) repeats

sd00006
Location:702 → 730

TPR; TPR repeat [structural motif]

pfam06424
Location:22 → 182

PRP1_N; PRP1 splicing factor, N-terminal

pfam13414
Location:737 → 801

TPR_11; TPR repeat