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Pde4a phosphodiesterase 4A, cAMP specific [ Mus musculus (house mouse) ]

Gene ID: 18577, updated on 3-Apr-2024

Summary

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Official Symbol
Pde4aprovided by MGI
Official Full Name
phosphodiesterase 4A, cAMP specificprovided by MGI
Primary source
MGI:MGI:99558
See related
Ensembl:ENSMUSG00000032177 AllianceGenome:MGI:99558
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dpde2; D9Ertd60e
Summary
Enables 3',5'-cyclic-AMP phosphodiesterase activity. Acts upstream of or within cellular response to xenobiotic stimulus; regulation of signal transduction; and sensory perception of smell. Located in cytosol and membrane. Is expressed in several structures, including alimentary system; heart; integumental system; nervous system; and sensory organ. Orthologous to human PDE4A (phosphodiesterase 4A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 20.4), frontal lobe adult (RPKM 16.0) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Pde4a in Genome Data Viewer
Location:
9 A3; 9 7.73 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (21076998..21124544)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (21165700..21213248)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5054 Neighboring gene cell division cycle 37 Neighboring gene predicted gene, 36118 Neighboring gene predicted gene, 35977 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:20966019-20966202 Neighboring gene predicted gene, 39301 Neighboring gene STARR-positive B cell enhancer ABC_E1781 Neighboring gene STARR-seq mESC enhancer starr_23485 Neighboring gene predicted gene, 16754 Neighboring gene STARR-seq mESC enhancer starr_23486 Neighboring gene kelch-like ECH-associated protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E8278 Neighboring gene sphingosine-1-phosphate receptor 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. 6-Hydroxy-5,7-dimethoxy-flavone suppresses the neutrophil respiratory burst via selective PDE4 inhibition to ameliorate acute lung injury. Tsai YF, et al. Free Radic Biol Med, 2017 May. PMID 28263828
  2. Mice deficient in phosphodiesterase-4A display anxiogenic-like behavior. Hansen RT 3rd, et al. Psychopharmacology (Berl), 2014 Aug. PMID 24563185
  3. Physical mapping and promoter structure of the murine cAMP-specific phosphodiesterase pde4a gene. Olsen AE, et al. Mamm Genome, 2000 Jan. PMID 10602991
  4. Phosphodiesterase type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins. Tibbo AJ, et al. J Mol Cell Cardiol, 2022 Apr. PMID 34999055, Free PMC Article
  5. In cardiac myocytes, cAMP elevation triggers the down-regulation of transcripts and promoter activity for cyclic AMP phosphodiesterase-4A10 (PDE4A10). McCahill A, et al. Cell Signal, 2008 Nov. PMID 18721873

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Increased expression of phosphodiesterase 4 in activated hepatic stellate cells promotes cytoskeleton remodeling and cell migration.
    Title: Increased expression of phosphodiesterase 4 in activated hepatic stellate cells promotes cytoskeleton remodeling and cell migration.
  2. Phosphodiesterase type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins.
    Title: Phosphodiesterase type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins.
  3. In conclusion, our data demonstrated that UFM24 inhibits oxidative burst in human neutrophils through inhibition of PDE4 activity. UFM24 also exhibited significant protection against endotoxin-induced acute lung injury (ALI)in mice. UFM24 has potential as an anti-inflammatory agent for treating neutrophilic lung damage.
    Title: 6-Hydroxy-5,7-dimethoxy-flavone suppresses the neutrophil respiratory burst via selective PDE4 inhibition to ameliorate acute lung injury.
  4. PDE4 inhibition reduces neointima formation and inhibits VCAM-1 expression and histone methylation in an Epac-dependent manner.
    Title: PDE4 inhibition reduces neointima formation and inhibits VCAM-1 expression and histone methylation in an Epac-dependent manner.
  5. results suggest that PDE4A may be important in the regulation of emotional memory and anxiety-like behavior, but not emesis
    Title: Mice deficient in phosphodiesterase-4A display anxiogenic-like behavior.
  6. This study showed that long PDE4 isoforms provide a novel node for cross-talk between the cAMP and p38 MAPK signalling systems at the level of MK2.
    Title: Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation.
  7. Increased cAMP may remodel cAMP-mediated signalling events by not only increasing the expression of specific PDE4 cAMP phosphodiesterases but also by down-regulating specific isoforms, such as is shown here for PDE4A10 in cardiac myocytes.
    Title: In cardiac myocytes, cAMP elevation triggers the down-regulation of transcripts and promoter activity for cyclic AMP phosphodiesterase-4A10 (PDE4A10).
  8. a new mechanism in which phosphodiesterase PDE4A4/5 interacts with p75(NTR) to enhance cAMP degradation
    Title: p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables 3',5'-cyclic-AMP phosphodiesterase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables cAMP binding ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cAMP catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cAMP catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of protein kinase A signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sensory perception of smell IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in extrinsic component of membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
3',5'-cyclic-AMP phosphodiesterase 4A
Names
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
cAMP-specific phosphodiesterase 4A
cAMP-specific phosphodiesterase PDE4A
cyclic AMP specific phosphodiesterase PDE4A5A
dunce
NP_001297679.1
NP_001396218.1
NP_001396220.1
NP_001396221.1
NP_001396222.1
NP_001396223.1
NP_001396224.1
NP_001396225.1
NP_001396226.1
NP_062772.3
NP_899668.1
XP_030099987.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310750.2 → NP_001297679.1  3',5'-cyclic-AMP phosphodiesterase 4A isoform 6

    See identical proteins and their annotated locations for NP_001297679.1

    Status: VALIDATED

    Source sequence(s)
    AC163637
    Consensus CDS
    CCDS80964.1
    UniProtKB/TrEMBL
    Q3TUD0
    Related
    ENSMUSP00000111118.3, ENSMUST00000115458.9
    Conserved Domains (1) summary
    pfam00233
    Location:361 → 602
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  2. NM_001409289.1 → NP_001396218.1  3',5'-cyclic-AMP phosphodiesterase 4A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC163637

  3. NM_001409291.1 → NP_001396220.1  3',5'-cyclic-AMP phosphodiesterase 4A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC163637

  4. NM_001409292.1 → NP_001396221.1  3',5'-cyclic-AMP phosphodiesterase 4A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC163637

  5. NM_001409293.1 → NP_001396222.1  3',5'-cyclic-AMP phosphodiesterase 4A isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC163637

  6. NM_001409294.1 → NP_001396223.1  3',5'-cyclic-AMP phosphodiesterase 4A isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC163637

  7. NM_001409295.1 → NP_001396224.1  3',5'-cyclic-AMP phosphodiesterase 4A isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC163637

  8. NM_001409296.1 → NP_001396225.1  3',5'-cyclic-AMP phosphodiesterase 4A isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC163637

  9. NM_001409297.1 → NP_001396226.1  3',5'-cyclic-AMP phosphodiesterase 4A isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC163637

  10. NM_019798.6 → NP_062772.3  3',5'-cyclic-AMP phosphodiesterase 4A isoform 1

    See identical proteins and their annotated locations for NP_062772.3

    Status: VALIDATED

    Source sequence(s)
    AC163637
    Consensus CDS
    CCDS22896.1
    UniProtKB/TrEMBL
    C9K100
    Related
    ENSMUSP00000003395.10, ENSMUST00000003395.10
    Conserved Domains (1) summary
    pfam00233
    Location:184 → 425
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  11. NM_183408.4 → NP_899668.1  3',5'-cyclic-AMP phosphodiesterase 4A isoform 5

    See identical proteins and their annotated locations for NP_899668.1

    Status: VALIDATED

    Source sequence(s)
    AC163637
    Consensus CDS
    CCDS22895.1
    UniProtKB/Swiss-Prot
    O89084, Q8R078, Q9JHQ4, Q9QX48, Q9QX49, Q9QXI8
    UniProtKB/TrEMBL
    B2RTL2, Q3TUD0
    Related
    ENSMUSP00000037025.9, ENSMUST00000039413.15
    Conserved Domains (2) summary
    pfam00233
    Location:418 → 659
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:173 → 288
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    21076998..21124544
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244127.1 → XP_030099987.1  3',5'-cyclic-AMP phosphodiesterase 4A isoform X3

    UniProtKB/TrEMBL
    C9K100
    Conserved Domains (1) summary
    pfam00233
    Location:100 → 341
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

RNA

  1. XR_003947813.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O89084.2 GenPept UniProtKB/Swiss-Prot:O89084

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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