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Psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 [ Mus musculus (house mouse) ]

Gene ID: 19181, updated on 5-Mar-2024

Summary

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Official Symbol
Psmc2provided by MGI
Official Full Name
proteasome (prosome, macropain) 26S subunit, ATPase 2provided by MGI
Primary source
MGI:MGI:109555
See related
Ensembl:ENSMUSG00000028932 AllianceGenome:MGI:109555
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable TBP-class protein binding activity and proteasome-activating activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in P-body. Part of proteasome accessory complex. Is expressed in genitourinary system. Orthologous to human PSMC2 (proteasome 26S subunit, ATPase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 61.8), CNS E11.5 (RPKM 44.8) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 A3; 5 9.97 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (21990273..22008785)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (21785275..21803787)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12576 Neighboring gene predicted gene 15715 Neighboring gene peptidase (mitochondrial processing) beta Neighboring gene DnaJ heat shock protein family (Hsp40) member C2 Neighboring gene solute carrier family 26, member 5 Neighboring gene STARR-seq mESC enhancer starr_12580 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene reelin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Silencing Proteasome 26S Subunit ATPase 2 (PSMC2) Protects the Osteogenic Differentiation In Vitro and Osteogenesis In Vivo. Zhou B, et al. Calcif Tissue Int, 2021 Jul. PMID 33625534
  2. Uptake of pathogenic intracellular bacteria into human and murine macrophages downregulates the eukaryotic 26S protease complex ATPase gene. Schwan WR, et al. Infect Immun, 1997 Nov. PMID 9353061, Free PMC Article
  3. Defective mitosis due to a mutation in the gene for a fission yeast 26S protease subunit. Gordon C, et al. Nature, 1993 Nov 25. PMID 8247131
  4. A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14. Borodovsky A, et al. EMBO J, 2001 Sep 17. PMID 11566882, Free PMC Article
  5. Candidate gene isolation and comparative analysis of a commonly deleted segment of 7q22 implicated in myeloid malignancies. Kratz CP, et al. Genomics, 2001 Oct. PMID 11597142

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Silencing Proteasome 26S Subunit ATPase 2 (PSMC2) Protects the Osteogenic Differentiation In Vitro and Osteogenesis In Vivo.
    Title: Silencing Proteasome 26S Subunit ATPase 2 (PSMC2) Protects the Osteogenic Differentiation In Vitro and Osteogenesis In Vivo.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables TBP-class protein binding ISO
Inferred from Sequence Orthology
more info
  
enables general transcription initiation factor binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables proteasome-activating activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proteasome-activating activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in P-body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome accessory complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome regulatory particle, base subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
26S proteasome regulatory subunit 7
Names
26S protease regulatory subunit 7
26S proteasome AAA-ATPase subunit RPT1
proteasome 26S subunit ATPase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368661.1 → NP_001355590.1  26S proteasome regulatory subunit 7

    Status: VALIDATED

    Source sequence(s)
    AC125313
    Consensus CDS
    CCDS19108.1
    UniProtKB/Swiss-Prot
    O08531, P46471, Q3TGX5, Q9DBA1
    UniProtKB/TrEMBL
    Q3UIH5
    Conserved Domains (1) summary
    COG1222
    Location:23 → 430
    RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]

  2. NM_011188.4 → NP_035318.2  26S proteasome regulatory subunit 7

    Status: VALIDATED

    Source sequence(s)
    AC125313
    Consensus CDS
    CCDS19108.1
    UniProtKB/Swiss-Prot
    O08531, P46471, Q3TGX5, Q9DBA1
    UniProtKB/TrEMBL
    Q3UIH5
    Related
    ENSMUSP00000030769.7, ENSMUST00000030769.7
    Conserved Domains (1) summary
    COG1222
    Location:23 → 430
    RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    21990273..22008785
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46471.5 GenPept UniProtKB/Swiss-Prot:P46471

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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