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Sstr3 somatostatin receptor 3 [ Mus musculus (house mouse) ]

Gene ID: 20607, updated on 21-Apr-2024

Summary

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Official Symbol
Sstr3provided by MGI
Official Full Name
somatostatin receptor 3provided by MGI
Primary source
MGI:MGI:98329
See related
Ensembl:ENSMUSG00000044933 AllianceGenome:MGI:98329
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
sst3; Smstr3; Smstr-3
Summary
Enables signaling receptor binding activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Located in ciliary membrane and non-motile cilium. Is expressed in several structures, including adrenal gland; brain; gallbladder; genitourinary system; and gut. Orthologous to human SSTR3 (somatostatin receptor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 2.7), cortex adult (RPKM 2.1) and 9 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 E1; 15 37.55 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (78421214..78433565, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (78537014..78549365, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene interleukin 2 receptor, beta chain Neighboring gene C1q and tumor necrosis factor related protein 6 Neighboring gene STARR-positive B cell enhancer ABC_E4139 Neighboring gene STARR-seq mESC enhancer starr_39149 Neighboring gene L antigen family, member 3 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:78394443-78394712 Neighboring gene Rac family small GTPase 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:78402050-78402237 Neighboring gene STARR-positive B cell enhancer ABC_E11809

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Restricted expression of somatostatin receptor 3 to primary cilia in the pancreatic islets and adenohypophysis of mice. Iwanaga T, et al. Biomed Res, 2011 Feb. PMID 21383513
  2. Somatostatin receptor-3 mediated intracellular signaling and apoptosis is regulated by its cytoplasmic terminal. War SA, et al. Biochim Biophys Acta, 2011 Mar. PMID 21194548
  3. Cloning of a novel somatostatin receptor, SSTR3, coupled to adenylylcyclase. Yasuda K, et al. J Biol Chem, 1992 Oct 5. PMID 1328199
  4. Recruitment of β-Arrestin into Neuronal Cilia Modulates Somatostatin Receptor Subtype 3 Ciliary Localization. Green JA, et al. Mol Cell Biol, 2016 Jan 1. PMID 26503786, Free PMC Article
  5. Endosomal trafficking of the G protein-coupled receptor somatostatin receptor 3. Tower-Gilchrist C, et al. Biochem Biophys Res Commun, 2011 Oct 7. PMID 21925142, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Beta cell primary cilia mediate somatostatin responsiveness via SSTR3.
    Title: Beta cell primary cilia mediate somatostatin responsiveness via SSTR3.
  2. HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and C-terminal tails.
    Title: HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and C-terminal tails.
  3. Ubiquitin chains earmark GPCRs for BBSome-mediated removal from cilia.
    Title: Ubiquitin chains earmark GPCRs for BBSome-mediated removal from cilia.
  4. results implicate beta-arrestin in the modulation of Sstr3 ciliary localization and further suggest a role for beta-arrestin in the mediation of Sstr3 ciliary signaling.
    Title: Recruitment of β-Arrestin into Neuronal Cilia Modulates Somatostatin Receptor Subtype 3 Ciliary Localization.
  5. The expression and localization of the three receptors (SSTR3-SSTR5) in wild-type (WT), single-knockout (SSTR1 KO) and double-knockout SSTR1/SSTR2 (DKO) mice, are reported.
    Title: Expression and localization of somatostatin receptor types 3, 4 and 5 in the wild-type, SSTR1 and SSTR1/SSTR2 knockout mouse cochlea.
  6. Both Sstr3 (and SStr2) receptors are required for the anticonvulsant effects mediated by cortistatin-14.
    Title: Cortistatin-14 mediates its anticonvulsant effects via sst2 and sst3 but not ghrelin receptors.
  7. SSTR3 immunoreactivity increases in ApoD(-/-) mice in all major nuclei of hypothalamus, median eminence, and ependymal cells of third ventricle.
    Title: Immunohistochemical distribution of somatostatin and somatostatin receptor subtypes (SSTR1-5) in hypothalamus of ApoD knockout mice brain.
  8. Mchr1 and Sstr3 are expressed and colocalized within cilia in multiple mouse brain regions, and they form heteromers.
    Title: Heteromerization of ciliary G protein-coupled receptors in the mouse brain.
  9. this novel finding that Rab21 regulates SSTR3 trafficking suggests that Rab21 may play a role in trafficking of other GPCRs.
    Title: Endosomal trafficking of the G protein-coupled receptor somatostatin receptor 3.
  10. somatostatin receptor 3 expression was restricted to the plasma membrane of cilia in insulin- and growth hormone-secreting cells of the mouse, differing from previously reported immunohistochemical localization in cell bodies
    Title: Restricted expression of somatostatin receptor 3 to primary cilia in the pancreatic islets and adenohypophysis of mice.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables somatostatin receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in ciliary membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cilium ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in non-motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
somatostatin receptor type 3
Names
SS-3-R
SS3-R
SS3R
SSR-28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356961.1 → NP_001343890.1  somatostatin receptor type 3

    Status: VALIDATED

    Source sequence(s)
    AL590144
    Consensus CDS
    CCDS27617.1
    UniProtKB/Swiss-Prot
    P30935, Q0VB04, Q3UVV5
    Conserved Domains (2) summary
    cd14964
    Location:48 → 72
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:46 → 333
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. NM_001411768.1 → NP_001398697.1  somatostatin receptor type 3

    Status: VALIDATED

    Source sequence(s)
    AL590144
    UniProtKB/Swiss-Prot
    P30935, Q0VB04, Q3UVV5

  3. NM_009218.3 → NP_033244.2  somatostatin receptor type 3

    See identical proteins and their annotated locations for NP_033244.2

    Status: VALIDATED

    Source sequence(s)
    AL590144
    Consensus CDS
    CCDS27617.1
    UniProtKB/Swiss-Prot
    P30935, Q0VB04, Q3UVV5
    Related
    ENSMUSP00000058040.3, ENSMUST00000053239.4
    Conserved Domains (2) summary
    cd14964
    Location:48 → 72
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:46 → 333
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    78421214..78433565 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245531.2 → XP_011243833.1  somatostatin receptor type 3 isoform X1

    See identical proteins and their annotated locations for XP_011243833.1

    UniProtKB/Swiss-Prot
    P30935, Q0VB04, Q3UVV5
    Conserved Domains (2) summary
    cd14964
    Location:48 → 72
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:46 → 333
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30935.2 GenPept UniProtKB/Swiss-Prot:P30935

Gene LinkOut

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