AKT1 AKT serine/threonine kinase 1 [ Homo sapiens (human) ]

Gene ID: 207, updated on 13-Apr-2024

Summary

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Official Symbol: AKT1provided by HGNC
Official Full Name: AKT serine/threonine kinase 1provided by HGNC
Primary source: HGNC:HGNC:391
See related: Ensembl:ENSG00000142208 MIM:164730; AllianceGenome:HGNC:391
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AKT; PKB; RAC; PRKBA; PKB-ALPHA; RAC-ALPHA
Summary: This gene encodes one of the three members of the human AKT serine-threonine protein kinase family which are often referred to as protein kinase B alpha, beta, and gamma. These highly similar AKT proteins all have an N-terminal pleckstrin homology domain, a serine/threonine-specific kinase domain and a C-terminal regulatory domain. These proteins are phosphorylated by phosphoinositide 3-kinase (PI3K). AKT/PI3K forms a key component of many signalling pathways that involve the binding of membrane-bound ligands such as receptor tyrosine kinases, G-protein coupled receptors, and integrin-linked kinase. These AKT proteins therefore regulate a wide variety of cellular functions including cell proliferation, survival, metabolism, and angiogenesis in both normal and malignant cells. AKT proteins are recruited to the cell membrane by phosphatidylinositol 3,4,5-trisphosphate (PIP3) after phosphorylation of phosphatidylinositol 4,5-bisphosphate (PIP2) by PI3K. Subsequent phosphorylation of both threonine residue 308 and serine residue 473 is required for full activation of the AKT1 protein encoded by this gene. Phosphorylation of additional residues also occurs, for example, in response to insulin growth factor-1 and epidermal growth factor. Protein phosphatases act as negative regulators of AKT proteins by dephosphorylating AKT or PIP3. The PI3K/AKT signalling pathway is crucial for tumor cell survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating AKT1 which then phosphorylates and inactivates components of the apoptotic machinery. AKT proteins also participate in the mammalian target of rapamycin (mTOR) signalling pathway which controls the assembly of the eukaryotic translation initiation factor 4F (eIF4E) complex and this pathway, in addition to responding to extracellular signals from growth factors and cytokines, is disregulated in many cancers. Mutations in this gene are associated with multiple types of cancer and excessive tissue growth including Proteus syndrome and Cowden syndrome 6, and breast, colorectal, and ovarian cancers. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2020]
Expression: Ubiquitous expression in prostate (RPKM 26.1), lung (RPKM 25.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

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See AKT1 in Genome Data Viewer

Location:: 14q32.33

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (104769349..104795748, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (99012235..99038624, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (105235686..105262085, complement)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GSG2 promotes thyroid cancer via stabilizing AURKB and activating AKT pathway.
Title: GSG2 promotes thyroid cancer via stabilizing AURKB and activating AKT pathway.
SUMOylation of annexin A6 retards cell migration and tumor growth by suppressing RHOU/AKT1-involved EMT in hepatocellular carcinoma.
Title: SUMOylation of annexin A6 retards cell migration and tumor growth by suppressing RHOU/AKT1-involved EMT in hepatocellular carcinoma.
Differential prognostic values of the three AKT isoforms in acute myeloid leukemia.
Title: Differential prognostic values of the three AKT isoforms in acute myeloid leukemia.
HSPA4 regulated glioma progression via activation of AKT signaling pathway.
Title: HSPA4 regulated glioma progression via activation of AKT signaling pathway.
AKT1 interacts with DHX9 to Mitigate R Loop-Induced Replication Stress in Ovarian Cancer.
Title: AKT1 interacts with DHX9 to Mitigate R Loop-Induced Replication Stress in Ovarian Cancer.
Breast cancer malignancy is governed by regulation of the macroH2A2/TM4SF1 axis, the AKT/NF-kappaB pathway, and elevated MMP13 expression.
Title: Breast cancer malignancy is governed by regulation of the macroH2A2/TM4SF1 axis, the AKT/NF-κB pathway, and elevated MMP13 expression.
ABHD6 suppresses colorectal cancer progression via AKT signaling pathway.
Title: ABHD6 suppresses colorectal cancer progression via AKT signaling pathway.
All Three AKT Isoforms Can Upregulate Oxygen Metabolism and Lactate Production in Human Hepatocellular Carcinoma Cell Lines.
Title: All Three AKT Isoforms Can Upregulate Oxygen Metabolism and Lactate Production in Human Hepatocellular Carcinoma Cell Lines.
KLK10 promotes the progression of KRAS mutant colorectal cancer via PAR1-PDK1-AKT signaling pathway.
Title: KLK10 promotes the progression of KRAS mutant colorectal cancer via PAR1-PDK1-AKT signaling pathway.
STMN1 promotes cell malignancy and bortezomib resistance of multiple myeloma cell lines via PI3K/AKT signaling.
Title: STMN1 promotes cell malignancy and bortezomib resistance of multiple myeloma cell lines via PI3K/AKT signaling.

Submit: New GeneRIF Correction See all GeneRIFs (3102)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Colorectal cancer MedGen: C0346629 OMIM: 114500 GeneReviews: Lynch Syndrome	Compare labs
Cowden syndrome 6 MedGen: C3554519 OMIM: 615109 GeneReviews: Not available	Compare labs
Familial cancer of breast MedGen: C0346153 OMIM: 114480 GeneReviews: BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer	Compare labs
Neoplasm of ovary MedGen: C0919267 OMIM: 167000 GeneReviews: Not available	Compare labs
Proteus syndrome MedGen: C0085261 OMIM: 176920 GeneReviews: Proteus Syndrome	Compare labs

Copy number response

Description
Copy number response Haploinsufficency No evidence available (Last evaluated 2022-01-25) ClinGen Genome Curation Page Triplosensitivity No evidence available (Last evaluated 2022-01-25) ClinGen Genome Curation Page

EBI GWAS Catalog

Description
Discovery and refinement of loci associated with lipid levels. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of v-akt murine thymoma viral oncogene homolog 1 (AKT1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells	PubMed
Knockdown of v-akt murine thymoma viral oncogene homolog 1 (AKT1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 upregulates the expression of IL-6 and IL-8 via the p38 signaling pathway and the PI3K/Akt signaling pathway in astrocytes	PubMed
	env	HIV-1 gp120 activates AKT, ERK1/2, and p38 signaling in tonsil CD4+ T cells. Soluble CD4 inhibits AKT and ERK1/2 activation, but enhances phosphorylation of p38	PubMed
	env	Pre-treatment of endothelial cells with fibroblast growth factor 2 (FGF2) protects cells from HIV-1 gp120 angiotoxicity; this protection is regulated by crosstalk among the ERK, PI3K-AKT and PKC signaling pathways	PubMed
	env	Gp120-mediated activation of caspase-3 is significantly reduced in cells pretreated with PDGF-B. PDGF-mediated protection against gp120 involves the phosphoinositide (PI)3-kinase/Akt pathway	PubMed
	env	Treatment of human hepatic stellate cells with gp120 significantly increases secretion and gene expression of CCL2, metalloprotease-1 and interleukin-6. Gp120 also induces activation of Akt, NF-kappaB, and p38(MAPK)	PubMed
	env	Downregulation of the Wave2 signaling complex (Tiam-1, Abl, Rac, IRSp53, Wave2, and Arp3) with siRNA reduces HIV-1 Env-mediated cell-cell fusion and virus-cell fusion	PubMed
	env	Insulin-like growth factor-I (IGF-I) and erythropoietin treatment protect against HIV/gp120-mediated neuronal damage in culture and in vivo, in part, through cooperative activation of phosphatidylinositol 3-kinase/Akt/GSK-3beta signaling	PubMed
	env	HIV-1 gp120 induced cell death is inhibited by a CCR5-mediated neuroprotective pathway that involves protein kinase Akt/PKB as an essential component and can be triggered by the CCR5 agonists MIP-1beta and RANTES	PubMed
	env	CD45 modulates HIV-1 gp120-induced apoptosis by regulating Fas ligand induction and activation of the phosphoinositide 3-kinase/Akt pathway	PubMed
	env	Fractalkine (CX3CL1) protects hippocampal neurons from the neurotoxicity induced by the HIV-1 envelope protein gp120, and neuronal CX(3)CR1 receptors and Akt activation are responsible for the neuroprotective effects of fractalkine	PubMed
	env	HIV-1 gp120 downregulates expression of c-Myc, Max, and 14-3-3epsilon proteins, and decreases phosphorylation of ATP-dependent tyrosine kinases (Akt) at Ser-473 in human mesangial cells (HMC)	PubMed
Nef	nef	Recombinant HIV-1 Nef upregulates expression of antiapoptotic proteins BCL2, AKT1, and XIAP in THP-1 cells and primary blood macrophages	PubMed
	nef	HIV-1 Nef interacts with AKT1 and PI3K via its C and N terminal extremity, respectively	PubMed
	nef	Exogenous HIV-1 Nef enters peripheral blood lymphocytes and increases AKT1 phosphorylation	PubMed
	nef	HIV-1 Nef activates AKT1 in peripheral blood lymphocytes and is mediated by PI3K in a dose and time dependent manner	PubMed
	nef	HIV-1 Nef activates protein kinase B (AKT1/PKB) to inhibit autophagy in human mesenchymal stem cells	PubMed
	nef	HIV-1 Nef synergizes with KSHV oncoprotein K1 to activate PI3K/AKT/mTOR signaling pathway, and induces cell proliferation and microtubule formation in endothelial cells	PubMed
	nef	HIV-1 Nef induces phosphorylation of MEK1 at position serine 298, which depends on Pak and Rac activity	PubMed
	nef	HIV-1 Nef synergizes with IL-6 to activate the AKT pathway promoting angiogenesis and tumorigenesis in a chicken chorioallantoic membrane model and nude mice	PubMed
	nef	HIV-1 Nef synergizes with IL-6 to enhance vascular tube formation, cell proliferation, VEGF expression, and phosphorylated AKT activation in human umbilical vein endothelial cells	PubMed
	nef	Incubation of human macrophages with exogenous HIV-1 Nef protein induces phosphorylation of Akt and GSK-3ss, and promotes IL-10 release	PubMed
	nef	HIV-1 Nef decreases levels of AKT phosphorylation in insulin-stimulated adipocytes	PubMed
Tat	tat	HIV-1 Tat-induced activation of ICAM1 and VCAM1 is affected by AKT signalling in hCMEC/D3 cells	PubMed
	tat	HIV-1 Tat increases phosphorylation of ERK1/2, JNK1/2, p38, AKT1, MEK-1, and STAT-1alpha in Muller glia and brain microvascular pericytes	PubMed
	tat	The gene expression of v-akt murine thymoma viral oncogene homolog 1 is significantly upregulated in both clade B and clade C Tat treated SK-N-MC cells	PubMed
	tat	HIV-1 Tat and cocaine treatment activates PI3K and AKT in human pulmonary arterial smooth muscle cells	PubMed
	tat	Ginsenoside Rb1 and miltefosine synergistically abolish the cytoprotective CHME5 cells expressing HIV-1 Tat by inhibiting the AKT pathway	PubMed
	tat	Treatment with HIV-Tat and morphine activates extracellular signal-regulated kinase-1/2 (ERK1/2), upregulates p53 and p21 levels, and downregulates cyclin D1 and Akt levels in human fetal brain-derived neural precursor cells	PubMed
	tat	HIV-1 Tat induces phosphorylation of PI3K, AKT, PTEN, and GSK-3beta activating PI3K and AKT and inactivating PTEN and GSK-3beta in vIL-6 expressing cells	PubMed
	tat	PI3K/Akt, TRPC, and GSK3beta signaling pathways are all involved in PDGF-C mediated neuroprotection against HIV-1 Tat in human neuroblastoma cells	PubMed
	tat	Phosphatidylinositol 3-kinase/Akt signaling pathway is involved in HIV-1 Tat-induced NADPH oxidase stimulation and LTR transactivation	PubMed
	tat	HIV-1 Tat activates AKT kinase through activation of PI3 kinase, resulting in the protection of cells from apoptosis	PubMed
	tat	Lancemaside A1 inhibits the movement of Akt to the plasma membrane, a critical step for Akt activation, and Compound K inhibits Akt phosphorylation in Tat-expressing CHME5 cells	PubMed
	tat	PDGF-BB-mediated protection against HIV-1 Tat and morphine-induced neuron apoptosis involves Akt activation	PubMed
	tat	Epigallocatechin-3-gallate (EGCG)-mediated inhibition of HIV-1 Tat-induced LTR transactivation involves activation of Nrf2 and AMPK signaling pathways and inhibition of AKT signaling pathway in MAGI cells	PubMed
	tat	HIV-1 Tat inhibits autophagy in bystander macrophages/monocytic cells through Tat-mediated activation and phosphorylation of Src-Akt signaling	PubMed
	tat	A Coumarin derivative BPRHIV001 modulates Tat function through a reduction of the p300 protein level and a concordant reduction of phosphorylated Akt	PubMed
	tat	HIV-1 Tat in combination with IFN-gamma and TNF-alpha increases CXCL10 mRNA and protein in human astrocytes through the activation of the p38, Jnk, and Akt signaling pathways and their downstream transcription factors, NF-kappaB and STAT-1alpha	PubMed
	tat	HIV-1 Tat in combination with KSHV kaposin A activates the MEK/ERK, STAT3, and PI3K/Akt signals in NIH3T3 cells	PubMed
	tat	Pro-survival effects of intracellular HIV-1 Tat in a microglial cell line is attributed to activation of the PI-3-kinase (PI3K)/Akt pathway via decreasing expression of PTEN, a negative regulator of the PI-3-K pathway	PubMed
	tat	HIV-1 Tat downregulates CREB transcription factor expression in PC12 neuronal cells through activation of a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway	PubMed
	tat	HIV-1 Tat upregulates several anti-apoptotic genes, including AKT-1, AKT-2, BCL2, BCL-XL, and insulin-like growth factor I in vincristine-treated Kaposi's sarcoma cells	PubMed
Vpr	vpr	PI3K/Akt mediated activation of NFKB1 (NF-kappa-B) is involved in HIV-1 Vpr induced upregulation of IL6 in astrocytes	PubMed
	vpr	PI3K/Akt mediated activation of NFKB1 (NF-kappa-B) is involved in HIV-1 Vpr induced upregulation of CXCL8 (IL8) in astrocytes	PubMed
	vpr	HIV-1 Vpr-induced downregulation of sodium hydrogen exchanger, isoform 1 (NHE1), in Vpr(+) virus infected cells leads to acidification of cells, loss of ezrin, radixin and moesin (ERM) protein complex and decrease of AKT phosphorylation	PubMed
	vpr	HIV-1 Vpr inhibits Akt-induced cytoplasmic translocation of Foxo3a, a subtype of the forkhead transcription factors	PubMed
matrix	gag	HIV-1 MA natural variant S75X induces the phosphorylation of AKT (S473), ERK1/2 (T202/Y204), and ribosomal protein S6 (S235/236) in Epstein-Barr virus (EBV)-infected B-lymphocytes	PubMed
	gag	HIV-1 MA natural variant S75X-mediated proliferation of both Epstein-Barr virus (EBV)-infected primary and fully transformed B-lymphocytes requires AKT, ERK1/2, and STAT3 pathways	PubMed
	gag	HIV-1 p17 induces capillary-like structures in human endothelial cells by binding to CXCR1 and CXCR2, which requires activation of the Akt-dependent ERK signaling pathway	PubMed
	gag	HIV-1 p17 and its C-terminal truncated form of p17 (p17delta36) differentially regulate Akt phosphorylation by reducing and increasing phosphorylation levels of PTEN, respectively	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-AA041305 (e-PCR)
- UniSTS:79362

D11S2560 (e-PCR)
- UniSTS:37928

RH69160 (e-PCR)
- UniSTS:12879

RH47592 (e-PCR)
- UniSTS:42837

PMC15397P1 (e-PCR)
- UniSTS:271279

AKT1_41 (e-PCR)
- UniSTS:276984

RH101916 (e-PCR)
- UniSTS:96251

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 14-3-3 protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ATP binding	IC Inferred by Curator more info	PubMed
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables nitric-oxide synthase regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphatidylinositol-3,4,5-trisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-3,4-bisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables potassium channel activator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	EXP Inferred from Experiment more info	PubMed
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine/threonine kinase activity	NAS Non-traceable Author Statement more info	PubMed
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info	PubMed
enables protein serine/threonine kinase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine/threonine kinase inhibitor activity	TAS Traceable Author Statement more info	PubMed
enables protein serine/threonine/tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in T cell costimulation	TAS Traceable Author Statement more info
involved_in TOR signaling	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within activation-induced cell death of T cells	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anoikis	NAS Non-traceable Author Statement more info	PubMed
involved_in apoptotic mitochondrial changes	IEA Inferred from Electronic Annotation more info
involved_in behavioral response to pain	IEA Inferred from Electronic Annotation more info
involved_in canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	TAS Traceable Author Statement more info	PubMed
involved_in cell migration involved in sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell population proliferation	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to cadmium ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to decreased oxygen levels	IEA Inferred from Electronic Annotation more info
involved_in cellular response to epidermal growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to insulin stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to insulin stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to insulin stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to nerve growth factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to oxidised low-density lipoprotein particle stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to prostaglandin E stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to reactive oxygen species	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info
involved_in cellular response to vascular endothelial growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cytokine-mediated signaling pathway	TAS Traceable Author Statement more info
involved_in epidermal growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in establishment of protein localization to mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in excitatory postsynaptic potential	NAS Non-traceable Author Statement more info	PubMed
involved_in execution phase of apoptosis	IEA Inferred from Electronic Annotation more info
involved_in fibroblast migration	NAS Non-traceable Author Statement more info	PubMed
involved_in gene expression	IEA Inferred from Electronic Annotation more info
involved_in glucose homeostasis	IEA Inferred from Electronic Annotation more info
involved_in glucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycogen biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in insulin-like growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in interleukin-18-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in labyrinthine layer blood vessel development	IEA Inferred from Electronic Annotation more info
involved_in lipopolysaccharide-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in maintenance of protein location in mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mammalian oogenesis stage	IEA Inferred from Electronic Annotation more info
involved_in mammary gland epithelial cell differentiation	TAS Traceable Author Statement more info	PubMed
involved_in maternal placenta development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Notch signaling pathway	TAS Traceable Author Statement more info
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cGAS/STING signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cilium assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of fatty acid beta-oxidation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of leukocyte cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of long-chain fatty acid import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of lymphocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of macroautophagy	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of protein binding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein localization to lysosome	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein serine/threonine kinase activity	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of proteolysis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of release of cytochrome c from mitochondria	ISS Inferred from Sequence or Structural Similarity more info
involved_in nitric oxide biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in non-canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in osteoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-serine phosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in peptidyl-threonine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peripheral nervous system myelin maintenance	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	TAS Traceable Author Statement more info
involved_in phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of I-kappaB phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of TORC1 signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of blood vessel endothelial cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endodeoxyribonuclease activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fibroblast migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of glucose import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glucose metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glycogen biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glycogen biosynthetic process	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of lipid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of lipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nitric oxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nitric-oxide synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of organ growth	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein localization to cell surface	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein localization to endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein localization to nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of smooth muscle cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in protein autophosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell migration	TAS Traceable Author Statement more info	PubMed
involved_in regulation of glycogen biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mRNA stability	TAS Traceable Author Statement more info
involved_in regulation of myelination	IEA Inferred from Electronic Annotation more info
involved_in regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of postsynapse organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of signal transduction by p53 class mediator	TAS Traceable Author Statement more info
involved_in regulation of tRNA methylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in regulation of type B pancreatic cell development	TAS Traceable Author Statement more info
involved_in response to UV-A	IDA Inferred from Direct Assay more info	PubMed
involved_in response to fluid shear stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to food	IEA Inferred from Electronic Annotation more info
involved_in response to growth factor	IDA Inferred from Direct Assay more info	PubMed
involved_in response to growth hormone	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to heat	IEA Inferred from Electronic Annotation more info
involved_in response to insulin-like growth factor stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to oxidative stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in sphingosine-1-phosphate receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in striated muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in virus-mediated perturbation of host defense response	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell cortex	NAS Non-traceable Author Statement more info	PubMed
located_in cell-cell junction	IEA Inferred from Electronic Annotation more info
located_in ciliary basal body	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	NAS Non-traceable Author Statement more info	PubMed
is_active_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	TAS Traceable Author Statement more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
located_in postsynapse	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	IEA Inferred from Electronic Annotation more info
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: RAC-alpha serine/threonine-protein kinase

Names: AKT1m; PKB alpha; RAC-PK-alpha; protein kinase B alpha; proto-oncogene c-Akt; rac protein kinase alpha; serine-threonine protein kinase; v-akt murine thymoma viral oncogene homolog 1; v-akt murine thymoma viral oncogene-like protein 1

NP_001014431.1

EC 2.7.11.1

NP_001014432.1

EC 2.7.11.1

NP_001369359.1

EC 2.7.11.1

NP_001369360.1

EC 2.7.11.1

NP_001369361.1

EC 2.7.11.1

NP_001369362.1

EC 2.7.11.1

NP_005154.2

EC 2.7.11.1

XP_047287025.1

EC 2.7.11.1

XP_047287026.1

EC 2.7.11.1

XP_047287027.1

EC 2.7.11.1

XP_047287028.1

EC 2.7.11.1

XP_047287029.1

EC 2.7.11.1

XP_047287030.1

EC 2.7.11.1

XP_047287031.1

EC 2.7.11.1

XP_054231528.1

EC 2.7.11.1

XP_054231529.1

EC 2.7.11.1

XP_054231530.1

EC 2.7.11.1

XP_054231531.1

EC 2.7.11.1

XP_054231532.1

EC 2.7.11.1

XP_054231533.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012188.1 RefSeqGene

Range

5001..31396

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_721

mRNA and Protein(s)

NM_001014431.2 → NP_001014431.1 RAC-alpha serine/threonine-protein kinase

See identical proteins and their annotated locations for NP_001014431.1

Status: REVIEWED

Source sequence(s)

AL583722, AL590327

Consensus CDS

CCDS9994.1

UniProtKB/Swiss-Prot

B2RAM5, B7Z5R1, P31749, Q9BWB6

UniProtKB/TrEMBL

B0LPE5, B3KVH4

Related

ENSP00000384293.2, ENST00000407796.7

Conserved Domains (2) summary

cd01241
Location:4 → 111

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

cd05594
Location:124 → 479

STKc_PKB_alpha; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1)
NM_001014432.2 → NP_001014432.1 RAC-alpha serine/threonine-protein kinase

See identical proteins and their annotated locations for NP_001014432.1

Status: REVIEWED

Source sequence(s)

AL583722, AL590327

Consensus CDS

CCDS9994.1

UniProtKB/Swiss-Prot

B2RAM5, B7Z5R1, P31749, Q9BWB6

UniProtKB/TrEMBL

B0LPE5, B3KVH4

Related

ENSP00000270202.4, ENST00000349310.7

Conserved Domains (2) summary

cd01241
Location:4 → 111

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

cd05594
Location:124 → 479

STKc_PKB_alpha; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1)
NM_001382430.1 → NP_001369359.1 RAC-alpha serine/threonine-protein kinase

Status: REVIEWED

Source sequence(s)

AL583722, AL590327

Consensus CDS

CCDS9994.1

UniProtKB/Swiss-Prot

B2RAM5, B7Z5R1, P31749, Q9BWB6

UniProtKB/TrEMBL

B0LPE5, B3KVH4

Related

ENSP00000497822.1, ENST00000649815.2

Conserved Domains (2) summary

cd01241
Location:4 → 111

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

cd05594
Location:124 → 479

STKc_PKB_alpha; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1)
NM_001382431.1 → NP_001369360.1 RAC-alpha serine/threonine-protein kinase

Status: REVIEWED

Source sequence(s)

AL583722, AL590327

Consensus CDS

CCDS9994.1

UniProtKB/Swiss-Prot

B2RAM5, B7Z5R1, P31749, Q9BWB6

UniProtKB/TrEMBL

B0LPE5, B3KVH4

Conserved Domains (2) summary

cd01241
Location:4 → 111

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

cd05594
Location:124 → 479

STKc_PKB_alpha; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1)
NM_001382432.1 → NP_001369361.1 RAC-alpha serine/threonine-protein kinase

Status: REVIEWED

Source sequence(s)

AL583722, AL590327

Consensus CDS

CCDS9994.1

UniProtKB/Swiss-Prot

B2RAM5, B7Z5R1, P31749, Q9BWB6

UniProtKB/TrEMBL

B0LPE5, B3KVH4

Conserved Domains (2) summary

cd01241
Location:4 → 111

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

cd05594
Location:124 → 479

STKc_PKB_alpha; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1)
NM_001382433.1 → NP_001369362.1 RAC-alpha serine/threonine-protein kinase

Status: REVIEWED

Source sequence(s)

AL583722, AL590327

Consensus CDS

CCDS9994.1

UniProtKB/Swiss-Prot

B2RAM5, B7Z5R1, P31749, Q9BWB6

UniProtKB/TrEMBL

B0LPE5, B3KVH4

Conserved Domains (2) summary

cd01241
Location:4 → 111

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

cd05594
Location:124 → 479

STKc_PKB_alpha; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1)
NM_005163.2 → NP_005154.2 RAC-alpha serine/threonine-protein kinase

See identical proteins and their annotated locations for NP_005154.2

Status: REVIEWED

Source sequence(s)

AK122894, BC000479

Consensus CDS

CCDS9994.1

UniProtKB/Swiss-Prot

B2RAM5, B7Z5R1, P31749, Q9BWB6

UniProtKB/TrEMBL

B0LPE5, B3KVH4

Related

ENSP00000450688.1, ENST00000555528.5

Conserved Domains (2) summary

cd01241
Location:4 → 111

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

cd05594
Location:124 → 479

STKc_PKB_alpha; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000014.9 Reference GRCh38.p14 Primary Assembly

Range

104769349..104795748 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047431075.1 → XP_047287031.1 RAC-alpha serine/threonine-protein kinase isoform X1

UniProtKB/Swiss-Prot

B2RAM5, B7Z5R1, P31749, Q9BWB6

UniProtKB/TrEMBL

B0LPE5
XM_047431074.1 → XP_047287030.1 RAC-alpha serine/threonine-protein kinase isoform X1

UniProtKB/Swiss-Prot

B2RAM5, B7Z5R1, P31749, Q9BWB6

UniProtKB/TrEMBL

B0LPE5
XM_047431069.1 → XP_047287025.1 RAC-alpha serine/threonine-protein kinase isoform X1

UniProtKB/Swiss-Prot

B2RAM5, B7Z5R1, P31749, Q9BWB6

UniProtKB/TrEMBL

B0LPE5
XM_047431071.1 → XP_047287027.1 RAC-alpha serine/threonine-protein kinase isoform X1

UniProtKB/Swiss-Prot

B2RAM5, B7Z5R1, P31749, Q9BWB6

UniProtKB/TrEMBL

B0LPE5

Related

ENSP00000451166.1, ENST00000554848.5
XM_047431072.1 → XP_047287028.1 RAC-alpha serine/threonine-protein kinase isoform X1

UniProtKB/Swiss-Prot

B2RAM5, B7Z5R1, P31749, Q9BWB6

UniProtKB/TrEMBL

B0LPE5
XM_047431070.1 → XP_047287026.1 RAC-alpha serine/threonine-protein kinase isoform X1

UniProtKB/Swiss-Prot

B2RAM5, B7Z5R1, P31749, Q9BWB6

UniProtKB/TrEMBL

B0LPE5
XM_047431073.1 → XP_047287029.1 RAC-alpha serine/threonine-protein kinase isoform X1

UniProtKB/Swiss-Prot

B2RAM5, B7Z5R1, P31749, Q9BWB6

UniProtKB/TrEMBL

B0LPE5

Related

ENSP00000451828.1, ENST00000554581.5

Alternate T2T-CHM13v2.0

Genomic

NC_060938.1 Alternate T2T-CHM13v2.0

Range

99012235..99038624 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054375558.1 → XP_054231533.1 RAC-alpha serine/threonine-protein kinase isoform X1

UniProtKB/Swiss-Prot

B2RAM5, B7Z5R1, P31749, Q9BWB6

UniProtKB/TrEMBL

B0LPE5
XM_054375553.1 → XP_054231528.1 RAC-alpha serine/threonine-protein kinase isoform X1

UniProtKB/Swiss-Prot

B2RAM5, B7Z5R1, P31749, Q9BWB6

UniProtKB/TrEMBL

B0LPE5
XM_054375556.1 → XP_054231531.1 RAC-alpha serine/threonine-protein kinase isoform X1

UniProtKB/Swiss-Prot

B2RAM5, B7Z5R1, P31749, Q9BWB6

UniProtKB/TrEMBL

B0LPE5
XM_054375555.1 → XP_054231530.1 RAC-alpha serine/threonine-protein kinase isoform X1

UniProtKB/Swiss-Prot

B2RAM5, B7Z5R1, P31749, Q9BWB6

UniProtKB/TrEMBL

B0LPE5
XM_054375554.1 → XP_054231529.1 RAC-alpha serine/threonine-protein kinase isoform X1

UniProtKB/Swiss-Prot

B2RAM5, B7Z5R1, P31749, Q9BWB6

UniProtKB/TrEMBL

B0LPE5
XM_054375557.1 → XP_054231532.1 RAC-alpha serine/threonine-protein kinase isoform X1

UniProtKB/Swiss-Prot

B2RAM5, B7Z5R1, P31749, Q9BWB6

UniProtKB/TrEMBL

B0LPE5