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FN1 fibronectin 1 [ Homo sapiens (human) ]

Gene ID: 2335, updated on 16-Apr-2024

Summary

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Official Symbol
FN1provided by HGNC
Official Full Name
fibronectin 1provided by HGNC
Primary source
HGNC:HGNC:3778
See related
Ensembl:ENSG00000115414 MIM:135600; AllianceGenome:HGNC:3778
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FN; CIG; FNZ; MSF; ED-B; FINC; GFND; LETS; GFND2; SMDCF
Summary
This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined. [provided by RefSeq, Jan 2016]
Expression
Biased expression in placenta (RPKM 1097.5), liver (RPKM 415.5) and 7 other tissues See more
Orthologs
mouse all
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Genomic context

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See FN1 in Genome Data Viewer
Location:
2q35
Exon count:
47
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (215360865..215436068, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (215845895..215921094, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (216225588..216300791, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC124907975 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:216176486-216177136 Neighboring gene 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:216240057-216241256 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:216255920-216257119 Neighboring gene Sharpr-MPRA regulatory region 14446 Neighboring gene Sharpr-MPRA regulatory region 10603 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:216288045-216289244 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:216298103-216299302 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12299 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12300 Neighboring gene uncharacterized LOC102724849 Neighboring gene FN1 divergent transcript Neighboring gene Sharpr-MPRA regulatory region 5619 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:216392847-216394046 Neighboring gene uncharacterized LOC102724861 Neighboring gene Sharpr-MPRA regulatory region 4559 Neighboring gene NANOG hESC enhancer GRCh37_chr2:216491401-216491902 Neighboring gene long intergenic non-protein coding RNA 607

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Integrated analysis of circulating and tissue proteomes reveals that fibronectin 1 is a potential biomarker in papillary thyroid cancer. Ye G, et al. BMC Cancer, 2023 May 8. PMID 37158852, Free PMC Article
  2. High FN1 expression is associated with poor survival in esophageal squamous cell carcinoma. Ma J, et al. Medicine (Baltimore), 2023 Apr 7. PMID 37026938, Free PMC Article
  3. RNA-Seq Analysis of Extradomain A and Extradomain B Fibronectin as Extracellular Matrix Markers for Cancer. Hall RC, et al. Cells, 2023 Feb 21. PMID 36899821, Free PMC Article
  4. Characterization of fibronectin properties by integrated micro-fluidic experiments and fluid-structure interaction simulations. Ke R, et al. J Biomech, 2023 Mar. PMID 36867952
  5. A high-impact FN1 variant correlates with fibronectin-mediated glomerulopathy via decreased binding to collagen type IV. Qiu J, et al. Pathology, 2023 Jun. PMID 36774238

See all (842) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Superficial acral calcified chondroid mesenchymal neoplasm harboring an FN1::FGFR2 fusion and review of the literature.
    Title: Superficial acral calcified chondroid mesenchymal neoplasm harboring an FN1::FGFR2 fusion and review of the literature.
  2. Myocardin regulates fibronectin expression and secretion from human pleural mesothelial cells.
    Title: Myocardin regulates fibronectin expression and secretion from human pleural mesothelial cells.
  3. LncRNA ADAMTS9-AS2 regulates periodontal ligament cell migration under mechanical compression via ADAMTS9/fibronectin.
    Title: LncRNA ADAMTS9-AS2 regulates periodontal ligament cell migration under mechanical compression via ADAMTS9/fibronectin.
  4. Single-cell RNA sequencing reveals association of aberrant placental trophoblasts and FN1 reduction in late-onset fetal growth restriction.
    Title: Single-cell RNA sequencing reveals association of aberrant placental trophoblasts and FN1 reduction in late-onset fetal growth restriction.
  5. Circular RNA hsa_circ_0050386 suppresses non-small cell lung cancer progression via regulating the SRSF3/FN1 axis.
    Title: Circular RNA hsa_circ_0050386 suppresses non-small cell lung cancer progression via regulating the SRSF3/FN1 axis.
  6. Fibronectin sensitizes activation of contractility, YAP, and NF-kappaB in nucleus pulposus cells.
    Title: Fibronectin sensitizes activation of contractility, YAP, and NF-κB in nucleus pulposus cells.
  7. FN1 and cancer-associated fibroblasts markers influence immune microenvironment in clear cell renal cell carcinoma.
    Title: FN1 and cancer-associated fibroblasts markers influence immune microenvironment in clear cell renal cell carcinoma.
  8. FN1 and TGFBI are key biomarkers of macrophage immune injury in diabetic kidney disease.
    Title: FN1 and TGFBI are key biomarkers of macrophage immune injury in diabetic kidney disease.
  9. Anti-Liver Fibrosis Role of miRNA-96-5p via Targeting FN1 and Inhibiting ECM-Receptor Interaction Pathway.
    Title: Anti-Liver Fibrosis Role of miRNA-96-5p via Targeting FN1 and Inhibiting ECM-Receptor Interaction Pathway.
  10. Adhesion of human pathogenic bacteria to endothelial cells is facilitated by fibronectin interaction.
    Title: Adhesion of human pathogenic bacteria to endothelial cells is facilitated by fibronectin interaction.
Submit: New GeneRIF Correction See all GeneRIFs (546)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex.
EBI GWAS Catalog
Discovery and refinement of loci associated with lipid levels.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 induces phosphorylation of fibronectin and enhances a physical association between fibronectin and Robo4 in human lymphatic endothelial cells PubMed
env Fibronectin, which is present in submandibular saliva, binds to HIV-1 gp120/160 and enhances the interaction of C1q with gp120/160 PubMed
env HIV-1 gp120 binds to fibronectin (FN) present on the surface of platelets; the specificity of this binding is confirmed by the inhibition obtained by pretreating platelets with anti-FN antibodies PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 and gp120 specifically recognize the C-terminal heparin-binding domain of fibronectin (Fn) and this binding inhibits the interaction of gp160/gp120 with soluble CD4 PubMed
Envelope transmembrane glycoprotein gp41 env Fibronectin (FN) binds to HIV-1 glycoproteins, including gp41 and gp120; preincubation with antibodies against FN abolishes this binding PubMed
Nef nef Exogenous HIV-1 Nef upregulates fibronectin (FN) expression in MT4 and H9 T-cell lines PubMed
Tat tat HIV-1 Tat competes with fibronectin for binding to integrins PubMed
tat Fibronectin modulates the effects of HIV-1 Tat on endothelial cells and murine Kaposi's sarcoma-like cells PubMed
tat HIV-1 Tat upregulates fibronectin expression in salivary gland cell lines, thymic epithelial cells, and glioblastoma cells PubMed
retropepsin gag-pol The cell-associated protein fibronectin (A-chain) is specifically cleaved in vitro by HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp686H0342, DKFZp686I1370, DKFZp686F10164, DKFZp686O13149

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables collagen binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables extracellular matrix structural constituent HDA PubMed 
enables extracellular matrix structural constituent ISS
Inferred from Sequence or Structural Similarity
more info
  
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
enables heparin binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables integrin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables integrin binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables integrin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables peptidase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables protease binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables proteoglycan binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proteoglycan binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables signaling receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in acute-phase response IEA
Inferred from Electronic Annotation
more info
  
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in biological process involved in interaction with symbiont IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in calcium-independent cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-substrate junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endodermal cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heart development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in integrin activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in integrin-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of monocyte activation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transforming growth factor beta production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neural crest cell migration involved in autonomic nervous system development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptide cross-linking IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of axon extension IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of fibroblast proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of substrate-dependent cell migration, cell attachment to substrate IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to wounding NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in substrate adhesion-dependent cell spreading IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in wound healing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in basement membrane IEA
Inferred from Electronic Annotation
more info
  
located_in blood microparticle HDA PubMed 
colocalizes_with collagen-containing extracellular matrix HDA PubMed 
located_in collagen-containing extracellular matrix HDA PubMed 
located_in collagen-containing extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with collagen-containing extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in extracellular exosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region HDA PubMed 
located_in extracellular region NAS
Non-traceable Author Statement
more info
 PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in extracellular space HDA PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
part_of fibrinogen complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of fibrinogen complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in platelet alpha granule lumen TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
fibronectin
Names
cold-insoluble globulin
epididymis secretory sperm binding protein
lnc-ABCA12-8
migration-stimulating factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012196.2 RefSeqGene

    Range
    5000..80203
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001306129.2 → NP_001293058.2  fibronectin isoform 8 precursor

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    Consensus CDS
    CCDS77526.1
    UniProtKB/TrEMBL
    B7ZLE5
    Related
    ENSP00000323534.6, ENST00000323926.10
    Conserved Domains (6) summary
    smart00059
    Location:353 → 401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186 → 230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:2354 → 2393
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:1995 → 2075
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231 → 270
    fn1; Fibronectin type I domain
    pfam00041
    Location:1540 → 1621
    fn3; Fibronectin type III domain

  2. NM_001306130.2 → NP_001293059.2  fibronectin isoform 9 precursor

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    Consensus CDS
    CCDS77525.1
    UniProtKB/TrEMBL
    A0A384MR03
    Related
    ENSP00000399538.2, ENST00000432072.6
    Conserved Domains (6) summary
    smart00059
    Location:353 → 401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186 → 230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:2175 → 2214
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:1905 → 1985
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231 → 270
    fn1; Fibronectin type I domain
    pfam00041
    Location:1540 → 1621
    fn3; Fibronectin type III domain

  3. NM_001306131.2 → NP_001293060.2  fibronectin isoform 10 precursor

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    Consensus CDS
    CCDS77523.1
    UniProtKB/TrEMBL
    B7ZLE5
    Related
    ENSP00000415018.1, ENST00000443816.5
    Conserved Domains (6) summary
    smart00059
    Location:353 → 401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186 → 230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:2173 → 2212
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:1814 → 1894
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231 → 270
    fn1; Fibronectin type I domain
    pfam00041
    Location:1449 → 1530
    fn3; Fibronectin type III domain

  4. NM_001306132.2 → NP_001293061.2  fibronectin isoform 11 precursor

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    Consensus CDS
    CCDS77522.1
    UniProtKB/TrEMBL
    B7ZLE5
    Related
    ENSP00000394423.1, ENST00000421182.5
    Conserved Domains (6) summary
    smart00059
    Location:353 → 401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186 → 230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:2148 → 2187
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:1814 → 1894
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231 → 270
    fn1; Fibronectin type I domain
    pfam00041
    Location:1449 → 1530
    fn3; Fibronectin type III domain

  5. NM_001365517.2 → NP_001352446.1  fibronectin isoform 12 precursor

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    UniProtKB/TrEMBL
    B7ZLE5
    Conserved Domains (5) summary
    smart00059
    Location:353 → 401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186 → 230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:2295 → 2334
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00039
    Location:231 → 270
    fn1; Fibronectin type I domain
    pfam00041
    Location:1540 → 1619
    fn3; Fibronectin type III domain

  6. NM_001365518.2 → NP_001352447.1  fibronectin isoform 13 precursor

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    Consensus CDS
    CCDS92940.1
    UniProtKB/TrEMBL
    B7ZLE5
    Related
    ENSP00000352696.1, ENST00000359671.5
    Conserved Domains (5) summary
    smart00059
    Location:353 → 401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186 → 230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:2294 → 2333
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00039
    Location:231 → 270
    fn1; Fibronectin type I domain
    pfam00041
    Location:1449 → 1528
    fn3; Fibronectin type III domain

  7. NM_001365519.2 → NP_001352448.1  fibronectin isoform 14 precursor

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    UniProtKB/TrEMBL
    B7ZLE5
    Conserved Domains (5) summary
    smart00059
    Location:353 → 401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186 → 230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:2270 → 2309
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00039
    Location:231 → 270
    fn1; Fibronectin type I domain
    pfam00041
    Location:1540 → 1619
    fn3; Fibronectin type III domain

  8. NM_001365520.2 → NP_001352449.1  fibronectin isoform 15 precursor

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    UniProtKB/TrEMBL
    B7ZLE5
    Conserved Domains (5) summary
    smart00059
    Location:353 → 401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186 → 230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:2269 → 2308
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00039
    Location:231 → 270
    fn1; Fibronectin type I domain
    pfam00041
    Location:1449 → 1528
    fn3; Fibronectin type III domain

  9. NM_001365521.2 → NP_001352450.1  fibronectin isoform 16 precursor

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    UniProtKB/TrEMBL
    B7ZLE5
    Conserved Domains (5) summary
    smart00059
    Location:353 → 401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186 → 230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:2264 → 2303
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00039
    Location:231 → 270
    fn1; Fibronectin type I domain
    pfam00041
    Location:1540 → 1619
    fn3; Fibronectin type III domain

  10. NM_001365522.2 → NP_001352451.1  fibronectin isoform 17 precursor

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    UniProtKB/TrEMBL
    B7ZLE5
    Conserved Domains (5) summary
    smart00059
    Location:353 → 401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186 → 230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:2239 → 2278
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00039
    Location:231 → 270
    fn1; Fibronectin type I domain
    pfam00041
    Location:1540 → 1619
    fn3; Fibronectin type III domain

  11. NM_001365523.2 → NP_001352452.1  fibronectin isoform 18 precursor

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    UniProtKB/TrEMBL
    B7ZLE5
    Conserved Domains (5) summary
    smart00059
    Location:353 → 401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186 → 230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:2179 → 2218
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00039
    Location:231 → 270
    fn1; Fibronectin type I domain
    pfam00041
    Location:1449 → 1528
    fn3; Fibronectin type III domain

  12. NM_001365524.2 → NP_001352453.1  fibronectin isoform 19 precursor

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    UniProtKB/TrEMBL
    A0A384MR03
    Conserved Domains (5) summary
    smart00059
    Location:353 → 401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186 → 230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:2174 → 2213
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00039
    Location:231 → 270
    fn1; Fibronectin type I domain
    pfam00041
    Location:1449 → 1528
    fn3; Fibronectin type III domain

  13. NM_002026.4 → NP_002017.2  fibronectin isoform 3 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    Consensus CDS
    CCDS2399.1
    UniProtKB/TrEMBL
    B7ZLE5
    Related
    ENSP00000338200.4, ENST00000336916.8

  14. NM_054034.3 → NP_473375.2  fibronectin isoform 7 preproprotein

    See identical proteins and their annotated locations for NP_473375.2

    Status: REVIEWED

    Source sequence(s)
    AC012462
    Consensus CDS
    CCDS46512.1
    UniProtKB/Swiss-Prot
    P02751
    Related
    ENSP00000398907.1, ENST00000426059.1
    Conserved Domains (4) summary
    smart00059
    Location:353 → 401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186 → 230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:52 → 89
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00039
    Location:231 → 270
    fn1; Fibronectin type I domain

  15. NM_212474.3 → NP_997639.2  fibronectin isoform 6 precursor

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    Consensus CDS
    CCDS2400.1
    UniProtKB/TrEMBL
    A0A384MR03
    Related
    ENSP00000350534.4, ENST00000357867.8

  16. NM_212476.3 → NP_997641.2  fibronectin isoform 5 precursor

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    Consensus CDS
    CCDS42813.1
    UniProtKB/TrEMBL
    B7ZLE5
    Related
    ENSP00000348285.4, ENST00000356005.8

  17. NM_212478.3 → NP_997643.2  fibronectin isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    Consensus CDS
    CCDS46510.1
    UniProtKB/TrEMBL
    B7ZLE5
    Related
    ENSP00000410422.1, ENST00000446046.5
    Conserved Domains (5) summary
    smart00059
    Location:353 → 401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186 → 230
    FN1; Fibronectin type 1 domain
    smart00060
    Location:1268 → 1347
    FN3; Fibronectin type 3 domain
    cd00061
    Location:2238 → 2277
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:1904 → 1984
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  18. NM_212482.4 → NP_997647.2  fibronectin isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    Consensus CDS
    CCDS42814.1
    UniProtKB/Swiss-Prot
    B7ZLF0, E9PE77, E9PG29, O95609, O95610, P02751, Q14312, Q14325, Q14326, Q17RV7, Q53S27, Q564H7, Q585T2, Q59EH1, Q60FE4, Q68DP8, Q68DP9, Q68DT4, Q6LDP6, Q6MZS0, Q6MZU5, Q6N025, Q6N0A6, Q7Z391, Q86T27, Q8IVI8, Q96KP7, Q96KP8, Q96KP9, Q9H1B8, Q9HAP3, Q9UMK2
    UniProtKB/TrEMBL
    B7ZLE5
    Related
    ENSP00000346839.4, ENST00000354785.11
    Conserved Domains (6) summary
    smart00059
    Location:353 → 401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186 → 230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:2385 → 2424
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:1995 → 2075
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231 → 270
    fn1; Fibronectin type I domain
    pfam00041
    Location:1540 → 1621
    fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    215360865..215436068 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    215845895..215921094 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_212475.1: Suppressed sequence

    Description
    NM_212475.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P02751.5 GenPept UniProtKB/Swiss-Prot:P02751

Gene LinkOut

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