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Lingo1 leucine rich repeat and Ig domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 235402, updated on 21-Apr-2024

Summary

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Official Symbol
Lingo1provided by MGI
Official Full Name
leucine rich repeat and Ig domain containing 1provided by MGI
Primary source
MGI:MGI:1915522
See related
Ensembl:ENSMUSG00000049556 AllianceGenome:MGI:1915522
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LERN1; Lrrn6a; UNQ201; LINGO-1; 4930471K13Rik
Summary
Enables epidermal growth factor receptor binding activity. Acts upstream of or within generation of neurons and protein kinase B signaling. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including branchial arch; central nervous system; gut; sensory organ; and somite. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability and glaucoma. Orthologous to human LINGO1 (leucine rich repeat and Ig domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 56.6), frontal lobe adult (RPKM 39.0) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 B; 9 30.28 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (56525743..56704355, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (56618460..56796310, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31529 Neighboring gene predicted gene, 26868 Neighboring gene STARR-positive B cell enhancer mm9_chr9:56484136-56484437 Neighboring gene STARR-seq mESC enhancer starr_24211 Neighboring gene predicted gene, 31642 Neighboring gene predicted gene, 53525 Neighboring gene predicted gene, 31586 Neighboring gene ciliary microtubule associated protein 1C Neighboring gene chondroitin sulfate proteoglycan 4 Neighboring gene STARR-positive B cell enhancer ABC_E10548 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:56776219-56776328 Neighboring gene sorting nexin 33

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. LINGO-1 deficiency promotes nerve regeneration through reduction of cell apoptosis, inflammation, and glial scar after spinal cord injury in mice. Huang LJ, et al. Exp Neurol, 2019 Oct. PMID 31132364
  2. Inhibition of LINGO-1 promotes functional recovery after experimental spinal cord demyelination. Zhang Y, et al. Exp Neurol, 2015 Apr. PMID 25681574
  3. Neutralization of LINGO-1 during in vitro differentiation of neural stem cells results in proliferation of immature neurons. Lööv C, et al. PLoS One, 2012. PMID 22235341, Free PMC Article
  4. LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis. Mi S, et al. Nat Med, 2007 Oct. PMID 17906634
  5. LINGO-1 shRNA protects the brain against ischemia/reperfusion injury by inhibiting the activation of NF-κB and JAK2/STAT3. Zhu J, et al. Hum Cell, 2021 Jul. PMID 33830473, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Antagonizing LINGO-1 reduces activated microglia and alleviates dendritic spine loss in the hippocampus of APP/PS1 transgenic mice.
    Title: Antagonizing LINGO-1 reduces activated microglia and alleviates dendritic spine loss in the hippocampus of APP/PS1 transgenic mice.
  2. LINGO-1 shRNA protects the brain against ischemia/reperfusion injury by inhibiting the activation of NF-kappaB and JAK2/STAT3.
    Title: LINGO-1 shRNA protects the brain against ischemia/reperfusion injury by inhibiting the activation of NF-κB and JAK2/STAT3.
  3. LINGO-1 regulates Wnt5a signaling during neural stem and progenitor cell differentiation by modulating miR-15b-3p levels.
    Title: LINGO-1 regulates Wnt5a signaling during neural stem and progenitor cell differentiation by modulating miR-15b-3p levels.
  4. results suggested that LINGO-1 plays a critical role in the injury microenvironment in processes such as cell death, inflammatory response, and glial scar formation after spinal cord injury
    Title: LINGO-1 deficiency promotes nerve regeneration through reduction of cell apoptosis, inflammation, and glial scar after spinal cord injury in mice.
  5. Myelin loss and subsequent axon degeneration contributes to a variety of neurological diseases, such as multiple sclerosis (MS).
    Title: LINGO-1 Regulates Oligodendrocyte Differentiation through the Cytoplasmic Gelsolin Signaling Pathway.
  6. These data provide morphometric and functional evidence of enhancement of remyelination associated with antagonism of LINGO-1
    Title: Inhibition of LINGO-1 promotes functional recovery after experimental spinal cord demyelination.
  7. LINGO-1, a transmembrane signaling protein, inhibits oligodendrocyte differentiation and myelination through intercellular self-interactions
    Title: LINGO-1, a transmembrane signaling protein, inhibits oligodendrocyte differentiation and myelination through intercellular self-interactions.
  8. a novel role for LINGO-1 in neural stem cell differentiation to neurons
    Title: Neutralization of LINGO-1 during in vitro differentiation of neural stem cells results in proliferation of immature neurons.
  9. Lingo1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis.
    Title: LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis.
  10. inhibitory agents of LINGO-1 activity can protect dopaminergic neurons against degeneration
    Title: Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables epidermal growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables epidermal growth factor receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within central nervous system neuron development IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within central nervous system neuron development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within neuron projection development IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Names
leucine-rich repeat neuronal protein 1
leucine-rich repeat neuronal protein 6A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311076.1 → NP_001298005.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001298005.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform.
    Source sequence(s)
    AC134578, AI425964, AK034084, BC052384, BQ174824, CJ057077, CO426272
    Consensus CDS
    CCDS81004.1
    UniProtKB/TrEMBL
    A9DA50
    Related
    ENSMUSP00000109894.2, ENSMUST00000114256.2
    Conserved Domains (6) summary
    TIGR00864
    Location:341 → 421
    PCC; polycystin cation channel protein
    smart00013
    Location:41 → 75
    LRRNT; Leucine rich repeat N-terminal domain
    COG4886
    Location:66 → 371
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:73 → 96
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:120 → 179
    LRR_8; Leucine rich repeat
    cd20969
    Location:423 → 514
    IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

  2. NM_001361115.1 → NP_001348044.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC126257, AC134578
    Consensus CDS
    CCDS23209.1
    UniProtKB/Swiss-Prot
    Q3TQJ4, Q6VVF9, Q7TT38, Q9D1T0
    Conserved Domains (6) summary
    TIGR00864
    Location:335 → 415
    PCC; polycystin cation channel protein
    smart00013
    Location:35 → 69
    LRRNT; Leucine rich repeat N-terminal domain
    COG4886
    Location:60 → 365
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:67 → 90
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:114 → 173
    LRR_8; Leucine rich repeat
    cd20969
    Location:417 → 508
    IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

  3. NM_001361116.1 → NP_001348045.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC126257, AC134578
    Consensus CDS
    CCDS23209.1
    UniProtKB/Swiss-Prot
    Q3TQJ4, Q6VVF9, Q7TT38, Q9D1T0
    Conserved Domains (6) summary
    TIGR00864
    Location:335 → 415
    PCC; polycystin cation channel protein
    smart00013
    Location:35 → 69
    LRRNT; Leucine rich repeat N-terminal domain
    COG4886
    Location:60 → 365
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:67 → 90
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:114 → 173
    LRR_8; Leucine rich repeat
    cd20969
    Location:417 → 508
    IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

  4. NM_001361117.1 → NP_001348046.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC126257, AC134578
    Consensus CDS
    CCDS23209.1
    UniProtKB/Swiss-Prot
    Q3TQJ4, Q6VVF9, Q7TT38, Q9D1T0
    Conserved Domains (6) summary
    TIGR00864
    Location:335 → 415
    PCC; polycystin cation channel protein
    smart00013
    Location:35 → 69
    LRRNT; Leucine rich repeat N-terminal domain
    COG4886
    Location:60 → 365
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:67 → 90
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:114 → 173
    LRR_8; Leucine rich repeat
    cd20969
    Location:417 → 508
    IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

  5. NM_001361118.1 → NP_001348047.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC126257, AC134578
    Consensus CDS
    CCDS23209.1
    UniProtKB/Swiss-Prot
    Q3TQJ4, Q6VVF9, Q7TT38, Q9D1T0
    Related
    ENSMUSP00000059050.2, ENSMUST00000053568.2
    Conserved Domains (6) summary
    TIGR00864
    Location:335 → 415
    PCC; polycystin cation channel protein
    smart00013
    Location:35 → 69
    LRRNT; Leucine rich repeat N-terminal domain
    COG4886
    Location:60 → 365
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:67 → 90
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:114 → 173
    LRR_8; Leucine rich repeat
    cd20969
    Location:417 → 508
    IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

  6. NM_001361119.1 → NP_001348048.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC126257, AC134578
    Consensus CDS
    CCDS23209.1
    UniProtKB/Swiss-Prot
    Q3TQJ4, Q6VVF9, Q7TT38, Q9D1T0
    Conserved Domains (6) summary
    TIGR00864
    Location:335 → 415
    PCC; polycystin cation channel protein
    smart00013
    Location:35 → 69
    LRRNT; Leucine rich repeat N-terminal domain
    COG4886
    Location:60 → 365
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:67 → 90
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:114 → 173
    LRR_8; Leucine rich repeat
    cd20969
    Location:417 → 508
    IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

  7. NM_001361120.1 → NP_001348049.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC126257, AC134578
    Consensus CDS
    CCDS23209.1
    UniProtKB/Swiss-Prot
    Q3TQJ4, Q6VVF9, Q7TT38, Q9D1T0
    Conserved Domains (6) summary
    TIGR00864
    Location:335 → 415
    PCC; polycystin cation channel protein
    smart00013
    Location:35 → 69
    LRRNT; Leucine rich repeat N-terminal domain
    COG4886
    Location:60 → 365
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:67 → 90
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:114 → 173
    LRR_8; Leucine rich repeat
    cd20969
    Location:417 → 508
    IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

  8. NM_181074.5 → NP_851419.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_851419.1

    Status: VALIDATED

    Source sequence(s)
    AC126257, AC134578
    Consensus CDS
    CCDS23209.1
    UniProtKB/Swiss-Prot
    Q3TQJ4, Q6VVF9, Q7TT38, Q9D1T0
    Related
    ENSMUSP00000148179.2, ENSMUST00000210032.2
    Conserved Domains (6) summary
    TIGR00864
    Location:335 → 415
    PCC; polycystin cation channel protein
    smart00013
    Location:35 → 69
    LRRNT; Leucine rich repeat N-terminal domain
    COG4886
    Location:60 → 365
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:67 → 90
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:114 → 173
    LRR_8; Leucine rich repeat
    cd20969
    Location:417 → 508
    IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    56525743..56704355 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154897.1 → XP_036010790.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q3TQJ4, Q6VVF9, Q7TT38, Q9D1T0
    Conserved Domains (6) summary
    TIGR00864
    Location:335 → 415
    PCC; polycystin cation channel protein
    smart00013
    Location:35 → 69
    LRRNT; Leucine rich repeat N-terminal domain
    COG4886
    Location:60 → 365
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:67 → 90
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:114 → 173
    LRR_8; Leucine rich repeat
    cd20969
    Location:417 → 508
    IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

  2. XM_030244328.2 → XP_030100188.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q3TQJ4, Q6VVF9, Q7TT38, Q9D1T0
    Conserved Domains (6) summary
    TIGR00864
    Location:335 → 415
    PCC; polycystin cation channel protein
    smart00013
    Location:35 → 69
    LRRNT; Leucine rich repeat N-terminal domain
    COG4886
    Location:60 → 365
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:67 → 90
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:114 → 173
    LRR_8; Leucine rich repeat
    cd20969
    Location:417 → 508
    IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

  3. XM_036154898.1 → XP_036010791.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q3TQJ4, Q6VVF9, Q7TT38, Q9D1T0
    Related
    ENSMUSP00000109885.2, ENSMUST00000114247.2
    Conserved Domains (6) summary
    TIGR00864
    Location:335 → 415
    PCC; polycystin cation channel protein
    smart00013
    Location:35 → 69
    LRRNT; Leucine rich repeat N-terminal domain
    COG4886
    Location:60 → 365
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:67 → 90
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:114 → 173
    LRR_8; Leucine rich repeat
    cd20969
    Location:417 → 508
    IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

  4. XM_030244330.2 → XP_030100190.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q3TQJ4, Q6VVF9, Q7TT38, Q9D1T0
    Conserved Domains (6) summary
    TIGR00864
    Location:335 → 415
    PCC; polycystin cation channel protein
    smart00013
    Location:35 → 69
    LRRNT; Leucine rich repeat N-terminal domain
    COG4886
    Location:60 → 365
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:67 → 90
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:114 → 173
    LRR_8; Leucine rich repeat
    cd20969
    Location:417 → 508
    IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

  5. XM_030244329.2 → XP_030100189.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q3TQJ4, Q6VVF9, Q7TT38, Q9D1T0
    Conserved Domains (6) summary
    TIGR00864
    Location:335 → 415
    PCC; polycystin cation channel protein
    smart00013
    Location:35 → 69
    LRRNT; Leucine rich repeat N-terminal domain
    COG4886
    Location:60 → 365
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:67 → 90
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:114 → 173
    LRR_8; Leucine rich repeat
    cd20969
    Location:417 → 508
    IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

  6. XM_036154899.1 → XP_036010792.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q3TQJ4, Q6VVF9, Q7TT38, Q9D1T0
    Conserved Domains (6) summary
    TIGR00864
    Location:335 → 415
    PCC; polycystin cation channel protein
    smart00013
    Location:35 → 69
    LRRNT; Leucine rich repeat N-terminal domain
    COG4886
    Location:60 → 365
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:67 → 90
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:114 → 173
    LRR_8; Leucine rich repeat
    cd20969
    Location:417 → 508
    IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

  7. XM_036154895.1 → XP_036010788.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q3TQJ4, Q6VVF9, Q7TT38, Q9D1T0
    Conserved Domains (6) summary
    TIGR00864
    Location:335 → 415
    PCC; polycystin cation channel protein
    smart00013
    Location:35 → 69
    LRRNT; Leucine rich repeat N-terminal domain
    COG4886
    Location:60 → 365
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:67 → 90
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:114 → 173
    LRR_8; Leucine rich repeat
    cd20969
    Location:417 → 508
    IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

  8. XM_036154896.1 → XP_036010789.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q3TQJ4, Q6VVF9, Q7TT38, Q9D1T0
    Conserved Domains (6) summary
    TIGR00864
    Location:335 → 415
    PCC; polycystin cation channel protein
    smart00013
    Location:35 → 69
    LRRNT; Leucine rich repeat N-terminal domain
    COG4886
    Location:60 → 365
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:67 → 90
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:114 → 173
    LRR_8; Leucine rich repeat
    cd20969
    Location:417 → 508
    IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

  9. XM_036154900.1 → XP_036010793.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q3TQJ4, Q6VVF9, Q7TT38, Q9D1T0
    Conserved Domains (6) summary
    TIGR00864
    Location:335 → 415
    PCC; polycystin cation channel protein
    smart00013
    Location:35 → 69
    LRRNT; Leucine rich repeat N-terminal domain
    COG4886
    Location:60 → 365
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:67 → 90
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:114 → 173
    LRR_8; Leucine rich repeat
    cd20969
    Location:417 → 508
    IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

  10. XM_006511086.3 → XP_006511149.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform X1

    Conserved Domains (6) summary
    TIGR00864
    Location:368 → 448
    PCC; polycystin cation channel protein
    smart00013
    Location:68 → 102
    LRRNT; Leucine rich repeat N-terminal domain
    COG4886
    Location:93 → 398
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:100 → 123
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:147 → 206
    LRR_8; Leucine rich repeat
    cl11960
    Location:466 → 541
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D1T0.1 GenPept UniProtKB/Swiss-Prot:Q9D1T0

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