Ghr growth hormone receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ghrprovided by RGD
Official Full Name: growth hormone receptorprovided by RGD
Primary source: RGD:2687
See related: Ensembl:ENSRNOG00000015654 AllianceGenome:RGD:2687
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: GHR/BP
Summary: Enables SH2 domain binding activity; enzyme binding activity; and growth hormone receptor activity. Involved in several processes, including activation of Janus kinase activity; cellular response to hormone stimulus; and receptor signaling pathway via JAK-STAT. Located in several cellular components, including extracellular space; mitochondrion; and neuronal cell body. Biomarker of congenital hypothyroidism; muscular atrophy; osteopetrosis; and osteoporosis. Human ortholog(s) of this gene implicated in several diseases, including Laron syndrome; familial hypercholesterolemia; isolated growth hormone deficiency; osteoarthritis; and type 2 diabetes mellitus. Orthologous to human GHR (growth hormone receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 1113.9), Heart (RPKM 432.6) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q16

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (54269066..54532595, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (52541452..52804960, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (53149225..53413954, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

receptor crosstalk between growth hormone and insulin signal in rats born small for gestational age with catch-up growth
Title: Post-receptor crosstalk between growth hormone and insulin signal in rats born small for gestational age with catch-up growth.
Compared to the rats in the control group, the rats in the HF group had the expression levels of 12 genes with significant changes, Agrp, Ghrl, and Nr3c1, Apoa4, Cntf, Ghr, IL-1beta, Ins1, Lepr,Sort, Adcyap1r1 and Adrb1.
Title: Green tea polyphenols reduce body weight in rats by modulating obesity-related genes.
The growth hormone receptor expression in the brain was lower during fetal period than in adults, while in the pituitary gland, the expression is markedly higher in fetuses, suggesting a yet unknown role of growth hormone in the development of this organ.
Title: Regional distribution and ontogeny of the first exon variants of the rat growth hormone receptor mRNA in the brain and the pituitary gland.
Growth hormone receptor mRNA levels decrease in hypothalamus during normal pregnancy while growth hormone expression rises in the pituitary.
Title: Importance of ghrelin in hypothalamus-pituitary axis on growth hormone release during normal pregnancy in the rat.
Data show that TrCP acts in an early stage of cargo selection: both TrCP silencing and mutation of the ubiquitin-dependent endocytosis motif force the GHR to recycle between endosomes and the plasma membrane.
Title: SCF(TrCP) acts in endosomal sorting of the GH receptor.
GH and its receptor have roles in injury-induced neurogenesis
Title: Growth hormone receptor immunoreactivity is increased in the subventricular zone of juvenile rat brain after focal ischemia: a potential role for growth hormone in injury-induced neurogenesis.
Insulin signaling via either the PI-3 kinase or MEK/ERK pathway may result in partial reduction of GHR gene expression, whereas signaling via both pathways may be required to achieve the full insulin effect.
Title: Insulin regulation of growth hormone receptor gene expression: involvement of both the PI-3 kinase and MEK/ERK signaling pathways.
These findings indicate that the heterologous reduction of GHR by insulin occurs via transcriptional downregulation, and the homologous reduction of GHR by GH occurs via a different mechanism.
Title: Insulin regulation of growth hormone receptor gene expression. Evidence for a transcriptional mechanism of down-regulation in rat hepatoma cells.
localization in growth plate
Title: Localization and regulation of the growth hormone receptor and growth hormone-binding protein in the rat growth plate.
findings demonstrate the interaction of cytokine-induced Src homology domain 2 protein(CIS) with the growth hormone receptor in vivo and suggest that CIS may enhance degradation of the receptor by a proteasomal pathway
Title: Interaction of the growth hormone receptor with cytokine-induced Src homology domain 2 protein in rat adipocytes.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH142196 (e-PCR)
- UniSTS:231446

RH141289 (e-PCR)
- UniSTS:223285

Ghr (e-PCR), detects polymorphism
- UniSTS:143202

D2Chm149 (e-PCR)
- UniSTS:518043

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SH2 domain binding	IDA Inferred from Direct Assay more info	PubMed
enables SH2 domain binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables SH2 domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables cytokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor binding	ISO Inferred from Sequence Orthology more info
enables growth hormone receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth hormone receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables growth hormone receptor activity	ISO Inferred from Sequence Orthology more info
enables growth hormone receptor activity	TAS Traceable Author Statement more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cartilage development involved in endochondral bone morphogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in growth hormone receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in growth hormone receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in growth hormone receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in hormone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in hormone-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in insulin-like growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of cell differentiation	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of response to nutrient levels	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in response to cycloheximide	ISO Inferred from Sequence Orthology more info
involved_in response to cycloheximide	ISO Inferred from Sequence Orthology more info
involved_in response to cytokine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	ISO Inferred from Sequence Orthology more info
involved_in response to food	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to gravity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to growth hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to interleukin-1	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_positive_effect taurine metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic ribonucleoprotein granule	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of growth hormone receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of growth hormone receptor complex	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: growth hormone receptor

Names: GH receptor; growth hormone receptor variant d5-6; growth hormone receptor/binding protein; somatotropin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017094.2 → NP_058790.1 growth hormone receptor precursor

See identical proteins and their annotated locations for NP_058790.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

P16310, Q64236, Q80XW9

UniProtKB/TrEMBL

A6KGC0, I1SRC4

Related

ENSRNOP00000044119.3, ENSRNOT00000046951.6

Conserved Domains (3) summary

cd00063
Location:149 → 250

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam12772
Location:317 → 616

GHBP; Growth hormone receptor binding

cl21522
Location:49 → 127

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

54269066..54532595 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008760754.3 → XP_008758976.1 growth hormone receptor isoform X1

See identical proteins and their annotated locations for XP_008758976.1

UniProtKB/Swiss-Prot

P16310, Q64236, Q80XW9

UniProtKB/TrEMBL

A6KGC0, I1SRC4

Conserved Domains (3) summary

cd00063
Location:149 → 250

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam12772
Location:317 → 616

GHBP; Growth hormone receptor binding

cl21522
Location:49 → 127

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_063281321.1 → XP_063137391.1 growth hormone receptor isoform X1

UniProtKB/Swiss-Prot

P16310, Q64236, Q80XW9

UniProtKB/TrEMBL

A6KGC0
XM_039101770.2 → XP_038957698.1 growth hormone receptor isoform X1

UniProtKB/Swiss-Prot

P16310, Q64236, Q80XW9

UniProtKB/TrEMBL

A6KGC0, I1SRC4

Conserved Domains (3) summary

cd00063
Location:149 → 250

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam12772
Location:317 → 616

GHBP; Growth hormone receptor binding

cl21522
Location:49 → 127

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_039101769.2 → XP_038957697.1 growth hormone receptor isoform X1

UniProtKB/Swiss-Prot

P16310, Q64236, Q80XW9

UniProtKB/TrEMBL

A6KGC0, I1SRC4

Conserved Domains (3) summary

cd00063
Location:149 → 250

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam12772
Location:317 → 616

GHBP; Growth hormone receptor binding

cl21522
Location:49 → 127

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_039101771.2 → XP_038957699.1 growth hormone receptor isoform X2

UniProtKB/TrEMBL

A0A0H2UHM8, Q5RJL5

Related

ENSRNOP00000021081.6

Conserved Domains (2) summary

cd00063
Location:149 → 250

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:49 → 127

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_063281322.1 → XP_063137392.1 growth hormone receptor isoform X2

UniProtKB/TrEMBL

Q5RJL5
XM_063281324.1 → XP_063137394.1 growth hormone receptor isoform X2

UniProtKB/TrEMBL

Q5RJL5
XM_063281323.1 → XP_063137393.1 growth hormone receptor isoform X2

UniProtKB/TrEMBL

Q5RJL5