P2ry1 purinergic receptor P2Y1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: P2ry1provided by RGD
Official Full Name: purinergic receptor P2Y1provided by RGD
Primary source: RGD:3242
See related: Ensembl:ENSRNOG00000014232 AllianceGenome:RGD:3242
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: P2y; P2y1
Summary: Enables several functions, including A1 adenosine receptor binding activity; G protein-coupled purinergic nucleotide receptor activity; and adenyl ribonucleotide binding activity. Involved in several processes, including purinergic nucleotide receptor signaling pathway; regulation of cytosolic calcium ion concentration; and regulation of secretion by cell. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and postsynaptic density. Is active in glutamatergic synapse. Is integral component of presynaptic active zone membrane. Colocalizes with mitochondrion. Used to study impotence. Orthologous to human P2RY1 (purinergic receptor P2Y1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 119.4), Spleen (RPKM 41.7) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q31

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (147391661..147397870)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (145241975..145248186)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (151314818..151320312)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

P2Y1 and P2Y2 receptors differ in their role in the regulation of signaling pathways during unloading-induced rat soleus muscle atrophy.
Title: P2Y1 and P2Y2 receptors differ in their role in the regulation of signaling pathways during unloading-induced rat soleus muscle atrophy.
Abeta1-42 peptides blunt the adenosine A2A receptor-mediated control of the interplay between P2X7 and P2Y1 receptors mediated calcium responses in astrocytes.
Title: Aβ(1-42) peptides blunt the adenosine A(2A) receptor-mediated control of the interplay between P(2)X(7) and P(2)Y(1) receptors mediated calcium responses in astrocytes.
Transcutaneous auricular vagal nerve stimulation inhibits hypothalamic P2Y1R expression and attenuates weight gain without decreasing food intake in Zucker diabetic fatty rats.
Title: Transcutaneous auricular vagal nerve stimulation inhibits hypothalamic P2Y1R expression and attenuates weight gain without decreasing food intake in Zucker diabetic fatty rats.
P2Y1 Purinergic Receptor Contributes to Remifentanil-Induced Cold Hyperalgesia via Transient Receptor Potential Melastatin 8-Dependent Regulation of N-methyl-d-aspartate Receptor Phosphorylation in Dorsal Root Ganglion.
Title: P2Y1 Purinergic Receptor Contributes to Remifentanil-Induced Cold Hyperalgesia via Transient Receptor Potential Melastatin 8-Dependent Regulation of N-methyl-d-aspartate Receptor Phosphorylation in Dorsal Root Ganglion.
A Role for The P2Y1 Receptor in Nonsynaptic Cross-depolarization in the Rat Dorsal Root Ganglia.
Title: A Role for The P2Y1 Receptor in Nonsynaptic Cross-depolarization in the Rat Dorsal Root Ganglia.
ATP/ADP through the activation of P2Y1R contributes to glutamate-induced neuronal death in the rat hippocampus.
Title: Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation.
P2Y1R plays a regulatory role in visceral hypersensitivity in rats with experimental irritable bowel syndrome.
Title: P2Y1R is involved in visceral hypersensitivity in rats with experimental irritable bowel syndrome.
These data are supporting the idea of a dynamic modulation of astrocytic processes by purinergic signal, strengthening the role of purines in brain homeostasis.
Title: Purinergic P2Y1 Receptors Control Rapid Expression of Plasma Membrane Processes in Hippocampal Astrocytes.
Data indicate the involvement of P2Y1Rs in interleukin-1beta (IL-1beta) mediated pain in both naive and carrageenan injected rats. There is a positive interaction between peripheral P2Y1Rs and interleukin-1 receptors in both IL-1beta and carrageenan-induced thermal hypersensitivity.
Title: Involvement of peripheral P2Y1 receptors and potential interaction with IL-1 receptors in IL-1β-induced thermal hypersensitivity in rats.
Synergistic inhibition of both P2Y1 and P2Y12 adenosine diphosphate receptors by GLS-409 immediately attenuates platelet-mediated thrombosis and effectively blocks agonist-stimulated platelet aggregation irrespective of concomitant aspirin therapy.
Title: Synergistic Inhibition of Both P2Y1 and P2Y12 Adenosine Diphosphate Receptors As Novel Approach to Rapidly Attenuate Platelet-Mediated Thrombosis.

Submit: New GeneRIF Correction See all GeneRIFs (64)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC34459P1 (e-PCR)
- UniSTS:273207

PMC123072P2 (e-PCR)
- UniSTS:270435

BE117641 (e-PCR)
- UniSTS:248705

BF405988 (e-PCR)
- UniSTS:247981

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables A1 adenosine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables A1 adenosine receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables ADP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables G protein-coupled ADP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled ADP receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled ADP receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled ATP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled ATP receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled purinergic nucleotide receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled purinergic nucleotide receptor activity	TAS Traceable Author Statement more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables scaffold protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled adenosine receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled purinergic nucleotide receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in blood vessel diameter maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
involved_in cellular response to purine-containing compound	ISO Inferred from Sequence Orthology more info
involved_in cellular response to purine-containing compound	ISS Inferred from Sequence or Structural Similarity more info
involved_in eating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in glial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in microglial cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of monoatomic ion transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of norepinephrine secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in platelet activation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hormone secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of inositol trisphosphate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of monoatomic ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of penile erection	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of presynaptic cytosolic calcium ion concentration	EXP Inferred from Experiment more info	PubMed
involved_in regulation of presynaptic cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of presynaptic cytosolic calcium ion concentration	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of synaptic vesicle exocytosis	EXP Inferred from Experiment more info	PubMed
involved_in regulation of synaptic vesicle exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle exocytosis	IEP Inferred from Expression Pattern more info	PubMed
involved_in relaxation of muscle	IEA Inferred from Electronic Annotation more info
involved_in response to growth factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mechanical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction involved in regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: P2Y purinoceptor 1

Names: ATP receptor; P2 purinoreceptor subclass 2Y; P2Y ATP receptor 1; purinergic receptor P2Y, G-protein coupled, 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.