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Khk ketohexokinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 25659, updated on 5-Mar-2024

Summary

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Official Symbol
Khkprovided by RGD
Official Full Name
ketohexokinaseprovided by RGD
Primary source
RGD:2966
See related
Ensembl:ENSRNOG00000008047 AllianceGenome:RGD:2966
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
KETHPRO
Summary
Enables ketohexokinase activity. Involved in several processes, including response to hexose; response to insulin; and response to sucrose. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in essential fructosuria. Orthologous to human KHK (ketohexokinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 1105.1) and Liver (RPKM 877.2) See more
Orthologs
human mouse all
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Genomic context

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Location:
6q14
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (31165246..31175779, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (25445298..25455834, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (26810577..26821013, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene prolactin regulatory element binding Neighboring gene abhydrolase domain containing 1 Neighboring gene cell growth regulator with EF hand domain 1 Neighboring gene elastin microfibril interfacer 1 Neighboring gene oligosaccharyltransferase complex subunit 4, non-catalytic Neighboring gene AGBL carboxypeptidase 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Reduction of liver fructokinase expression and improved hepatic inflammation and metabolism in liquid fructose-fed rats after atorvastatin treatment. Vilà L, et al. Toxicol Appl Pharmacol, 2011 Feb 15. PMID 21122807
  2. Liver AMP/ATP ratio and fructokinase expression are related to gender differences in AMPK activity and glucose intolerance in rats ingesting liquid fructose. Vilà L, et al. J Nutr Biochem, 2011 Aug. PMID 21115336
  3. Fructokinase activity in rat liver, ileum, parotid gland, pancreas, pancreatic islet, B and non-B islet cell homogenates. Giroix MH, et al. Int J Mol Med, 2006 Mar. PMID 16465401
  4. Expression of rat liver ketohexokinase in yeast results in fructose intolerance. Donaldson IA, et al. Biochem J, 1993 Apr 1. PMID 8471037, Free PMC Article
  5. Effect of aging on changes in substrate and effector levels of rat-liver glycolytic and lipogenic enzymes during induction. Fukuda H, et al. Biochim Biophys Acta, 1984 Aug 15. PMID 6147160

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Liver expression of the enzyme fructokinase, controlling fructose metabolism, was markedly induced by fructose ingestion in female, but not in male rats.
    Title: Liver AMP/ATP ratio and fructokinase expression are related to gender differences in AMPK activity and glucose intolerance in rats ingesting liquid fructose.
  2. Atorvastatin decreased the expression of fructokinase in livers of fructose-supplemented rats, reducing the metabolic burden on the liver that is imposed by continuous fructose ingestion.
    Title: Reduction of liver fructokinase expression and improved hepatic inflammation and metabolism in liquid fructose-fed rats after atorvastatin treatment.
  3. The present study provides information on the activity of Fructokinase in islets relative to that in other tissues and on the respective contribution of insulin-producing B cells and non-B islet cells.
    Title: Fructokinase activity in rat liver, ileum, parotid gland, pancreas, pancreatic islet, B and non-B islet cell homogenates.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ketohexokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ketohexokinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ketohexokinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ketohexokinase activity ISO
Inferred from Sequence Orthology
more info
  
enables ketohexokinase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbohydrate catabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in carbohydrate phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in fructose catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate ISO
Inferred from Sequence Orthology
more info
  
involved_in fructose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fructose metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fructose metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fructose metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of glycogen metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of glycogen metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to fructose IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to fructose IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to glucose IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to glucose IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to insulin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to insulin IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to sucrose IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to sucrose IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to zinc ion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to zinc ion IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ketohexokinase
Names
hepatic fructokinase
NP_114061.1
XP_006239852.1
XP_017449536.1
XP_017449537.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031855.3 → NP_114061.1  ketohexokinase

    See identical proteins and their annotated locations for NP_114061.1

    Status: PROVISIONAL

    Source sequence(s)
    BC078752
    UniProtKB/Swiss-Prot
    P97550, P97551, Q02974
    UniProtKB/TrEMBL
    A0A8L2QMK2, A6HAB0
    Related
    ENSRNOP00000046296.4, ENSRNOT00000043572.4
    Conserved Domains (1) summary
    cd01939
    Location:5 → 295
    Ketohexokinase; Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to fructose-1-phosphate (F1P), the first step in the metabolism of dietary fructose. KHK can also phosphorylate several other furanose sugars. It is found in higher eukaryotes ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    31165246..31175779 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017594047.2 → XP_017449536.1  ketohexokinase isoform X2

    UniProtKB/TrEMBL
    A6HAA9
    Conserved Domains (1) summary
    cd01939
    Location:5 → 250
    Ketohexokinase; Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to fructose-1-phosphate (F1P), the first step in the metabolism of dietary fructose. KHK can also phosphorylate several other furanose sugars. It is found in higher eukaryotes ...

  2. XM_006239790.4 → XP_006239852.1  ketohexokinase isoform X1

    Related
    ENSRNOP00000095511.1, ENSRNOT00000114876.1
    Conserved Domains (1) summary
    cd01939
    Location:5 → 295
    Ketohexokinase; Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to fructose-1-phosphate (F1P), the first step in the metabolism of dietary fructose. KHK can also phosphorylate several other furanose sugars. It is found in higher eukaryotes ...

  3. XM_017594048.2 → XP_017449537.1  ketohexokinase isoform X3

    UniProtKB/TrEMBL
    A0A8I6G7X9
    Related
    ENSRNOP00000081407.1, ENSRNOT00000104499.1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02974.1 GenPept UniProtKB/Swiss-Prot:Q02974

Gene LinkOut

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