Soat2 sterol O-acyltransferase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Soat2provided by RGD
Official Full Name: sterol O-acyltransferase 2provided by RGD
Primary source: RGD:628865
See related: Ensembl:ENSRNOG00000053769 AllianceGenome:RGD:628865
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Acat-2
Summary: Enables sterol O-acyltransferase activity. Involved in cholesterol metabolic process and response to nutrient. Located in endoplasmic reticulum. Used to study end stage renal disease. Biomarker of nephrotic syndrome. Human ortholog(s) of this gene implicated in coronary artery disease and hepatocellular carcinoma. Orthologous to human SOAT2 (sterol O-acyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 154.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 7q36

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (135160424..135173521)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (133281818..133294915)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (143754892..143767989)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression levels of hepatic ACAT2 (Soat2) were significantly increased following a high fructose diet.
Title: High-Fructose Diet-Induced Hypertriglyceridemia Is Associated With Enhanced Hepatic Expression of ACAT2 in Rats.
ACAT-2 isozyme is responsible for the increased intestinal ACAT activity of diabetic rats, suggesting an important role of ACAT-2 for dyslipidemia in diabetic patients.
Title: Acyl-coenzyme A:cholesterol acyltransferase-2 (ACAT-2) is responsible for elevated intestinal ACAT activity in diabetic rats.
increasing DGAT1, ACAT1, or ACAT2 expression stimulates the assembly and secretion of VLDL from liver cells
Title: Overexpression of human diacylglycerol acyltransferase 1, acyl-coa:cholesterol acyltransferase 1, or acyl-CoA:cholesterol acyltransferase 2 stimulates secretion of apolipoprotein B-containing lipoproteins in McA-RH7777 cells.

Submit: New GeneRIF Correction

General gene information

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Markers

D7Rat93 (e-PCR), detects polymorphism
- UniSTS:119068

RH131180 (e-PCR)
- UniSTS:214463

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cholesterol O-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cholesterol O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables cholesterol O-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables cholesterol binding	IBA Inferred from Biological aspect of Ancestor more info
enables cholesterol binding	IEA Inferred from Electronic Annotation more info
enables cholesterol binding	ISO Inferred from Sequence Orthology more info
enables fatty-acyl-CoA binding	IBA Inferred from Biological aspect of Ancestor more info
enables fatty-acyl-CoA binding	IEA Inferred from Electronic Annotation more info
enables fatty-acyl-CoA binding	ISO Inferred from Sequence Orthology more info
enables sterol O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables sterol O-acyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cholesterol efflux	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol efflux	IEA Inferred from Electronic Annotation more info
involved_in cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in cholesterol homeostasis	IEA Inferred from Electronic Annotation more info
involved_in cholesterol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol storage	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cholesterol storage	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in very-low-density lipoprotein particle assembly	IEA Inferred from Electronic Annotation more info
involved_in very-low-density lipoprotein particle assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in brush border	IEA Inferred from Electronic Annotation more info
located_in brush border	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sterol O-acyltransferase 2

Names: acyl-CoA:cholesterol acyltransferase 2; acyl-coenzyme A:cholesterol acyltransferase 2; cholesterol acyltransferase 2

NP_714950.3

EC 2.3.1.26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153728.3 → NP_714950.3 sterol O-acyltransferase 2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

Q7TQM4

UniProtKB/TrEMBL

A6KCT0, G3V7I6

Related

ENSRNOP00000071253.1, ENSRNOT00000085896.2

Conserved Domains (1) summary

pfam03062
Location:268 → 496

MBOAT; membrane-bound O-acyltransferase family