Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mtrrprovided by RGD
Official Full Name: 5-methyltetrahydrofolate-homocysteine methyltransferase reductaseprovided by RGD
Primary source: RGD:1308671
See related: Ensembl:ENSRNOG00000017826 AllianceGenome:RGD:1308671
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MSR
Summary: Predicted to enable NADPH-hemoprotein reductase activity; [methionine synthase] reductase activity; and nucleotide binding activity. Predicted to be involved in several processes, including S-adenosylmethionine cycle; carboxylic acid metabolic process; and negative regulation of cystathionine beta-synthase activity. Predicted to be located in intermediate filament cytoskeleton and nucleoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in several diseases, including endocrine gland cancer (multiple); heart disease (multiple); hematologic cancer (multiple); homocystinuria; and homocystinuria-megaloblastic anemia cblE type. Orthologous to human MTRR (5-methyltetrahydrofolate-homocysteine methyltransferase reductase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 120.0), Muscle (RPKM 107.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1p11

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (36695376..36727341)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (34866991..34899425)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (37743089..37774485)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables FAD binding	ISO Inferred from Sequence Orthology more info
enables FMN binding	IBA Inferred from Biological aspect of Ancestor more info
enables FMN binding	IEA Inferred from Electronic Annotation more info
enables FMN binding	ISO Inferred from Sequence Orthology more info
enables NADPH binding	ISO Inferred from Sequence Orthology more info
enables NADPH-hemoprotein reductase activity	ISO Inferred from Sequence Orthology more info
enables [methionine synthase] reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables [methionine synthase] reductase activity	ISO Inferred from Sequence Orthology more info
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	ISO Inferred from Sequence Orthology more info
enables flavin adenine dinucleotide binding	ISS Inferred from Sequence or Structural Similarity more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in S-adenosylmethionine cycle	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in cobalamin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in folic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in folic acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in homocysteine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in homocysteine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in homocysteine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in methionine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in methionine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in methionine biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intermediate filament cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in intermediate filament cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: methionine synthase reductase

Names: aqCbl reductase; aquacobalamin reductase

NP_001034092.1

EC 1.16.1.8

XP_006227875.1

EC 1.16.1.8

XP_006227876.1

EC 1.16.1.8

XP_038958809.1

EC 1.16.1.8

XP_038958835.1

EC 1.16.1.8

XP_063138780.1

EC 1.16.1.8

XP_063138782.1

EC 1.16.1.8

XP_063138783.1

EC 1.16.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039003.1 → NP_001034092.1 methionine synthase reductase

See identical proteins and their annotated locations for NP_001034092.1

Status: PROVISIONAL

Source sequence(s)

BC100107

UniProtKB/Swiss-Prot

Q498R1

Related

ENSRNOP00000058505.2, ENSRNOT00000061790.4

Conserved Domains (3) summary

cd06203
Location:84 → 505

methionine_synthase_red; Human methionine synthase reductase (MSR) restores methionine sythase which is responsible for the regeneration of methionine from homocysteine, as well as the coversion of methyltetrahydrofolate to tetrahydrofolate. In MSR, electrons are transferred ...

COG0369
Location:90 → 505

CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]

pfam00258
Location:6 → 46

Flavodoxin_1; Flavodoxin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

36695376..36727341

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006227813.5 → XP_006227875.1 methionine synthase reductase isoform X1

See identical proteins and their annotated locations for XP_006227875.1

UniProtKB/Swiss-Prot

D3ZDG8, Q498R1

UniProtKB/TrEMBL

A0A8L2QCU1

Related

ENSRNOP00000078665.1

Conserved Domains (2) summary

cd06203
Location:278 → 699

methionine_synthase_red; Human methionine synthase reductase (MSR) restores methionine sythase which is responsible for the regeneration of methionine from homocysteine, as well as the coversion of methyltetrahydrofolate to tetrahydrofolate. In MSR, electrons are transferred ...

pfam00258
Location:6 → 142

Flavodoxin_1
XM_063282712.1 → XP_063138782.1 methionine synthase reductase isoform X4
XM_063282710.1 → XP_063138780.1 methionine synthase reductase isoform X1

UniProtKB/Swiss-Prot

D3ZDG8, Q498R1
XM_063282713.1 → XP_063138783.1 methionine synthase reductase isoform X5
XM_039102881.2 → XP_038958809.1 methionine synthase reductase isoform X2

UniProtKB/TrEMBL

A0A8L2QCU1

Related

ENSRNOP00000024041.3

Conserved Domains (2) summary

cd06203
Location:224 → 645

methionine_synthase_red; Human methionine synthase reductase (MSR) restores methionine sythase which is responsible for the regeneration of methionine from homocysteine, as well as the coversion of methyltetrahydrofolate to tetrahydrofolate. In MSR, electrons are transferred ...

pfam00258
Location:2 → 88

Flavodoxin_1
XM_006227814.4 → XP_006227876.1 methionine synthase reductase isoform X3

See identical proteins and their annotated locations for XP_006227876.1

UniProtKB/TrEMBL

A0A8L2QCU1

Conserved Domains (1) summary

cd06203
Location:155 → 576

methionine_synthase_red; Human methionine synthase reductase (MSR) restores methionine sythase which is responsible for the regeneration of methionine from homocysteine, as well as the coversion of methyltetrahydrofolate to tetrahydrofolate. In MSR, electrons are transferred ...
XM_039102907.2 → XP_038958835.1 methionine synthase reductase isoform X5

UniProtKB/TrEMBL

A0A8L2QCU1

Conserved Domains (1) summary

cd06203
Location:116 → 537

methionine_synthase_red; Human methionine synthase reductase (MSR) restores methionine sythase which is responsible for the regeneration of methionine from homocysteine, as well as the coversion of methyltetrahydrofolate to tetrahydrofolate. In MSR, electrons are transferred ...