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suclg2 succinate-CoA ligase GDP-forming subunit beta [ Danio rerio (zebrafish) ]

Gene ID: 317746, updated on 27-Mar-2024

Summary

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Official Symbol
suclg2provided by ZNC
Official Full Name
succinate-CoA ligase GDP-forming subunit betaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030114-3
See related
Ensembl:ENSDARG00000044914 AllianceGenome:ZFIN:ZDB-GENE-030114-3
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb625; fd44e06; wu:fd44e06
Summary
Predicted to enable succinate-CoA ligase (GDP-forming) activity. Predicted to be involved in succinyl-CoA metabolic process and tricarboxylic acid cycle. Predicted to be part of succinate-CoA ligase complex. Predicted to be active in mitochondrion. Is expressed in lens; liver; pronephric duct; solid lens vesicle; and yolk syncytial layer. Orthologous to human SUCLG2 (succinate-CoA ligase GDP-forming subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 11
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (16738158..16975059, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (16603523..16840447, complement)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100151192 Neighboring gene kelch repeat and BTB (POZ) domain containing 8 Neighboring gene si:dkeyp-33e11.1 Neighboring gene family with sequence similarity 19 member A1, C-C motif chemokine like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Effects of starch-coating of magnetite nanoparticles on cellular uptake, toxicity and gene expression profiles in adult zebrafish. Zheng M, et al. Sci Total Environ, 2018 May 1. PMID 29227944
  2. Single and joint toxic effects of four antibiotics on some metabolic pathways of zebrafish (Danio rerio) larvae. Qiu W, et al. Sci Total Environ, 2020 May 10. PMID 32036144
  3. Zebrafish znfl1s regulate left-right asymmetry patterning through controlling the expression of fgfr1a. Li J, et al. J Cell Physiol, 2019 Mar. PMID 30317609
  4. Thifluzamide induces the toxic effects on zebrafish (Danio rerio) via inhibition of succinate dehydrogenase (SDH). Yang Y, et al. Environ Pollut, 2020 Oct. PMID 32806454
  5. Temporal pattern of loss/persistence of duplicate genes involved in signal transduction and metabolic pathways after teleost-specific genome duplication. Sato Y, et al. BMC Evol Biol, 2009 Jun 5. PMID 19500364, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables succinate-CoA ligase (ADP-forming) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables succinate-CoA ligase (GDP-forming) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables succinate-CoA ligase (GDP-forming) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in succinyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within succinyl-CoA metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of succinate-CoA ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial; succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
Names
SUCLGb
succinate-CoA ligase, GDP-forming, beta subunit
XP_001923821.2
XP_021328137.1
XP_021335446.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001386309.1 → NP_001373238.1  succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial

    Status: VALIDATED

    Source sequence(s)
    CR847506, CT955969
    UniProtKB/TrEMBL
    A0A8M1QKY6, A0A8M9QHZ9, F1R7X5
    Conserved Domains (1) summary
    PRK00696
    Location:39 → 420
    sucC; ADP-forming succinate--CoA ligase subunit beta

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    16738158..16975059 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021479771.1 → XP_021335446.1  succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform X1

    Related
    ENSDARP00000107576.1, ENSDART00000122222.3
    Conserved Domains (1) summary
    PRK00696
    Location:39 → 420
    sucC; ADP-forming succinate--CoA ligase subunit beta

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394810.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    250752..452042 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021472462.1 → XP_021328137.1  succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A0A8M1QKY6, A0A8M9PAQ3
    Conserved Domains (1) summary
    PRK00696
    Location:60 → 441
    sucC; succinyl-CoA synthetase subunit beta; Provisional

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395298.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    16433..247936 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001923786.6 → XP_001923821.2  succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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