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Ahcy Adenosylhomocysteinase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32471, updated on 4-Apr-2024

Summary

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Official Symbol
Ahcyprovided by FlyBase
Official Full Name
Adenosylhomocysteinaseprovided by FlyBase
Primary source
FLYBASE:FBgn0014455
Locus tag
Dmel_CG11654
See related
AllianceGenome:FB:FBgn0014455
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ahcY; Ahcy13; CG11654; Dmel\CG11654; SAHH
Summary
Predicted to enable adenosylhomocysteinase activity. Involved in S-adenosylhomocysteine catabolic process. Predicted to be active in cytosol. Is expressed in several structures, including anterior endoderm; embryonic/larval lymph gland; embryonic/larval muscle system; extended germ band embryo; and gut section. Human ortholog(s) of this gene implicated in hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase. Orthologous to human AHCY (adenosylhomocysteinase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
13C3-13C3; 1-50 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15450261..15453167)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15344294..15347200)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Cyclic nucleotide-gated ion channel-like Neighboring gene scamp Neighboring gene uncharacterized protein Neighboring gene shattered Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The S-adenosyl-L-homocysteine hydrolase of Drosophila melanogaster: identification, deduced amino acid sequence and cytological localization of the structural gene. Caggese C, et al. Mol Gen Genet, 1997 Jan 27. PMID 9037110
  2. The Transcriptional Corepressor SIN3 Directly Regulates Genes Involved in Methionine Catabolism and Affects Histone Methylation, Linking Epigenetics and Metabolism. Liu M, et al. J Biol Chem, 2017 Feb 3. PMID 28028175, Free PMC Article
  3. How tissue damage MET metabolism: Regulation of the systemic damage response. Kashio S, et al. Fly (Austin), 2017 Jan 2. PMID 27562340, Free PMC Article
  4. Disruption of Methionine Metabolism in Drosophila melanogaster Impacts Histone Methylation and Results in Loss of Viability. Liu M, et al. G3 (Bethesda), 2015 Nov 6. PMID 26546310, Free PMC Article
  5. CLOCKWORK ORANGE promotes CLOCK-CYCLE activation via the putative Drosophila ortholog of CLOCK INTERACTING PROTEIN CIRCADIAN. Rivas GBS, et al. Curr Biol, 2021 Oct 11. PMID 34331859, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables adenosylhomocysteinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenosylhomocysteinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in S-adenosylhomocysteine catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in S-adenosylmethionine cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
adenosylhomocysteinase
Names
AdoHcyase
Ahcy-PA
Ahcy-PB
Ahcy-PC
CG11654-PA
CG11654-PB
CG11654-PC
S-Adenosyl-L-homocysteine hydrolase
adenosylhomocysteinase at 13
adenosylhomocysteinases
NP_001259573.1
NP_001285268.1
NP_511164.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    15450261..15453167
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298339.1 → NP_001285268.1  adenosylhomocysteinase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285268.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q27580, Q8MZI1, Q9VXV5
    UniProtKB/TrEMBL
    X2JF40
    Conserved Domains (2) summary
    PRK05476
    Location:1 → 426
    PRK05476; S-adenosyl-L-homocysteine hydrolase; Provisional
    pfam05221
    Location:6 → 431
    AdoHcyase; S-adenosyl-L-homocysteine hydrolase

  2. NM_078609.4 → NP_511164.2  adenosylhomocysteinase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_511164.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q27580, Q8MZI1, Q9VXV5
    UniProtKB/TrEMBL
    X2JF40
    Related
    FBpp0073847
    Conserved Domains (2) summary
    PRK05476
    Location:1 → 426
    PRK05476; S-adenosyl-L-homocysteine hydrolase; Provisional
    pfam05221
    Location:6 → 431
    AdoHcyase; S-adenosyl-L-homocysteine hydrolase

  3. NM_001272644.1 → NP_001259573.1  adenosylhomocysteinase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259573.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PHN8
    Conserved Domains (2) summary
    PRK05476
    Location:2 → 317
    PRK05476; S-adenosyl-L-homocysteine hydrolase; Provisional
    cl21454
    Location:2 → 322
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PHN8 M9PHN8
Q27580.2 Q27580
X2JF40 X2JF40

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