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Gcdh glutaryl-CoA dehydrogenase [ Rattus norvegicus (Norway rat) ]

Gene ID: 364975, updated on 11-Apr-2024

Summary

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Official Symbol
Gcdhprovided by RGD
Official Full Name
glutaryl-CoA dehydrogenaseprovided by RGD
Primary source
RGD:1308829
See related
Ensembl:ENSRNOG00000003307 AllianceGenome:RGD:1308829
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables fatty-acyl-CoA binding activity; flavin adenine dinucleotide binding activity; and glutaryl-CoA dehydrogenase activity. Involved in fatty acid oxidation and fatty-acyl-CoA biosynthetic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in glutaric acidemia I. Orthologous to human GCDH (glutaryl-CoA dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 1777.2), Liver (RPKM 1242.1) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
19q11
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (40168038..40174536)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (23263215..23269689)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (26000497..26006970, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene deoxyribonuclease 2, lysosomal Neighboring gene KLF transcription factor 1 Neighboring gene synaptonemal complex central element protein 2 Neighboring gene phenylalanyl-tRNA synthetase subunit alpha Neighboring gene calreticulin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Immunolocalization of glutaryl-CoA dehydrogenase (GCDH) in adult and embryonic rat brain and peripheral tissues. Braissant O, et al. Neuroscience, 2017 Feb 20. PMID 27984186
  2. Effects of targeted suppression of glutaryl-CoA dehydrogenase by lentivirus-mediated shRNA and excessive intake of lysine on apoptosis in rat striatal neurons. Gao J, et al. PLoS One, 2013. PMID 23658800, Free PMC Article
  3. Organic aciduria in the riboflavin-deficient rat. Goodman SI. Am J Clin Nutr, 1981 Nov. PMID 6895440
  4. Enzymes of fatty acid beta-oxidation in developing brain. Reichmann H, et al. J Neurochem, 1988 Aug. PMID 2899130
  5. The first knock-in rat model for glutaric aciduria type I allows further insights into pathophysiology in brain and periphery. Gonzalez Melo M, et al. Mol Genet Metab, 2021 Jun. PMID 33965309

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The first knock-in rat model for glutaric aciduria type I allows further insights into pathophysiology in brain and periphery.
    Title: The first knock-in rat model for glutaric aciduria type I allows further insights into pathophysiology in brain and periphery.
  2. GCDH was found widely expressed in embryonic and adult rat tissues. In rat embryos GCDH is predominantly expressed in brain implying an important role for brain development. Interestingly, GCDH was found to be significantly expressed in different other organs (e.g. kidney, gut) in adult rats probably explaining the evolving phenotype in GA-I patients.
    Title: Immunolocalization of glutaryl-CoA dehydrogenase (GCDH) in adult and embryonic rat brain and peripheral tissues.
  3. GA1-induced striatal degeneration is partially caspase-dependent
    Title: Effects of targeted suppression of glutaryl-CoA dehydrogenase by lentivirus-mediated shRNA and excessive intake of lysine on apoptosis in rat striatal neurons.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables fatty-acyl-CoA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fatty-acyl-CoA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutaryl-CoA dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutaryl-CoA dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutaryl-CoA dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in acyl-CoA metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid oxidation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fatty-acyl-CoA biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty-acyl-CoA biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glutaryl-CoA dehydrogenase, mitochondrial
Names
glutaryl-Coenzyme A dehydrogenase
NP_001102366.1
XP_063134240.1
XP_063134241.1
XP_063134242.1
XP_063134243.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108896.1 → NP_001102366.1  glutaryl-CoA dehydrogenase, mitochondrial

    See identical proteins and their annotated locations for NP_001102366.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473972
    UniProtKB/TrEMBL
    A0A8I5ZN89, A6IY64
    Related
    ENSRNOP00000004570.5, ENSRNOT00000004570.6
    Conserved Domains (2) summary
    cd01151
    Location:57 → 443
    GCD; Glutaryl-CoA dehydrogenase
    COG1960
    Location:69 → 443
    CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    40168038..40174536
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063278170.1 → XP_063134240.1  glutaryl-CoA dehydrogenase, mitochondrial isoform X1

  2. XM_063278171.1 → XP_063134241.1  glutaryl-CoA dehydrogenase, mitochondrial isoform X2

  3. XM_063278172.1 → XP_063134242.1  glutaryl-CoA dehydrogenase, mitochondrial isoform X3

  4. XM_063278173.1 → XP_063134243.1  glutaryl-CoA dehydrogenase, mitochondrial isoform X4

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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