RB1 RB transcriptional corepressor 1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: RB1provided by CGNC
Full Name: RB transcriptional corepressor 1provided by CGNC
Primary source: CGNC:12759
See related: Ensembl:ENSGALG00010003900
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	1	NC_052532.1 (168632963..168710104)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	1	NC_052573.1 (168722329..168800163)

Chromosome 1 - NC_052532.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SNP g.32828A>G of RB1 is an obesity-associated variant that directly affects binding with NF-KB and SOX2, leading to changes in RB1 expression which in turn may influence chicken abdominal fat deposition.
Title: Functional Intronic Variant in the Retinoblastoma 1 Gene Underlies Broiler Chicken Adiposity by Altering Nuclear Factor-kB and SRY-Related HMG Box Protein 2 Binding Sites.
Gene expression analysis showed that gRB1 knockdown promoted markers indicating proliferation of Ki-67 (MKi67) expression at 96 h (P < 0.05), and overexpression of gRB1 reduced MKi67 expression at 72 h (P < 0.05).
Title: The retinoblastoma 1 gene (RB1) modulates the proliferation of chicken preadipocytes.
The cell cycle-related gene RB1 showed higher expression in the cultured chicken embryonic fibroblast cells than that of cultured chicken primordial germ cells.
Title: Gene pathways and cell cycle-related genes in cultured avian primordial germ cells.
Experiments showed an essential role of pRb in S-phase entry of the supporting cells in the damaged neonatal chicken utricle and have shown that the proliferation of these cells requires the phosphorylation of pRb
Title: pRb phosphorylation regulates the proliferation of supporting cells in gentamicin-damaged neonatal avian utricle.
the RB1 gene was a major gene for body weight and bone traits
Title: Fine-mapping of quantitative trait loci for body weight and bone traits and positional cloning of the RB1 gene in chicken.

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General gene information

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Markers

P2Y5sts1 (e-PCR), detects polymorphism
- UniSTS:280235

RB1sts1 (e-PCR), detects polymorphism
- UniSTS:280251

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell morphogenesis involved in neuron differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info	PubMed
involved_in neuron projection development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of Rb-E2F complex	IEA Inferred from Electronic Annotation more info	PubMed
part_of chromatin	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: retinoblastoma-associated protein

Names: p104; pRb; rb; retinoblastoma 1 (including osteosarcoma)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204419.2 → NP_989750.2 retinoblastoma-associated protein

Status: PROVISIONAL

Source sequence(s)

JAENSK010000027

UniProtKB/Swiss-Prot

Q788Q6, Q90599, Q90600, Q91016

UniProtKB/TrEMBL

F1NAY3

Related

ENSGALP00010005344.1, ENSGALT00010009040.1

Conserved Domains (1) summary

smart00385
Location:665 → 717

CYCLIN; domain present in cyclins, TFIIB and Retinoblastoma