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GSN gelsolin [ Gallus gallus (chicken) ]

Gene ID: 395774, updated on 3-Apr-2024

Summary

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Official Symbol
GSNprovided by CGNC
Official Full Name
gelsolinprovided by CGNC
Primary source
CGNC:49472
See related
Ensembl:ENSGALG00010027706
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 17
Exon count:
23
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 17 NC_052548.1 (9005170..9031107)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 17 NC_052589.1 (8415857..8441759)

Chromosome 17 - NC_052548.1Genomic Context describing neighboring genes Neighboring gene centriolin Neighboring gene RAB14, member RAS oncogene family Neighboring gene stomatin Neighboring gene DAB2 interacting protein Neighboring gene uncharacterized LOC121107049

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analysis of gelsolin expression pattern in developing chicken embryo reveals high GSN expression level in tissues of neural crest origin. Mazur AJ, et al. Brain Struct Funct, 2016 Jan. PMID 25352156, Free PMC Article
  2. Molecular markers for cell types of the inner ear and candidate genes for hearing disorders. Heller S, et al. Proc Natl Acad Sci U S A, 1998 Sep 15. PMID 9736748, Free PMC Article
  3. Conserved BK channel-protein interactions reveal signals relevant to cell death and survival. Sokolowski B, et al. PLoS One, 2011. PMID 22174833, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GSN is expressed at high levels in some tissues of ectodermal origin including all neural crest derivatives in the developing chick embryo.
    Title: Analysis of gelsolin expression pattern in developing chicken embryo reveals high GSN expression level in tissues of neural crest origin.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament severing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in actin polymerization or depolymerization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in barbed-end actin filament capping IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
gelsolin
Names
ADF
actin-depolymerizing factor
brevin
homogenin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204934.2 → NP_990265.2  gelsolin precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000308
    UniProtKB/Swiss-Prot
    O93510
    Related
    ENSGALP00010041053.1, ENSGALT00010067149.1
    Conserved Domains (6) summary
    cd11288
    Location:557 → 646
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:182 → 271
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:55 → 167
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:662 → 760
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:291 → 391
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:435 → 535
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052548.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    9005170..9031107
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046901664.1 → XP_046757620.1  gelsolin isoform X5

    UniProtKB/TrEMBL
    A0A8V1ACU4

  2. XM_046901659.1 → XP_046757615.1  gelsolin isoform X5

    UniProtKB/TrEMBL
    A0A8V1ACU4

  3. XM_015279330.4 → XP_015134816.2  gelsolin isoform X2

    UniProtKB/TrEMBL
    A0A8V1AA30
    Related
    ENSGALP00010041056.1, ENSGALT00010067152.1
    Conserved Domains (6) summary
    cd11288
    Location:515 → 604
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:140 → 229
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:13 → 125
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:620 → 718
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:249 → 349
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:393 → 493
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  4. XM_046901655.1 → XP_046757611.1  gelsolin isoform X4

  5. XM_015279328.4 → XP_015134814.3  gelsolin isoform X3

    UniProtKB/TrEMBL
    A0A8V1AHE5
    Related
    ENSGALP00010041060.1, ENSGALT00010067156.1

  6. XM_046901660.1 → XP_046757616.1  gelsolin isoform X5

    UniProtKB/TrEMBL
    A0A8V1ACU4

  7. XM_046901661.1 → XP_046757617.1  gelsolin isoform X5

    UniProtKB/TrEMBL
    A0A8V1ACU4

  8. XM_046901657.1 → XP_046757613.1  gelsolin isoform X5

    UniProtKB/TrEMBL
    A0A8V1ACU4

  9. XM_046901662.1 → XP_046757618.1  gelsolin isoform X5

    UniProtKB/TrEMBL
    A0A8V1ACU4

  10. XM_046901656.1 → XP_046757612.1  gelsolin isoform X5

    UniProtKB/TrEMBL
    A0A8V1ACU4

  11. XM_025156026.3 → XP_025011794.2  gelsolin isoform X1

    UniProtKB/TrEMBL
    A0A8V1A570, A0A8V1AA30
    Related
    ENSGALP00010041059.1, ENSGALT00010067155.1
    Conserved Domains (6) summary
    cd11288
    Location:523 → 612
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:148 → 237
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:21 → 133
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:628 → 726
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:257 → 357
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:401 → 501
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  12. XM_046901658.1 → XP_046757614.1  gelsolin isoform X5

    UniProtKB/TrEMBL
    A0A8V1ACU4
    Related
    ENSGALP00010041058.1, ENSGALT00010067154.1

  13. XM_015279329.4 → XP_015134815.2  gelsolin isoform X5

    UniProtKB/TrEMBL
    A0A8V1AA30, A0A8V1ACU4
    Conserved Domains (6) summary
    cd11288
    Location:509 → 598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:134 → 223
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:7 → 119
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:614 → 712
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:243 → 343
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:387 → 487
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  14. XM_046901663.1 → XP_046757619.1  gelsolin isoform X5

    UniProtKB/TrEMBL
    A0A8V1ACU4

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052589.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    8415857..8441759
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046928753.1 → XP_046784709.1  gelsolin isoform X5

  2. XM_046928748.1 → XP_046784704.1  gelsolin isoform X5

  3. XM_046928740.1 → XP_046784696.1  gelsolin isoform X2

  4. XM_046928742.1 → XP_046784698.1  gelsolin isoform X4

  5. XM_046928741.1 → XP_046784697.1  gelsolin isoform X3

  6. XM_046928749.1 → XP_046784705.1  gelsolin isoform X5

  7. XM_046928750.1 → XP_046784706.1  gelsolin isoform X5

  8. XM_046928746.1 → XP_046784702.1  gelsolin isoform X5

  9. XM_046928751.1 → XP_046784707.1  gelsolin isoform X5

  10. XM_046928744.1 → XP_046784700.1  gelsolin isoform X5

  11. XM_046928739.1 → XP_046784695.1  gelsolin isoform X1

  12. XM_046928747.1 → XP_046784703.1  gelsolin isoform X5

  13. XM_046928743.1 → XP_046784699.1  gelsolin isoform X5

  14. XM_046928752.1 → XP_046784708.1  gelsolin isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O93510.1 GenPept UniProtKB/Swiss-Prot:O93510

Gene LinkOut

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