ticam1 TIR domain containing adaptor molecule 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ticam1provided by ZNC
Official Full Name: TIR domain containing adaptor molecule 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040219-2
See related: Ensembl:ENSDARG00000102493 AllianceGenome:ZFIN:ZDB-GENE-040219-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: trif
Summary: Predicted to enable protein kinase binding activity. Acts upstream of or within positive regulation of I-kappaB kinase/NF-kappaB signaling and positive regulation of interferon-beta production. Located in Golgi apparatus. Is expressed in several structures, including eye; heart; integument; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human TICAM1 (toll like receptor adaptor molecule 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 22

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (4442473..4445833)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (3989625..3992985)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

3D-models of rohu TLR3-TIR and zebrafish TRIF
Title: Structural insights of rohu TLR3, its binding site analysis with fish reovirus dsRNA, poly I:C and zebrafish TRIF.
study focuses on the functional characterization of zebrafish TRIF; results show that the full length cDNA of zebrafish TRIF encodes a protein of 556 amino acids; TRIF is able to induce the IFN promoter as well as activate NF-kappaB response promoter
Title: Zebrafish TRIF, a Golgi-localized protein, participates in IFN induction and NF-kappaB activation.
The role of zebrafish (Danio rerio) TICAM1 in activating NF-kappaB and zebrafish type I IFN was described.
Title: Evidence for evolving Toll-IL-1 receptor-containing adaptor molecule function in vertebrates.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in TRIF-dependent toll-like receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within TRIF-dependent toll-like receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of interferon-beta production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of type I interferon production	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: TIR domain-containing adapter molecule 1

Names: TIR domain containing adaptor inducing interferon-beta; TIR-domain containing adaptor inducing IFN-beta; TRIF/TICAM1; toll-like receptor adaptor molecule 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.