KITLG KIT ligand [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: KITLGprovided by VGNC
Official Full Name: KIT ligandprovided by VGNC
Primary source: VGNC:VGNC:42423
See related: Ensembl:ENSCAFG00845018506
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: CSF; MGF; 710-712
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	15	NC_051819.1 (30230533..30311189, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	15	NC_006597.4 (30041648..30122153, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	15	NC_049236.1 (29890288..29970909, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	15	NC_049275.1 (29545261..29626200, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	15	NC_049756.1 (29607389..29688442, complement)

Chromosome 15 - NC_051819.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A point mutation in the extracellular domain of KIT promotes tumorigenesis of mast cells via ligand-independent auto-dimerization
Title: A point mutation in the extracellular domain of KIT promotes tumorigenesis of mast cells via ligand-independent auto-dimerization.
The relationship between KIT gene expression and tumor recurrence and mortality in dogs with cutaneous mast cell tumors was investigated via RT-PCR and immunohistochemistry.
Title: The value of molecular expression of KIT and KIT ligand analysed using real-time polymerase chain reaction and immunohistochemistry as a prognostic indicator for canine cutaneous mast cell tumours.
Our findings highlight a role for KITLG in SCCD susceptibility, as well as demonstrate that interactions between the KITLG and MC1R loci are potentially required for SCCD oncogenesis
Title: A copy number variant at the KITLG locus likely confers risk for canine squamous cell carcinoma of the digit.
The aim of this work was to evaluate whether canine stem cell factor (cSCF) contributes to matrix metalloproteinase (MMP)-9 secretion by CD34 cells.
Title: Canine stem cell factor augments expression of matrix metalloproteinase-9 by CD34 cells.
Dysregulation of Kit/SCF, Flt3/Flt3L, and Met/HGF signaling pathways is unlikely to occur in histiocytic sarcomas of dogs.
Title: Evaluation of dysregulation of the receptor tyrosine kinases Kit, Flt3, and Met in histiocytic sarcomas of dogs.

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General gene information

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Markers

Kitl (e-PCR), detects polymorphism
- UniSTS:261909

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info	PubMed
enables stem cell factor receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: kit ligand

Names: SCF; c-kit ligand; mast cell growth factor; stem cell factor, CSF

NP_001012753.1

EC 3.2.1.31

XP_038543093.1

EC 3.2.1.31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.