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PAX8 paired box 8 [ Canis lupus familiaris (dog) ]

Gene ID: 403927, updated on 5-Mar-2024

Summary

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Official Symbol
PAX8provided by VGNC
Official Full Name
paired box 8provided by VGNC
Primary source
VGNC:VGNC:44279
See related
Ensembl:ENSCAFG00845012268
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
PAX-8
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 17
Exon count:
14
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 17 NC_051821.1 (38084443..38141710, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 17 NC_006599.4 (37077650..37133660, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 17 NC_049238.1 (37490112..37546218, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 17 NC_049277.1 (37220866..37276852, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 17 NC_049758.1 (37277373..37333166, complement)

Chromosome 17 - NC_051821.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119869695 Neighboring gene interleukin 1 receptor antagonist Neighboring gene pleckstrin and Sec7 domain containing 4 Neighboring gene small nucleolar RNA SNORA72 Neighboring gene uncharacterized LOC102152844

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pax8, Napsin A, and CD10 as Immunohistochemical Markers of Canine Renal Cell Carcinoma. Peat TJ, et al. Vet Pathol, 2017 Jul. PMID 28346124
  2. Pax 8 expression in primary cultured dog thyrocyte is increased by cyclic AMP. Van Renterghem P, et al. Biochim Biophys Acta, 1996 Jun 3. PMID 8652674

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. utility as an immunohistochemical marker in diagnosing all major subtypes of primary and metastatic renal cell carcinoma
    Title: Pax8, Napsin A, and CD10 as Immunohistochemical Markers of Canine Renal Cell Carcinoma.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in anatomical structure development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
paired box protein Pax-8
Names
paired box gene 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001389220.1 → NP_001376149.1  paired box protein Pax-8

    Status: VALIDATED

    Source sequence(s)
    DN351611, DN443735, X83591
    UniProtKB/Swiss-Prot
    P47240, P47241
    UniProtKB/TrEMBL
    A0A8C0KWP6, A0A8I3NMV8, A0A8P0N9N0
    Related
    ENSCAFP00845017204.1, ENSCAFT00845021871.1
    Conserved Domains (2) summary
    smart00351
    Location:9 → 133
    PAX; Paired Box domain
    pfam12403
    Location:346 → 457
    Pax2_C; Paired-box protein 2 C terminal

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051821.1 Reference ROS_Cfam_1.0

    Range
    38084443..38141710 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038690447.1 → XP_038546375.1  paired box protein Pax-8 isoform X8

    UniProtKB/TrEMBL
    A0A8I3NMV8, A0A8P0N9N0
    Conserved Domains (2) summary
    smart00351
    Location:9 → 133
    PAX; Paired Box domain
    pfam12403
    Location:350 → 461
    Pax2_C; Paired-box protein 2 C terminal

  2. XM_038690445.1 → XP_038546373.1  paired box protein Pax-8 isoform X7

    UniProtKB/TrEMBL
    A0A8I3NMV8, A0A8P0N9N0
    Conserved Domains (2) summary
    smart00351
    Location:9 → 134
    PAX; Paired Box domain
    pfam12403
    Location:351 → 462
    Pax2_C; Paired-box protein 2 C terminal

  3. XM_038690446.1 → XP_038546374.1  paired box protein Pax-8 isoform X7

    UniProtKB/TrEMBL
    A0A8I3NMV8, A0A8P0N9N0
    Conserved Domains (2) summary
    smart00351
    Location:9 → 134
    PAX; Paired Box domain
    pfam12403
    Location:351 → 462
    Pax2_C; Paired-box protein 2 C terminal

  4. XM_038690448.1 → XP_038546376.1  paired box protein Pax-8 isoform X9

    UniProtKB/TrEMBL
    A0A8C0SJZ8
    Conserved Domains (1) summary
    smart00351
    Location:31 → 156
    PAX; Paired Box domain

  5. XM_038690454.1 → XP_038546382.1  paired box protein Pax-8 isoform X15

    Conserved Domains (2) summary
    smart00351
    Location:31 → 156
    PAX; Paired Box domain
    pfam12403
    Location:305 → 414
    Pax2_C; Paired-box protein 2 C terminal

  6. XM_038690439.1 → XP_038546367.1  paired box protein Pax-8 isoform X1

    UniProtKB/TrEMBL
    A0A8I3NMV8, A0A8P0N9N0
    Conserved Domains (2) summary
    smart00351
    Location:31 → 156
    PAX; Paired Box domain
    pfam12403
    Location:373 → 484
    Pax2_C; Paired-box protein 2 C terminal

  7. XM_038690451.1 → XP_038546379.1  paired box protein Pax-8 isoform X12

    UniProtKB/TrEMBL
    A0A8C0SJZ8
    Conserved Domains (2) summary
    smart00351
    Location:31 → 156
    PAX; Paired Box domain
    PHA03247
    Location:173 → 391
    PHA03247; large tegument protein UL36; Provisional

  8. XM_038690457.1 → XP_038546385.1  paired box protein Pax-8 isoform X18

    Conserved Domains (2) summary
    smart00351
    Location:31 → 156
    PAX; Paired Box domain
    pfam12403
    Location:305 → 385
    Pax2_C; Paired-box protein 2 C terminal

  9. XM_038690456.1 → XP_038546384.1  paired box protein Pax-8 isoform X17

    Conserved Domains (2) summary
    smart00351
    Location:31 → 156
    PAX; Paired Box domain
    pfam12403
    Location:305 → 363
    Pax2_C; Paired-box protein 2 C terminal

  10. XM_038690444.1 → XP_038546372.1  paired box protein Pax-8 isoform X6

    UniProtKB/TrEMBL
    A0A8C0SJZ8
    Conserved Domains (2) summary
    smart00351
    Location:31 → 156
    PAX; Paired Box domain
    PHA03247
    Location:173 → 391
    PHA03247; large tegument protein UL36; Provisional

  11. XM_038690450.1 → XP_038546378.1  paired box protein Pax-8 isoform X11

    UniProtKB/TrEMBL
    A0A8I3NMV8, A0A8P0N9N0
    Conserved Domains (2) summary
    smart00351
    Location:31 → 156
    PAX; Paired Box domain
    pfam12403
    Location:373 → 455
    Pax2_C; Paired-box protein 2 C terminal

  12. XM_038690443.1 → XP_038546371.1  paired box protein Pax-8 isoform X5

    UniProtKB/TrEMBL
    A0A8I3NMV8, A0A8P0N9N0
    Conserved Domains (2) summary
    smart00351
    Location:31 → 156
    PAX; Paired Box domain
    pfam12403
    Location:373 → 433
    Pax2_C; Paired-box protein 2 C terminal

  13. XM_038690458.1 → XP_038546386.1  paired box protein Pax-8 isoform X19

    Conserved Domains (1) summary
    smart00351
    Location:31 → 156
    PAX; Paired Box domain

  14. XM_038690453.1 → XP_038546381.1  paired box protein Pax-8 isoform X14

    UniProtKB/TrEMBL
    A0A8C0SJZ8
    Conserved Domains (2) summary
    smart00351
    Location:31 → 156
    PAX; Paired Box domain
    PHA03247
    Location:173 → 391
    PHA03247; large tegument protein UL36; Provisional

  15. XM_038690452.1 → XP_038546380.1  paired box protein Pax-8 isoform X13

    UniProtKB/TrEMBL
    A0A8C0SJZ8
    Conserved Domains (1) summary
    smart00351
    Location:31 → 155
    PAX; Paired Box domain

  16. XM_038690449.1 → XP_038546377.1  paired box protein Pax-8 isoform X10

    UniProtKB/TrEMBL
    A0A8C0SJZ8
    Conserved Domains (1) summary
    smart00351
    Location:31 → 155
    PAX; Paired Box domain

  17. XM_038690440.1 → XP_038546368.1  paired box protein Pax-8 isoform X2

    UniProtKB/TrEMBL
    A0A8I3NMV8, A0A8P0N9N0
    Conserved Domains (2) summary
    smart00351
    Location:31 → 155
    PAX; Paired Box domain
    pfam12403
    Location:372 → 483
    Pax2_C; Paired-box protein 2 C terminal

  18. XM_038690441.1 → XP_038546369.1  paired box protein Pax-8 isoform X3

    UniProtKB/TrEMBL
    A0A8I3NMV8, A0A8P0N9N0
    Conserved Domains (2) summary
    smart00351
    Location:31 → 156
    PAX; Paired Box domain
    pfam12403
    Location:369 → 480
    Pax2_C; Paired-box protein 2 C terminal

  19. XM_038690460.1 → XP_038546388.1  paired box protein Pax-8 isoform X21

    Conserved Domains (2) summary
    smart00351
    Location:31 → 155
    PAX; Paired Box domain
    pfam12403
    Location:304 → 413
    Pax2_C; Paired-box protein 2 C terminal

  20. XM_038690455.1 → XP_038546383.1  paired box protein Pax-8 isoform X16

    Conserved Domains (2) summary
    smart00351
    Location:31 → 156
    PAX; Paired Box domain
    pfam12403
    Location:301 → 410
    Pax2_C; Paired-box protein 2 C terminal

  21. XM_038690459.1 → XP_038546387.1  paired box protein Pax-8 isoform X20

    UniProtKB/TrEMBL
    A0A8C0YXY5, A0A8I3NL25
    Related
    ENSCAFP00845017288.1, ENSCAFT00845021992.1
    Conserved Domains (1) summary
    smart00351
    Location:31 → 155
    PAX; Paired Box domain

  22. XM_038690442.1 → XP_038546370.1  paired box protein Pax-8 isoform X4

    UniProtKB/TrEMBL
    A0A8I3NGE6, A0A8I3NMV8, A0A8P0N9N0, A0A8P0P1T1
    Related
    ENSCAFP00845017254.1, ENSCAFT00845021942.1
    Conserved Domains (2) summary
    smart00351
    Location:31 → 155
    PAX; Paired Box domain
    pfam12403
    Location:368 → 479
    Pax2_C; Paired-box protein 2 C terminal

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049277.1 Alternate UMICH_Zoey_3.1

    Range
    37220866..37276852 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049758.1 Alternate UNSW_CanFamBas_1.0

    Range
    37277373..37333166 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049238.1 Alternate UU_Cfam_GSD_1.0

    Range
    37490112..37546218 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006599.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    37077650..37133660 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001003248.1: Suppressed sequence

    Description
    NM_001003248.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47240.1 GenPept UniProtKB/Swiss-Prot:P47240

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