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LOC403934 cell division cycle 42 [ Canis lupus familiaris (dog) ]

Gene ID: 403934, updated on 25-Jan-2024

Summary

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Gene symbol
LOC403934
Gene description
cell division cycle 42
See related
Ensembl:ENSCAFG00845003209
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
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Genomic context

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See LOC403934 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
1
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 4 NC_051808.1 (4445564..4446293)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 4 NC_049225.1 (4796130..4796859)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 4 NC_049264.1 (4457005..4457734)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 4 NC_049745.1 (4574515..4575244)

Chromosome 4 - NC_051808.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119871604 Neighboring gene G protein subunit gamma 4 Neighboring gene cell division control protein 42 pseudogene Neighboring gene beta-1,3-N-acetylgalactosaminyltransferase 2 Neighboring gene tubulin folding cofactor E Neighboring gene non-POU domain-containing octamer-binding protein-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The small GTPase Cdc42 regulates actin polymerization and tension development during contractile stimulation of smooth muscle. Tang DD, et al. J Biol Chem, 2004 Dec 10. PMID 15456777
  2. Regulation of anoikis by Cdc42 and Rac1. Cheng TL, et al. Exp Cell Res, 2004 May 1. PMID 15093747
  3. Early herpes simplex virus type 1 infection is dependent on regulated Rac1/Cdc42 signalling in epithelial MDCKII cells. Hoppe S, et al. J Gen Virol, 2006 Dec. PMID 17098962
  4. Rab14 specifies the apical membrane through Arf6-mediated regulation of lipid domains and Cdc42. Lu R, et al. Sci Rep, 2016 Nov 30. PMID 27901125, Free PMC Article
  5. Zonula occludens-2 regulates Rho proteins activity and the development of epithelial cytoarchitecture and barrier function. Raya-Sandino A, et al. Biochim Biophys Acta Mol Cell Res, 2017 Oct. PMID 28554775

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rab14 knockdown results in increased Cdc42 activity mediated through Arf6.
    Title: Rab14 specifies the apical membrane through Arf6-mediated regulation of lipid domains and Cdc42.
  2. Silencing tight junction protein ZO-2 alters epithelial cytoarchitecture.ZO-2 silencing increases RhoA activity through GEF-H1 recruitment to cell borders.ZO-2 silencing activates Cdc42 and triggers mitotic spindle disorientation. ZO-2 silencing increases Rac1 and cofilin activity and lamellipodia formation.
    Title: Zonula occludens-2 regulates Rho proteins activity and the development of epithelial cytoarchitecture and barrier function.
  3. Cdc42 activation regulates active tension development and actin polymerization during smooth muscle contractile stimulation
    Title: The small GTPase Cdc42 regulates actin polymerization and tension development during contractile stimulation of smooth muscle.
  4. CDC42 regulates anoikis.
    Title: Regulation of anoikis by Cdc42 and Rac1.
  5. these results provide the first evidence for a role of Rac1/Cdc42 signalling during early HSV-1 infection and suggest a mechanism relying on virus-induced regulation of Rac1/Cdc42 activities.
    Title: Early herpes simplex virus type 1 infection is dependent on regulated Rac1/Cdc42 signalling in epithelial MDCKII cells.
  6. CrkII plays a critical role in the regulation of N-WASp activation, actin polymerization, and active tension generation in tracheal smooth muscle, by regulating the activation of cdc42 [CrkII]
    Title: The adapter protein CrkII regulates neuronal Wiskott-Aldrich syndrome protein, actin polymerization, and tension development during contractile stimulation of smooth muscle.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in modification of synaptic structure IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cell division control protein 42 homolog
Names
CDC42 GTP-binding protein
G25K GTP-binding protein
cell division cycle 42 (GTP binding protein, 25kDa)
NP_001376150.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001389221.1 → NP_001376150.1  cell division control protein 42 homolog

    Status: VALIDATED

    Source sequence(s)
    DN353664, DN371418
    UniProtKB/Swiss-Prot
    P60952
    UniProtKB/TrEMBL
    A0A8C0NDL5, A0A8I3P5T9
    Related
    ENSCAFP00845004474.1, ENSCAFT00845005638.1
    Conserved Domains (1) summary
    cd01874
    Location:3 → 177
    Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051808.1 Reference ROS_Cfam_1.0

    Range
    4445564..4446293
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049264.1 Alternate UMICH_Zoey_3.1

    Range
    4457005..4457734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049745.1 Alternate UNSW_CanFamBas_1.0

    Range
    4574515..4575244
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049225.1 Alternate UU_Cfam_GSD_1.0

    Range
    4796130..4796859
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001003254.2: Suppressed sequence

    Description
    NM_001003254.2: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein
Heading Accession and Version

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