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cdc20 cell division cycle 20 homolog [ Danio rerio (zebrafish) ]

Gene ID: 406353, updated on 27-Mar-2024

Summary

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Official Symbol
cdc20provided by ZNC
Official Full Name
cell division cycle 20 homologprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2044
See related
Ensembl:ENSDARG00000100741 AllianceGenome:ZFIN:ZDB-GENE-040426-2044
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zom; zombie; zgc:63536; wu:fe49f10
Summary
Predicted to enable anaphase-promoting complex binding activity and ubiquitin ligase activator activity. Predicted to be involved in anaphase-promoting complex-dependent catabolic process and positive regulation of anaphase-promoting complex-dependent catabolic process. Predicted to act upstream of or within cell division and positive regulation of ubiquitin protein ligase activity. Predicted to be part of anaphase-promoting complex. Is expressed in proliferative region. Orthologous to human CDC20 (cell division cycle 20). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (19217584..19234369, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (19568521..19585305, complement)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene si:dkey-225f23.4 Neighboring gene kinocilin Neighboring gene ELOVL fatty acid elongase 1a Neighboring gene coiled-coil and C2 domain containing 1B Neighboring gene zinc finger, FYVE domain containing 9a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The zebrafish epiboly mutants. Kane DA, et al. Development, 1996 Dec. PMID 9007228
  2. Bisexual Fertile Triploid Zebrafish (Danio rerio): a Rare Case. Peng L, et al. Mar Biotechnol (NY), 2020 Jun. PMID 32307628
  3. DHX33 Transcriptionally Controls Genes Involved in the Cell Cycle. Yuan B, et al. Mol Cell Biol, 2016 Dec 1. PMID 27601587, Free PMC Article
  4. c-myb hyperactivity leads to myeloid and lymphoid malignancies in zebrafish. Liu W, et al. Leukemia, 2017 Jan. PMID 27457538, Free PMC Article
  5. Progressive loss of RacGAP1/ogre activity has sequential effects on cytokinesis and zebrafish development. Warga RM, et al. Dev Biol, 2016 Oct 15. PMID 27339293

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables anaphase-promoting complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables anaphase-promoting complex binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin ligase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cell division cycle protein 20 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213080.2 → NP_998245.2  cell division cycle protein 20 homolog

    See identical proteins and their annotated locations for NP_998245.2

    Status: VALIDATED

    Source sequence(s)
    BX323588
    UniProtKB/TrEMBL
    A0A0R4IU39, A0A8M3AX75
    Related
    ENSDARP00000140575.1, ENSDART00000160060.2
    Conserved Domains (3) summary
    COG2319
    Location:194 → 484
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:196 → 471
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:230 → 267
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    19217584..19234369 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009298475.3 → XP_009296750.1  cell division cycle protein 20 homolog isoform X1

    See identical proteins and their annotated locations for XP_009296750.1

    UniProtKB/TrEMBL
    A0A0R4IU39, A0A8M3AX75
    Conserved Domains (3) summary
    COG2319
    Location:194 → 484
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:196 → 471
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:230 → 267
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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