U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

pabpn1 poly(A) binding protein, nuclear 1 [ Danio rerio (zebrafish) ]

Gene ID: 406543, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
pabpn1provided by ZNC
Official Full Name
poly(A) binding protein, nuclear 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2401
See related
Ensembl:ENSDARG00000045373 AllianceGenome:ZFIN:ZDB-GENE-040426-2401
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb19c03; zgc:85979; zgc:92452; wu:fb17e03; wu:fb18c06; wu:fb19c03
Summary
Predicted to enable RNA binding activity. Human ortholog(s) of this gene implicated in oculopharyngeal muscular dystrophy. Orthologous to human PABPN1 (poly(A) binding protein nuclear 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 24
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (14559334..14577559, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (14414915..14433140, complement)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene putative nuclease HARBI1 Neighboring gene neuroguidin, EIF4E binding protein Neighboring gene zinc finger homeobox 2 Neighboring gene thiamine triphosphatase

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Zebrafish orthologs of human muscular dystrophy genes. Steffen LS, et al. BMC Genomics, 2007 Mar 20. PMID 17374169, Free PMC Article
  2. Dynamic RNA-protein interactions underlie the zebrafish maternal-to-zygotic transition. Despic V, et al. Genome Res, 2017 Jul. PMID 28381614, Free PMC Article
  3. Global identification of SMAD2 target genes reveals a role for multiple co-regulatory factors in zebrafish early gastrulas. Liu Z, et al. J Biol Chem, 2011 Aug 12. PMID 21669877, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC92452, MGC171884, MGC173800

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(A) binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
polyadenylate-binding protein 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105132.2 → NP_001098602.1  polyadenylate-binding protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001098602.1

    Status: VALIDATED

    Source sequence(s)
    BC079522, BX294113, EH513490
    UniProtKB/TrEMBL
    A7YYD9, A8KBA1, F6PFP9
    Related
    ENSDARP00000100125.2, ENSDART00000109088.4
    Conserved Domains (2) summary
    PLN03134
    Location:74 → 209
    PLN03134; glycine-rich RNA-binding protein 4; Provisional
    cd12550
    Location:99 → 174
    RRM_II_PABPN1; RNA recognition motif in type II polyadenylate-binding protein 2 (PABP-2) and similar proteins

  2. NM_213259.2 → NP_998424.1  polyadenylate-binding protein 2 isoform 1

    See identical proteins and their annotated locations for NP_998424.1

    Status: VALIDATED

    Source sequence(s)
    BC079522, BX294113, EH513490
    UniProtKB/TrEMBL
    B2GQ88, F6P4W0, Q6NUT4
    Related
    ENSDARP00000066721.6, ENSDART00000066722.8
    Conserved Domains (2) summary
    PLN03134
    Location:74 → 209
    PLN03134; glycine-rich RNA-binding protein 4; Provisional
    cd12550
    Location:99 → 174
    RRM_II_PABPN1; RNA recognition motif in type II polyadenylate-binding protein 2 (PABP-2) and similar proteins

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    14559334..14577559 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005162637.3 → XP_005162694.1  polyadenylate-binding protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B9U2
    Related
    ENSDARP00000124946.1, ENSDART00000140624.3
    Conserved Domains (2) summary
    PLN03134
    Location:18 → 153
    PLN03134; glycine-rich RNA-binding protein 4; Provisional
    cd12550
    Location:43 → 118
    RRM_II_PABPN1; RNA recognition motif in type II polyadenylate-binding protein 2 (PABP-2) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous