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terf2ip telomeric repeat binding factor 2, interacting protein [ Danio rerio (zebrafish) ]

Gene ID: 407707, updated on 11-Apr-2024

Summary

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Official Symbol
terf2ipprovided by ZNC
Official Full Name
telomeric repeat binding factor 2, interacting proteinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-131121-641
See related
Ensembl:ENSDARG00000103977 AllianceGenome:ZFIN:ZDB-GENE-131121-641
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
RAP1
Summary
Predicted to enable telomeric DNA binding activity. Predicted to be involved in positive regulation of I-kappaB kinase/NF-kappaB signaling; regulation of nucleobase-containing compound metabolic process; and telomere maintenance via telomere lengthening. Predicted to act upstream of or within telomere maintenance. Predicted to be located in chromosome, telomeric region; cytoplasm; and nucleus. Predicted to be part of shelterin complex. Is expressed in several structures, including gill; heart; liver; pleuroperitoneal region; and post-vent region. Orthologous to human TERF2IP (TERF2 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 22
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (34598805..34614210, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (34623898..34639299, complement)

Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene glutamate metabotropic receptor 7 Neighboring gene ring finger protein 123 Neighboring gene si:ch1073-214b20.2 Neighboring gene adhesion molecule with Ig-like domain 3 Neighboring gene si:ch73-304f21.1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The knockdown efficiency of telomere associated genes with specific methodology in a zebrafish cell line. Hu X, et al. Biochimie, 2021 Nov. PMID 34214617
  2. The differential spatiotemporal expression pattern of shelterin genes throughout lifespan. Wagner KD, et al. Aging (Albany NY), 2017 Apr. PMID 28437249, Free PMC Article
  3. Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Giffen KP, et al. Front Neurosci, 2019. PMID 31680844, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protection from non-homologous end joining at telomere IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within telomere maintenance IEA
Inferred from Electronic Annotation
more info
  
involved_in telomere maintenance via telomere lengthening IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in telomere maintenance via telomere lengthening IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of shelterin complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
telomeric repeat-binding factor 2-interacting protein 1
Names
RAP1 homolog
TERF2-interacting telomeric protein 1
TRF2-interacting telomeric protein 1
repressor/activator protein 1 homolog
zmp:0000000584

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001202416.1 → NP_001189345.1  telomeric repeat-binding factor 2-interacting protein 1

    See identical proteins and their annotated locations for NP_001189345.1

    Status: VALIDATED

    Source sequence(s)
    CABZ01048351, CU481774
    UniProtKB/Swiss-Prot
    Q5BKV6, Q6NYJ3
    UniProtKB/TrEMBL
    A0A0R4IRZ2, A0A8M1P1Q7
    Related
    ENSDARP00000131029.1, ENSDART00000158690.2
    Conserved Domains (3) summary
    cd11653
    Location:519 → 613
    rap1_RCT; C-terminal domain of RAP1 recruits proteins to telomeres
    pfam08914
    Location:116 → 177
    Myb_DNA-bind_2; Rap1 Myb domain
    pfam16589
    Location:11 → 97
    BRCT_2; BRCT domain, a BRCA1 C-terminus domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007133.7 Reference GRCz11 Primary Assembly

    Range
    34598805..34614210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009296493.3 → XP_009294768.2  telomeric repeat-binding factor 2-interacting protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5BKV6, Q6NYJ3
    UniProtKB/TrEMBL
    A0A8M3B5S4

  2. XM_009296495.2 → XP_009294770.1  telomeric repeat-binding factor 2-interacting protein 1 isoform X2

    See identical proteins and their annotated locations for XP_009294770.1

    UniProtKB/Swiss-Prot
    Q5BKV6, Q6NYJ3
    UniProtKB/TrEMBL
    A0A0R4IRZ2, A0A8M1P1Q7
    Related
    ENSDARP00000139292.1, ENSDART00000171712.2
    Conserved Domains (3) summary
    cd11653
    Location:519 → 613
    rap1_RCT; C-terminal domain of RAP1 recruits proteins to telomeres
    pfam08914
    Location:116 → 177
    Myb_DNA-bind_2; Rap1 Myb domain
    pfam16589
    Location:11 → 97
    BRCT_2; BRCT domain, a BRCA1 C-terminus domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NYJ3.2 GenPept UniProtKB/Swiss-Prot:Q6NYJ3

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