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APC APC, WNT signaling pathway regulator [ Gallus gallus (chicken) ]

Gene ID: 415607, updated on 3-Apr-2024

Summary

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Symbol
APCprovided by CGNC
Full Name
APC, WNT signaling pathway regulatorprovided by CGNC
Primary source
CGNC:50025
See related
Ensembl:ENSGALG00010008333
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
APC1; CTC-554D6.1
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Z
Exon count:
20
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) Z NC_052572.1 (46692041..46785098, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) Z NC_059536.1 (46692041..46785098, complement)

Chromosome Z - NC_052572.1Genomic Context describing neighboring genes Neighboring gene receptor accessory protein 5 Neighboring gene signal recognition particle 19 Neighboring gene erythrocyte membrane protein band 4.1 like 4A Neighboring gene uncharacterized LOC107052340 Neighboring gene small nucleolar RNA SNORA13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Adenomatous polyposis coli is differentially distributed in growth cones and modulates their steering. Koester MP, et al. J Neurosci, 2007 Nov 14. PMID 18003838, Free PMC Article
  2. Tumorigenic fragments of APC cause dominant defects in directional cell migration in multiple model systems. Nelson SA, et al. Dis Model Mech, 2012 Nov. PMID 22563063, Free PMC Article
  3. The postsynaptic adenomatous polyposis coli (APC) multiprotein complex is required for localizing neuroligin and neurexin to neuronal nicotinic synapses in vivo. Rosenberg MM, et al. J Neurosci, 2010 Aug 18. PMID 20720115, Free PMC Article
  4. Adenomatous polyposis coli plays a key role, in vivo, in coordinating assembly of the neuronal nicotinic postsynaptic complex. Rosenberg MM, et al. Mol Cell Neurosci, 2008 Jun. PMID 18407517, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminal fragments of APC represent a gain-of-function mutation that causes cells within tissue to fail to migrate directionally.
    Title: Tumorigenic fragments of APC cause dominant defects in directional cell migration in multiple model systems.
  2. Study defines a novel neural role for APC by showing that the postsynaptic APC multiprotein complex is required for anchoring neuroligin and neurexin at neuronal synapses in vivo.
    Title: The postsynaptic adenomatous polyposis coli (APC) multiprotein complex is required for localizing neuroligin and neurexin to neuronal nicotinic synapses in vivo.
  3. new role for APC as an in vivo coordinator of nicotinic postsynaptic assembly in vertebrate neurons
    Title: Adenomatous polyposis coli plays a key role, in vivo, in coordinating assembly of the neuronal nicotinic postsynaptic complex.
  4. Our data thus demonstrate a crucial role of APC for axon steering attributable to its multifunctional domain structure and differential distribution in the growth cone.
    Title: Adenomatous polyposis coli is differentially distributed in growth cones and modulates their steering.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables beta-catenin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables gamma-catenin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell fate specification IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of microtubule depolymerization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in pattern specification process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of beta-catenin destruction complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of catenin complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasmic microtubule IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
adenomatous polyposis coli protein
Names
adenomatosis polyposis coli
adenomatous polyposis coli 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052572.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    46692041..46785098 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046905989.1 → XP_046761945.1  adenomatous polyposis coli protein isoform X10

    Related
    ENSGALP00010011482.1, ENSGALT00010019934.1

  2. XM_040655703.2 → XP_040511637.1  adenomatous polyposis coli protein isoform X3

    UniProtKB/TrEMBL
    A0A8V0XZP1
    Conserved Domains (5) summary
    pfam05483
    Location:5 → 262
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00185
    Location:690 → 730
    ARM; Armadillo/beta-catenin-like repeats
    PHA03247
    Location:2289 → 2602
    PHA03247; large tegument protein UL36; Provisional
    sd00043
    Location:506 → 549
    ARM; armadillo repeat [structural motif]
    pfam16689
    Location:4 → 55
    APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain

  3. XM_046905988.1 → XP_046761944.1  adenomatous polyposis coli protein isoform X7

    UniProtKB/TrEMBL
    A0A1D5PC88
    Related
    ENSGALP00010011489.1, ENSGALT00010019940.1

  4. XM_046905986.1 → XP_046761942.1  adenomatous polyposis coli protein isoform X5

  5. XM_046905985.1 → XP_046761941.1  adenomatous polyposis coli protein isoform X2

  6. XM_046905987.1 → XP_046761943.1  adenomatous polyposis coli protein isoform X6

  7. XM_046905990.1 → XP_046761946.1  adenomatous polyposis coli protein isoform X12

  8. XM_040655700.2 → XP_040511634.1  adenomatous polyposis coli protein isoform X1

    UniProtKB/TrEMBL
    A0A8V0Y267
    Conserved Domains (4) summary
    smart00185
    Location:702 → 742
    ARM; Armadillo/beta-catenin-like repeats
    PHA03247
    Location:2301 → 2614
    PHA03247; large tegument protein UL36; Provisional
    sd00043
    Location:518 → 561
    ARM; armadillo repeat [structural motif]
    pfam16689
    Location:4 → 67
    APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain

  9. XM_040655705.2 → XP_040511639.1  adenomatous polyposis coli protein isoform X3

    UniProtKB/TrEMBL
    A0A8V0XZP1
    Conserved Domains (5) summary
    pfam05483
    Location:5 → 262
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00185
    Location:690 → 730
    ARM; Armadillo/beta-catenin-like repeats
    PHA03247
    Location:2289 → 2602
    PHA03247; large tegument protein UL36; Provisional
    sd00043
    Location:506 → 549
    ARM; armadillo repeat [structural motif]
    pfam16689
    Location:4 → 55
    APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain

  10. XM_040655699.2 → XP_040511633.1  adenomatous polyposis coli protein isoform X1

    UniProtKB/TrEMBL
    A0A8V0Y267
    Conserved Domains (4) summary
    smart00185
    Location:702 → 742
    ARM; Armadillo/beta-catenin-like repeats
    PHA03247
    Location:2301 → 2614
    PHA03247; large tegument protein UL36; Provisional
    sd00043
    Location:518 → 561
    ARM; armadillo repeat [structural motif]
    pfam16689
    Location:4 → 67
    APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain

  11. XM_040655710.2 → XP_040511644.1  adenomatous polyposis coli protein isoform X10

    UniProtKB/TrEMBL
    A0A8V0XZP1
    Related
    ENSGALP00010011495.1, ENSGALT00010019947.1
    Conserved Domains (16) summary
    smart00185
    Location:649 → 689
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:465 → 508
    ARM; armadillo repeat [structural motif]
    pfam16689
    Location:4 → 55
    APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
    pfam00514
    Location:691 → 731
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:1642 → 1665
    APC_r; APC repeat
    pfam05924
    Location:2030 → 2049
    SAMP; SAMP Motif
    pfam05937
    Location:2668 → 2841
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2220 → 2565
    APC_basic; APC basic domain
    pfam11414
    Location:127 → 207
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:732 → 1022
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:1039 → 1138
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1287 → 1373
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1667 → 1720
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1751 → 1842
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1876 → 1943
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:393 → 466
    APC_rep; Adenomatous polyposis coli (APC) repeat

  12. XM_040655708.2 → XP_040511642.1  adenomatous polyposis coli protein isoform X8

    UniProtKB/TrEMBL
    A0A8V0XZP1, A0A8V0Y647
    Related
    ENSGALP00010011500.1, ENSGALT00010019952.1
    Conserved Domains (16) summary
    smart00185
    Location:657 → 697
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:473 → 516
    ARM; armadillo repeat [structural motif]
    pfam16689
    Location:4 → 55
    APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
    pfam00514
    Location:699 → 739
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:1650 → 1673
    APC_r; APC repeat
    pfam05924
    Location:2038 → 2057
    SAMP; SAMP Motif
    pfam05937
    Location:2676 → 2849
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2228 → 2573
    APC_basic; APC basic domain
    pfam11414
    Location:127 → 207
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:740 → 1030
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:1047 → 1146
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1295 → 1381
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1675 → 1728
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1759 → 1850
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1884 → 1951
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:401 → 474
    APC_rep; Adenomatous polyposis coli (APC) repeat

  13. XM_040655704.2 → XP_040511638.1  adenomatous polyposis coli protein isoform X3

    UniProtKB/TrEMBL
    A0A8V0XZP1
    Conserved Domains (5) summary
    pfam05483
    Location:5 → 262
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00185
    Location:690 → 730
    ARM; Armadillo/beta-catenin-like repeats
    PHA03247
    Location:2289 → 2602
    PHA03247; large tegument protein UL36; Provisional
    sd00043
    Location:506 → 549
    ARM; armadillo repeat [structural motif]
    pfam16689
    Location:4 → 55
    APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain

  14. XM_040655701.2 → XP_040511635.1  adenomatous polyposis coli protein isoform X1

    UniProtKB/TrEMBL
    A0A8V0Y267
    Conserved Domains (4) summary
    smart00185
    Location:702 → 742
    ARM; Armadillo/beta-catenin-like repeats
    PHA03247
    Location:2301 → 2614
    PHA03247; large tegument protein UL36; Provisional
    sd00043
    Location:518 → 561
    ARM; armadillo repeat [structural motif]
    pfam16689
    Location:4 → 67
    APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain

  15. XM_040655711.2 → XP_040511645.1  adenomatous polyposis coli protein isoform X11

    UniProtKB/TrEMBL
    A0A8V0XXR0
    Conserved Domains (3) summary
    smart00185
    Location:576 → 616
    ARM; Armadillo/beta-catenin-like repeats
    PHA03247
    Location:2175 → 2488
    PHA03247; large tegument protein UL36; Provisional
    sd00043
    Location:392 → 435
    ARM; armadillo repeat [structural motif]

  16. XM_040655709.2 → XP_040511643.1  adenomatous polyposis coli protein isoform X9

    UniProtKB/TrEMBL
    A0A8V0Y267
    Conserved Domains (3) summary
    smart00185
    Location:657 → 697
    ARM; Armadillo/beta-catenin-like repeats
    PHA03247
    Location:2256 → 2569
    PHA03247; large tegument protein UL36; Provisional
    sd00043
    Location:473 → 516
    ARM; armadillo repeat [structural motif]

  17. XM_040655706.2 → XP_040511640.1  adenomatous polyposis coli protein isoform X4

    UniProtKB/TrEMBL
    A0A8V0Y267
    Conserved Domains (3) summary
    smart00185
    Location:671 → 711
    ARM; Armadillo/beta-catenin-like repeats
    PHA03247
    Location:2270 → 2583
    PHA03247; large tegument protein UL36; Provisional
    sd00043
    Location:487 → 530
    ARM; armadillo repeat [structural motif]

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_059536.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    46692041..46785098 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046935871.1 → XP_046791827.1  adenomatous polyposis coli protein isoform X10

  2. XM_046935862.1 → XP_046791818.1  adenomatous polyposis coli protein isoform X3

  3. XM_046935868.1 → XP_046791824.1  adenomatous polyposis coli protein isoform X7

    UniProtKB/TrEMBL
    A0A1D5PC88

  4. XM_046935866.1 → XP_046791822.1  adenomatous polyposis coli protein isoform X5

  5. XM_046935861.1 → XP_046791817.1  adenomatous polyposis coli protein isoform X2

  6. XM_046935867.1 → XP_046791823.1  adenomatous polyposis coli protein isoform X6

  7. XM_046935874.1 → XP_046791830.1  adenomatous polyposis coli protein isoform X12

  8. XM_046935858.1 → XP_046791814.1  adenomatous polyposis coli protein isoform X1

  9. XM_046935864.1 → XP_046791820.1  adenomatous polyposis coli protein isoform X3

  10. XM_046935860.1 → XP_046791816.1  adenomatous polyposis coli protein isoform X1

  11. XM_046935872.1 → XP_046791828.1  adenomatous polyposis coli protein isoform X10

  12. XM_046935869.1 → XP_046791825.1  adenomatous polyposis coli protein isoform X8

    UniProtKB/TrEMBL
    A0A8V0Y647

  13. XM_046935863.1 → XP_046791819.1  adenomatous polyposis coli protein isoform X3

  14. XM_046935859.1 → XP_046791815.1  adenomatous polyposis coli protein isoform X1

  15. XM_046935873.1 → XP_046791829.1  adenomatous polyposis coli protein isoform X11

  16. XM_046935870.1 → XP_046791826.1  adenomatous polyposis coli protein isoform X9

  17. XM_046935865.1 → XP_046791821.1  adenomatous polyposis coli protein isoform X4

Nucleotide Protein Strain
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