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POLA1 DNA polymerase alpha 1, catalytic subunit [ Gallus gallus (chicken) ]

Gene ID: 418593, updated on 5-Mar-2024

Summary

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Symbol
POLA1provided by CGNC
Full Name
DNA polymerase alpha 1, catalytic subunitprovided by CGNC
Primary source
CGNC:12201
See related
Ensembl:ENSGALG00010002087
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
POLA
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
39
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (117954768..118146394, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (117983793..118175241, complement)

Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121108996 Neighboring gene uncharacterized LOC112532747 Neighboring gene uncharacterized LOC124417672 Neighboring gene aristaless related homeobox Neighboring gene small Cajal body-specific RNA 24 Neighboring gene uncharacterized LOC101749759 Neighboring gene uncharacterized LOC121109093 Neighboring gene phosphate cytidylyltransferase 1, choline, beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sister group relationship of turtles to the bird-crocodilian clade revealed by nuclear DNA-coded proteins. Iwabe N, et al. Mol Biol Evol, 2005 Apr. PMID 15625185
  2. Chick embryo DNA polymerase alpha. Polypeptide components and their microheterogeneity. Yamaguchi M, et al. J Biol Chem, 1982 Apr 25. PMID 7068647
  3. Immunocytochemical localization of chick DNA polymerases alpha and beta +. Matsukage A, et al. J Cell Physiol, 1983 Nov. PMID 6355128
  4. Monoclonal antibody specific for chicken DNA polymerase alpha associated with DNA primase. Hirose F, et al. Biochem Biophys Res Commun, 1985 Oct 15. PMID 2415123
  5. Ovulation inhibition with different doses of levonorgestrel and other progestogens: clinical and experimental investigations. Spona J, et al. Acta Obstet Gynecol Scand Suppl, 1979. PMID 393050

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. studied the effect of changing from cell proliferation to differentiation on DNA polA and polB
    Title: Differentiation of lens and neural cells in chicken embryos is accompanied by simultaneous decay of DNA replication machinery.
  2. mismatch repair rates and error analysis for chick DNA pol alpha, beta & gamma
    Title: Ovulation inhibition with different doses of levonorgestrel and other progestogens: clinical and experimental investigations.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA replication origin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables DNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables purine nucleotide binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables pyrimidine nucleotide binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in lagging strand elongation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in leading strand elongation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mitotic DNA replication initiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of alpha DNA polymerase:primase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
DNA polymerase alpha catalytic subunit
Names
polymerase (DNA directed), alpha 1, catalytic subunit
polymerase (DNA) alpha 1, catalytic subunit
polymerase (DNA-directed), alpha
XP_015158157.2
XP_015158161.2
XP_040513999.1
XP_040514000.1
XP_040514001.1
XP_040525712.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    117954768..118146394 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015302675.4 → XP_015158161.2  DNA polymerase alpha catalytic subunit isoform X2

    UniProtKB/TrEMBL
    Q59J86
    Conserved Domains (1) summary
    TIGR00592
    Location:41 → 1244
    pol2; DNA polymerase (pol2)

  2. XM_015302671.4 → XP_015158157.2  DNA polymerase alpha catalytic subunit isoform X1

    UniProtKB/TrEMBL
    A0A8V0X4G3, A0A8V0XE03
    Related
    ENSGALP00010002830.1, ENSGALT00010004687.1
    Conserved Domains (1) summary
    TIGR00592
    Location:46 → 1249
    pol2; DNA polymerase (pol2)

  3. XM_040669778.2 → XP_040525712.1  DNA polymerase alpha catalytic subunit isoform X3

    UniProtKB/TrEMBL
    A0A8V0XE03
    Conserved Domains (1) summary
    TIGR00592
    Location:46 → 1249
    pol2; DNA polymerase (pol2)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    117983793..118175241 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040658066.2 → XP_040514000.1  DNA polymerase alpha catalytic subunit isoform X2

    UniProtKB/TrEMBL
    Q59J86
    Conserved Domains (1) summary
    TIGR00592
    Location:41 → 1244
    pol2; DNA polymerase (pol2)

  2. XM_040658065.2 → XP_040513999.1  DNA polymerase alpha catalytic subunit isoform X1

    UniProtKB/TrEMBL
    A0A8V0XE03
    Conserved Domains (1) summary
    TIGR00592
    Location:46 → 1249
    pol2; DNA polymerase (pol2)

  3. XM_040658067.2 → XP_040514001.1  DNA polymerase alpha catalytic subunit isoform X3

    UniProtKB/TrEMBL
    A0A8V0XE03
    Conserved Domains (1) summary
    TIGR00592
    Location:46 → 1249
    pol2; DNA polymerase (pol2)
Nucleotide Protein Strain
Heading Accession and Version

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