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ORF8 ORF8 protein [ Severe acute respiratory syndrome coronavirus 2 ]

Gene ID: 43740577, updated on 7-Apr-2024

Summary

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Gene symbol
ORF8
Gene description
ORF8 protein
Locus tag
GU280_gp09
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Severe acute respiratory syndrome coronavirus 2 (isolate: Wuhan-Hu-1, nat-host: Homo sapiens)
Lineage
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; Betacoronavirus; Sarbecovirus
Summary
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense, single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). Virus particles include the RNA genetic material and structural proteins needed for invasion of host cells. Once inside the cell the infecting RNA is used to encode structural proteins that make up virus particles, nonstructural proteins that direct virus assembly, transcription, replication and host control and accessory proteins whose function has not been determined.~ ORF8 encodes a viral accessory protein.
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Genomic context

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Sequence:
NC_045512.2 (27894..28259)

NC_045512.2Genomic Context describing neighboring genes Neighboring gene ORF6 protein Neighboring gene ORF7a protein Neighboring gene ORF7b Neighboring gene nucleocapsid phosphoprotein Neighboring gene ORF10 protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_045512.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SARS-CoV-2 ORF8 dimerization and binding mode analysis with class I MHC: computational approaches to identify COVID-19 inhibitors. Selvaraj C, et al. Brief Funct Genomics, 2023 Apr 13. PMID 36827221
  2. SARS-CoV-2-encoded ORF8 protein possesses complement inhibitory properties. Kumar J, et al. J Biol Chem, 2023 Mar. PMID 36682494, Free PMC Article
  3. SARS-CoV-2 ORF8 is a viral cytokine regulating immune responses. Kohyama M, et al. Int Immunol, 2023 Jan 21. PMID 36053553, Free PMC Article
  4. SARS-CoV-2 ORF8 reshapes the ER through forming mixed disulfides with ER oxidoreductases. Liu P, et al. Redox Biol, 2022 Aug. PMID 35792438, Free PMC Article
  5. Severe Acute Respiratory Syndrome Coronavirus 2 ORF8 Protein Inhibits Type I Interferon Production by Targeting HSP90B1 Signaling. Chen J, et al. Front Cell Infect Microbiol, 2022. PMID 35677655, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A survey of ORF8 sequence and immunoinformatics features during alpha, delta, and wild type peaks of the SARS-CoV-2 pandemic in Iran.
    Title: A survey of ORF8 sequence and immunoinformatics features during alpha, delta, and wild type peaks of the SARS-CoV-2 pandemic in Iran.
  2. SARS-CoV-2 ORF8 does not function in the nucleus as a histone mimic.
    Title: SARS-CoV-2 ORF8 does not function in the nucleus as a histone mimic.
  3. SARS-CoV-2 ORF8 accessory protein is a virulence factor.
    Title: SARS-CoV-2 ORF8 accessory protein is a virulence factor.
  4. SARS-CoV-2 protein ORF8 limits expression levels of Spike antigen and facilitates immune evasion of infected host cells.
    Title: SARS-CoV-2 protein ORF8 limits expression levels of Spike antigen and facilitates immune evasion of infected host cells.
  5. SARS-CoV-2 ORF8 Mediates Signals in Macrophages and Monocytes through MyD88 Independently of the IL-17 Receptor.
    Title: SARS-CoV-2 ORF8 Mediates Signals in Macrophages and Monocytes through MyD88 Independently of the IL-17 Receptor.
  6. SARS-CoV-2 ORF8 dimerization and binding mode analysis with class I MHC: computational approaches to identify COVID-19 inhibitors.
    Title: SARS-CoV-2 ORF8 dimerization and binding mode analysis with class I MHC: computational approaches to identify COVID-19 inhibitors.
  7. SARS-CoV-2-encoded ORF8 protein possesses complement inhibitory properties.
    Title: SARS-CoV-2-encoded ORF8 protein possesses complement inhibitory properties.
  8. Defective ORF8 dimerization in SARS-CoV-2 delta variant leads to a better adaptive immune response due to abrogation of ORF8-MHC1 interaction.
    Title: Defective ORF8 dimerization in SARS-CoV-2 delta variant leads to a better adaptive immune response due to abrogation of ORF8-MHC1 interaction.
  9. Unconventional secretion of unglycosylated ORF8 is critical for the cytokine storm during SARS-CoV-2 infection.
    Title: Unconventional secretion of unglycosylated ORF8 is critical for the cytokine storm during SARS-CoV-2 infection.
  10. SARS-CoV-2 ORF8 is a viral cytokine regulating immune responses.
    Title: SARS-CoV-2 ORF8 is a viral cytokine regulating immune responses.
Submit: New GeneRIF Correction See all GeneRIFs (29)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General protein information

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Preferred Names
ORF8 protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_045512.2 Reference assembly

    Range
    27894..28259
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_009724396.1 ORF8 protein [Severe acute respiratory syndrome coronavirus 2]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0DTC8
    UniProtKB/TrEMBL
    A0A6B9VTP3, A0A6H2EF95, A0A6H2EIE8, A0A6H2L8G7, A0A6M4N281, A0A6M8DPN5, A0A6M8SX40, A0A6M9TV91, A0A6N0VXW8, A0A6N1D1I1, A0A6N1N6U6, A0A6N1NQU6, A0A6V7AMP5, A0A6V7APK3, A0A7D5FY24, A0A7D7NRW1, A0A7D8A8J2, A0A7H1CZS5, A0A7H2C6H2, A0A7L9W071, A0A7M1FWJ6, A0A7M2F7J0, A0A7U0FCZ1, A0A7U1GF69, A0A7U3ECQ5, A0A886N1N4, A0A8B1JH95, A0A8B1JJM7
    Conserved Domains (1) summary
    cd21641
    Location:1 → 121
    ORF8-Ig_SARS-CoV-2-like; SARS-CoV-2 ORF8 immunoglobulin (Ig) domain protein and related proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DTC8.1 P0DTC8

Gene LinkOut

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