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mnat1 MNAT1 component of CDK activating kinase [ Danio rerio (zebrafish) ]

Gene ID: 450080, updated on 27-Mar-2024

Summary

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Official Symbol
mnat1provided by ZNC
Official Full Name
MNAT1 component of CDK activating kinaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-041010-203
See related
Ensembl:ENSDARG00000002077 AllianceGenome:ZFIN:ZDB-GENE-041010-203
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:101599
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity and metal ion binding activity. Predicted to be involved in DNA repair; regulation of cyclin-dependent protein serine/threonine kinase activity; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within nucleotide-excision repair and positive regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to be located in nucleus. Predicted to be part of transcription factor TFIIH holo complex. Orthologous to human MNAT1 (MNAT1 component of CDK activating kinase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 13
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (31644498..31681951)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (31514047..31551501)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene SIX homeobox 6a Neighboring gene SIX homeobox 1a Neighboring gene SIX homeobox 4a Neighboring gene tRNA methyltransferase 5 Neighboring gene solute carrier family 38 member 6 Neighboring gene protein kinase C, eta, a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolutionary conservation of TFIIH subunits: implications for the use of zebrafish as a model to study TFIIH function and regulation. Silva IA, et al. Comp Biochem Physiol B Biochem Mol Biol, 2014 Jun-Jul. PMID 24731924
  2. Mother-Specific Signature in the Maternal Transcriptome Composition of Mature, Unfertilized Zebrafish Eggs. Rauwerda H, et al. PLoS One, 2016. PMID 26799215, Free PMC Article
  3. Evolutionary comparison reveals that diverging CTCF sites are signatures of ancestral topological associating domains borders. Gómez-Marín C, et al. Proc Natl Acad Sci U S A, 2015 Jun 16. PMID 26034287, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nucleotide-excision repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIIH holo complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIH holo complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CDK-activating kinase assembly factor MAT1
Names
MNAT CDK-activating kinase assembly factor 1
menage a trois homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006100.1 → NP_001006100.1  CDK-activating kinase assembly factor MAT1

    See identical proteins and their annotated locations for NP_001006100.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083216
    UniProtKB/TrEMBL
    Q5XJT0
    Related
    ENSDARP00000027502.7, ENSDART00000006648.8
    Conserved Domains (3) summary
    TIGR00570
    Location:1 → 307
    cdk7; CDK-activating kinase assembly factor MAT1
    cl17238
    Location:3 → 46
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl21478
    Location:166 → 218
    ATP-synt_B; ATP synthase B/B' CF(0)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    31644498..31681951
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009307310.3 → XP_009305585.1  CDK-activating kinase assembly factor MAT1 isoform X1

    UniProtKB/TrEMBL
    A0A8M3BEN4, B8A5G8
    Conserved Domains (3) summary
    TIGR00570
    Location:1 → 307
    cdk7; CDK-activating kinase assembly factor MAT1
    cl17238
    Location:3 → 46
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl21478
    Location:166 → 218
    ATP-synt_B; ATP synthase B/B' CF(0)

  2. XM_017358735.2 → XP_017214224.1  CDK-activating kinase assembly factor MAT1 isoform X1

    UniProtKB/TrEMBL
    A0A8M3BEN4, B8A5G8
    Conserved Domains (3) summary
    TIGR00570
    Location:1 → 307
    cdk7; CDK-activating kinase assembly factor MAT1
    cl17238
    Location:3 → 46
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl21478
    Location:166 → 218
    ATP-synt_B; ATP synthase B/B' CF(0)
Nucleotide Protein
Heading Accession and Version

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