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ALAS1 5'-aminolevulinate synthase 1 [ Pan troglodytes (chimpanzee) ]

Gene ID: 460416, updated on 3-Apr-2024

Summary

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Official Symbol
ALAS1provided by VGNC
Official Full Name
5'-aminolevulinate synthase 1provided by VGNC
Primary source
VGNC:VGNC:1728
Locus tag
CK820_G0004995
See related
Ensembl:ENSPTRG00000014991
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 2 NC_086015.1 (56243234..56259465)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 3 NC_072401.1 (56242908..56259136)

Chromosome 2 - NC_086015.1Genomic Context describing neighboring genes Neighboring gene POC1 centriolar protein A Neighboring gene fructose-bisphosphate aldolase A-like Neighboring gene twinfilin actin binding protein 2 Neighboring gene uncharacterized LOC134809446 Neighboring gene twinfilin actin binding protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 5-aminolevulinate synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in erythrocyte development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in heme biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hemoglobin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
5-aminolevulinate synthase, nonspecific, mitochondrial; 5-aminolevulinate synthase, non-specific, mitochondrial
Names
aminolevulinate, delta, synthase 1
aminolevulinate, delta-, synthase 1
XP_009443860.1
XP_054537902.1
XP_054537903.1
XP_063662881.1
XP_516501.2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_086015.1 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    56243234..56259465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_516501.7 → XP_516501.2  5-aminolevulinate synthase, non-specific, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_516501.2

    UniProtKB/TrEMBL
    A0A2J8P8J0, A0A6D2VSE5, H2QMR0, K7DQ03
    Related
    ENSPTRP00000025879.4
    Conserved Domains (2) summary
    pfam09029
    Location:2 → 137
    Preseq_ALAS; 5-aminolevulinate synthase presequence
    cl18945
    Location:197 → 602
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

  2. XM_009445585.2 → XP_009443860.1  5-aminolevulinate synthase, non-specific, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_009443860.1

    UniProtKB/TrEMBL
    A0A2J8P8J0, A0A6D2VSE5, H2QMR0, K7DQ03
    Conserved Domains (2) summary
    pfam09029
    Location:2 → 137
    Preseq_ALAS; 5-aminolevulinate synthase presequence
    cl18945
    Location:197 → 602
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

  3. XM_054681928.2 → XP_054537903.1  5-aminolevulinate synthase, non-specific, mitochondrial isoform X2

  4. XM_063806811.1 → XP_063662881.1  5-aminolevulinate synthase, non-specific, mitochondrial isoform X2

  5. XM_054681927.2 → XP_054537902.1  5-aminolevulinate synthase, non-specific, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A2J8P8J0, A0A6D2VSE5, H2QMR0

RNA

  1. XR_010155599.1 RNA Sequence

Nucleotide Protein
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