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CASP3 caspase 3 [ Pan troglodytes (chimpanzee) ]

Gene ID: 461669, updated on 3-Apr-2024

Summary

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Official Symbol
CASP3provided by VGNC
Official Full Name
caspase 3provided by VGNC
Primary source
VGNC:VGNC:2081
Locus tag
CK820_G0031735
See related
Ensembl:ENSPTRG00000016640
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 4
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 3 NC_072401.2 (186269277..186291091, complement)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 4 NC_072402.1 (186228687..186250471, complement)

Chromosome 3 - NC_072401.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134809942 Neighboring gene H/ACA ribonucleoprotein complex subunit 1-like Neighboring gene primase and DNA directed polymerase Neighboring gene centromere protein U

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Accelerated evolution of nervous system genes in the origin of Homo sapiens. Dorus S, et al. Cell, 2004 Dec 29. PMID 15620360

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in keratinocyte differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuron differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
caspase-3
Names
CASP-3
caspase 3, apoptosis-related cysteine peptidase
NP_001012435.1
XP_009446811.1
XP_009446812.1
XP_009446814.1
XP_016806492.1
XP_016806493.1
XP_063664519.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012433.1 → NP_001012435.1  caspase-3

    See identical proteins and their annotated locations for NP_001012435.1

    Status: PROVISIONAL

    Source sequence(s)
    AY665274
    UniProtKB/Swiss-Prot
    Q5IS54
    UniProtKB/TrEMBL
    A0A2J8L8A3, A0A663DA81, K7D0A9
    Conserved Domains (1) summary
    smart00115
    Location:37 → 277
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072401.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    186269277..186291091 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009448537.5 → XP_009446812.1  caspase-3 isoform X2

    See identical proteins and their annotated locations for XP_009446812.1

    UniProtKB/Swiss-Prot
    Q5IS54
    UniProtKB/TrEMBL
    A0A2J8L8A3, A0A663DA81, K7D0A9
    Conserved Domains (1) summary
    smart00115
    Location:37 → 277
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

  2. XM_009448536.5 → XP_009446811.1  caspase-3 isoform X1

    Conserved Domains (1) summary
    smart00115
    Location:52 → 292
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

  3. XM_016951003.4 → XP_016806492.1  caspase-3 isoform X2

    UniProtKB/Swiss-Prot
    Q5IS54
    UniProtKB/TrEMBL
    A0A2J8L8A3, A0A663DA81, K7D0A9
    Conserved Domains (1) summary
    smart00115
    Location:37 → 277
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

  4. XM_009448539.5 → XP_009446814.1  caspase-3 isoform X2

    See identical proteins and their annotated locations for XP_009446814.1

    UniProtKB/Swiss-Prot
    Q5IS54
    UniProtKB/TrEMBL
    A0A2J8L8A3, A0A663DA81, K7D0A9
    Conserved Domains (1) summary
    smart00115
    Location:37 → 277
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

  5. XM_016951004.4 → XP_016806493.1  caspase-3 isoform X2

    UniProtKB/Swiss-Prot
    Q5IS54
    UniProtKB/TrEMBL
    A0A2J8L8A3, A0A663DA81, K7D0A9
    Conserved Domains (1) summary
    smart00115
    Location:37 → 277
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

  6. XM_063808449.1 → XP_063664519.1  caspase-3 isoform X2

    UniProtKB/Swiss-Prot
    Q5IS54
    UniProtKB/TrEMBL
    A0A2J8L8A3, A0A663DA81, K7D0A9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5IS54.1 GenPept UniProtKB/Swiss-Prot:Q5IS54

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