CDKN2A cyclin dependent kinase inhibitor 2A [Pan troglodytes (chimpanzee)] - Gene

Summary

Gene symbol: CDKN2A
Gene description: cyclin dependent kinase inhibitor 2A
Locus tag: CK820_G0014549
See related: Ensembl:ENSPTRG00000020827
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human all
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Genomic context

Location:: chromosome: 11

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	11	NC_072409.2 (93924729..93951400)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	9	NC_072407.1 (24917319..24944001, complement)

Chromosome 11 - NC_072409.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH67869 (e-PCR)
- UniSTS:58120

GDB:434761 (e-PCR)
- UniSTS:157208

GDB:437702 (e-PCR)
- UniSTS:157253

GDB:437709 (e-PCR)
- UniSTS:157254

GDB:572854 (e-PCR)
- UniSTS:157772

RH103023 (e-PCR)
- UniSTS:97357

GDB:572861 (e-PCR)
- UniSTS:157774

D9S2060 (e-PCR)
- UniSTS:27737

PMC140684P1 (e-PCR)
- UniSTS:270960

PMC140684P2 (e-PCR)
- UniSTS:270961

GDB:679537 (e-PCR)
- UniSTS:158612

GDB:679538 (e-PCR)
- UniSTS:158613

D9S2143 (e-PCR)
- UniSTS:474520

PMC25103P3 (e-PCR)
- UniSTS:272283

GDB:626084 (e-PCR)
- UniSTS:158388

GDB:626104 (e-PCR)
- UniSTS:158391

GDB:626109 (e-PCR)
- UniSTS:158392

GDB:626123 (e-PCR)
- UniSTS:158393

GDB:626126 (e-PCR)
- UniSTS:158394

STS-S69824 (e-PCR)
- UniSTS:27844

PMC92514P2 (e-PCR)
- UniSTS:273616

PMC92514P4 (e-PCR)
- UniSTS:273618

PMC33151P1 (e-PCR)
- UniSTS:273151

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase inhibitor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: cyclin-dependent kinase inhibitor 2A

Names: cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001146290.1 → NP_001139762.1 cyclin-dependent kinase inhibitor 2A

See identical proteins and their annotated locations for NP_001139762.1

Status: PROVISIONAL

Source sequence(s)

JAQQLN020000011

UniProtKB/TrEMBL

A0A2I3RN44, A0A2J8QSI7, A0A2J8QSK7, A0A6D2W058, A0A6D2XAZ8, H2QX30

Related

ENSPTRP00000035617.4, ENSPTRT00000038532.5

Conserved Domains (2) summary

cd00204
Location:19 → 130

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:16 → 42

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072409.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

93924729..93951400

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054657805.2 → XP_054513780.1 cyclin-dependent kinase inhibitor 2A isoform X1

UniProtKB/TrEMBL

A0A2J8QSJ5
XM_054657804.2 → XP_054513779.1 cyclin-dependent kinase inhibitor 2A isoform X1

UniProtKB/TrEMBL

A0A2J8QSJ5