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PRKDC protein kinase, DNA-activated, catalytic subunit [ Canis lupus familiaris (dog) ]

Gene ID: 474176, updated on 5-Mar-2024

Summary

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Official Symbol
PRKDCprovided by VGNC
Official Full Name
protein kinase, DNA-activated, catalytic subunitprovided by VGNC
Primary source
VGNC:VGNC:44989
See related
Ensembl:ENSCAFG00845027748
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
DNA-PKcs
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 29
Exon count:
87
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 29 NC_051833.1 (20665..241975, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 29 NC_006611.4 (449958..669362, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 29 NC_049250.1 (285564..503393, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 29 NC_049289.1 (20944..240298, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 29 NC_049770.1 (218160..435150, complement)

Chromosome 29 - NC_051833.1Genomic Context describing neighboring genes Neighboring gene minichromosome maintenance complex component 4 Neighboring gene cytochrome c oxidase subunit 7B, mitochondrial-like Neighboring gene ubiquitin conjugating enzyme E2 V2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DNA-PKcs mutations in dogs and horses: allele frequency and association with neoplasia. Ding Q, et al. Gene, 2002 Jan 23. PMID 11867233

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in double-strand break repair via nonhomologous end joining IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immunoglobulin V(D)J recombination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in telomere maintenance IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
DNA-dependent protein kinase catalytic subunit
Names
DNA-PK catalytic subunit
protein kinase, DNA-activated, catalytic polypeptide
XP_038296989.1
XP_038296990.1
XP_038296991.1
XP_038296992.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006651.3 → NP_001006652.3  DNA-dependent protein kinase catalytic subunit

    Status: VALIDATED

    Source sequence(s)
    JAAUVH010000364
    UniProtKB/TrEMBL
    A0A8I3PUI7, A0A8I3SB89
    Related
    ENSCAFP00845038476.1, ENSCAFT00845049037.1
    Conserved Domains (4) summary
    COG5032
    Location:3490 → 4134
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05172
    Location:3725 → 4021
    PIKKc_DNA-PK; Catalytic domain of DNA-dependent protein kinase
    pfam02259
    Location:3029 → 3476
    FAT; FAT domain
    pfam08163
    Location:1819 → 2204
    NUC194; NUC194 domain

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051833.1 Reference ROS_Cfam_1.0

    Range
    20665..241975 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038441062.1 → XP_038296990.1  DNA-dependent protein kinase catalytic subunit isoform X2

    UniProtKB/TrEMBL
    A0A8I3SB89
    Conserved Domains (4) summary
    COG5032
    Location:3450 → 4094
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05172
    Location:3685 → 3981
    PIKKc_DNA-PK; Catalytic domain of DNA-dependent protein kinase
    pfam02259
    Location:2989 → 3436
    FAT; FAT domain
    pfam08163
    Location:1779 → 2164
    NUC194; NUC194 domain

  2. XM_038441064.1 → XP_038296992.1  DNA-dependent protein kinase catalytic subunit isoform X4

    UniProtKB/TrEMBL
    A0A8I3SB89
    Conserved Domains (4) summary
    COG5032
    Location:3437 → 4081
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05172
    Location:3672 → 3968
    PIKKc_DNA-PK; Catalytic domain of DNA-dependent protein kinase
    pfam02259
    Location:2976 → 3423
    FAT; FAT domain
    pfam08163
    Location:1766 → 2151
    NUC194; NUC194 domain

  3. XM_038441063.1 → XP_038296991.1  DNA-dependent protein kinase catalytic subunit isoform X3

    UniProtKB/TrEMBL
    A0A8I3SB89
    Conserved Domains (4) summary
    COG5032
    Location:3440 → 4084
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05172
    Location:3675 → 3971
    PIKKc_DNA-PK; Catalytic domain of DNA-dependent protein kinase
    pfam02259
    Location:2979 → 3426
    FAT; FAT domain
    pfam08163
    Location:1819 → 2204
    NUC194; NUC194 domain

  4. XM_038441061.1 → XP_038296989.1  DNA-dependent protein kinase catalytic subunit isoform X1

    UniProtKB/TrEMBL
    A0A8I3SB89
    Conserved Domains (4) summary
    COG5032
    Location:3489 → 4133
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05172
    Location:3724 → 4020
    PIKKc_DNA-PK; Catalytic domain of DNA-dependent protein kinase
    pfam02259
    Location:3029 → 3475
    FAT; FAT domain
    pfam08163
    Location:1819 → 2204
    NUC194; NUC194 domain

RNA

  1. XR_005304005.1 RNA Sequence

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049289.1 Alternate UMICH_Zoey_3.1

    Range
    20944..240298 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049770.1 Alternate UNSW_CanFamBas_1.0

    Range
    218160..435150 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049250.1 Alternate UU_Cfam_GSD_1.0

    Range
    285564..503393 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006611.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    449958..669362 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WN22.1 GenPept UniProtKB/Swiss-Prot:Q8WN22

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