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APOE apolipoprotein E [ Canis lupus familiaris (dog) ]

Gene ID: 476438, updated on 5-Mar-2024

Summary

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Official Symbol
APOEprovided by VGNC
Official Full Name
apolipoprotein Eprovided by VGNC
Primary source
VGNC:VGNC:38002
See related
Ensembl:ENSCAFG00845006705
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
Apo-E
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
4
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 1 NC_051805.1 (111055483..111058288, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 1 NC_006583.4 (110006660..110009463, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 1 NC_049222.1 (111234400..111237204, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 1 NC_049261.1 (110730139..110732942, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 1 NC_049742.1 (110365616..110368413, complement)

Chromosome 1 - NC_051805.1Genomic Context describing neighboring genes Neighboring gene apolipoprotein C4 Neighboring gene apolipoprotein C1 Neighboring gene translocase of outer mitochondrial membrane 40 Neighboring gene nectin cell adhesion molecule 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dogs lacking Apolipoprotein E show advanced atherosclerosis leading to apparent clinical complications. Zhao H, et al. Sci China Life Sci, 2022 Jul. PMID 34705220
  2. Generation of ApoE deficient dogs via combination of embryo injection of CRISPR/Cas9 with somatic cell nuclear transfer. Feng C, et al. J Genet Genomics, 2018 Jan 20. PMID 29396142
  3. Structure and expression of dog apolipoprotein A-I, E, and C-I mRNAs: implications for the evolution and functional constraints of apolipoprotein structure. Luo CC, et al. J Lipid Res, 1989 Nov. PMID 2515239
  4. Cloning, sequencing and expression in the dog of the main amyloid precursor protein isoforms and some of the enzymes related with their processing. Sarasa L, et al. Neuroscience, 2010 Dec 29. PMID 20875843

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables amyloid-beta binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables low-density lipoprotein particle receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables very-low-density lipoprotein particle receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cholesterol catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in lipoprotein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of nitric-oxide synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of amyloid-beta clearance IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of intermediate-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
apolipoprotein E
Names
apolipoprotein E4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051805.1 Reference ROS_Cfam_1.0

    Range
    111055483..111058288 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038656704.1 → XP_038512632.1  apolipoprotein E

    UniProtKB/Swiss-Prot
    F1PJ74, P18649
    UniProtKB/TrEMBL
    A0A8C0KEX2, A0A8C0M3L6
    Conserved Domains (1) summary
    pfam01442
    Location:92 → 279
    Apolipoprotein; Apolipoprotein A1/A4/E domain

  2. XM_038656703.1 → XP_038512631.1  apolipoprotein E

    UniProtKB/Swiss-Prot
    F1PJ74, P18649
    UniProtKB/TrEMBL
    A0A8C0KEX2, A0A8C0M3L6
    Conserved Domains (1) summary
    pfam01442
    Location:92 → 279
    Apolipoprotein; Apolipoprotein A1/A4/E domain

  3. XM_038656705.1 → XP_038512633.1  apolipoprotein E

    UniProtKB/Swiss-Prot
    F1PJ74, P18649
    UniProtKB/TrEMBL
    A0A8C0KEX2, A0A8C0M3L6
    Related
    ENSCAFP00845009282.1, ENSCAFT00845011898.1
    Conserved Domains (1) summary
    pfam01442
    Location:92 → 279
    Apolipoprotein; Apolipoprotein A1/A4/E domain

  4. XM_038656706.1 → XP_038512634.1  apolipoprotein E

    UniProtKB/Swiss-Prot
    F1PJ74, P18649
    UniProtKB/TrEMBL
    A0A8C0KEX2, A0A8C0M3L6
    Conserved Domains (1) summary
    pfam01442
    Location:92 → 279
    Apolipoprotein; Apolipoprotein A1/A4/E domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049261.1 Alternate UMICH_Zoey_3.1

    Range
    110730139..110732942 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038467900.1 → XP_038323828.1  apolipoprotein E

    Conserved Domains (1) summary
    pfam01442
    Location:92 → 279
    Apolipoprotein; Apolipoprotein A1/A4/E domain

  2. XM_038467899.1 → XP_038323827.1  apolipoprotein E

    Conserved Domains (1) summary
    pfam01442
    Location:92 → 279
    Apolipoprotein; Apolipoprotein A1/A4/E domain

  3. XM_038467901.1 → XP_038323829.1  apolipoprotein E

    Conserved Domains (1) summary
    pfam01442
    Location:92 → 279
    Apolipoprotein; Apolipoprotein A1/A4/E domain

  4. XM_038467902.1 → XP_038323830.1  apolipoprotein E

    Conserved Domains (1) summary
    pfam01442
    Location:92 → 279
    Apolipoprotein; Apolipoprotein A1/A4/E domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049742.1 Alternate UNSW_CanFamBas_1.0

    Range
    110365616..110368413 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038592898.1 → XP_038448826.1  apolipoprotein E

    Conserved Domains (1) summary
    pfam01442
    Location:92 → 279
    Apolipoprotein; Apolipoprotein A1/A4/E domain

  2. XM_038592897.1 → XP_038448825.1  apolipoprotein E

    Conserved Domains (1) summary
    pfam01442
    Location:92 → 279
    Apolipoprotein; Apolipoprotein A1/A4/E domain

  3. XM_038592899.1 → XP_038448827.1  apolipoprotein E

    Conserved Domains (1) summary
    pfam01442
    Location:92 → 279
    Apolipoprotein; Apolipoprotein A1/A4/E domain

  4. XM_038592900.1 → XP_038448828.1  apolipoprotein E

    Conserved Domains (1) summary
    pfam01442
    Location:92 → 279
    Apolipoprotein; Apolipoprotein A1/A4/E domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049222.1 Alternate UU_Cfam_GSD_1.0

    Range
    111234400..111237204 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038528614.1 → XP_038384542.1  apolipoprotein E

    UniProtKB/Swiss-Prot
    F1PJ74, P18649
    UniProtKB/TrEMBL
    A0A8C0KEX2, A0A8C0M3L6
    Conserved Domains (1) summary
    pfam01442
    Location:92 → 279
    Apolipoprotein; Apolipoprotein A1/A4/E domain

  2. XM_038528613.1 → XP_038384541.1  apolipoprotein E

    UniProtKB/Swiss-Prot
    F1PJ74, P18649
    UniProtKB/TrEMBL
    A0A8C0KEX2, A0A8C0M3L6
    Conserved Domains (1) summary
    pfam01442
    Location:92 → 279
    Apolipoprotein; Apolipoprotein A1/A4/E domain

  3. XM_038528615.1 → XP_038384543.1  apolipoprotein E

    UniProtKB/Swiss-Prot
    F1PJ74, P18649
    UniProtKB/TrEMBL
    A0A8C0KEX2, A0A8C0M3L6
    Conserved Domains (1) summary
    pfam01442
    Location:92 → 279
    Apolipoprotein; Apolipoprotein A1/A4/E domain

  4. XM_038528616.1 → XP_038384544.1  apolipoprotein E

    UniProtKB/Swiss-Prot
    F1PJ74, P18649
    UniProtKB/TrEMBL
    A0A8C0KEX2, A0A8C0M3L6
    Conserved Domains (1) summary
    pfam01442
    Location:92 → 279
    Apolipoprotein; Apolipoprotein A1/A4/E domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    110006660..110009463 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_533644.7 → XP_533644.1  apolipoprotein E

    See identical proteins and their annotated locations for XP_533644.1

    UniProtKB/Swiss-Prot
    F1PJ74, P18649
    UniProtKB/TrEMBL
    A0A8C0KEX2, A0A8C0M3L6
    Conserved Domains (1) summary
    pfam01442
    Location:92 → 279
    Apolipoprotein; Apolipoprotein A1/A4/E domain

  2. XM_005616460.4 → XP_005616517.2  apolipoprotein E

    UniProtKB/Swiss-Prot
    F1PJ74, P18649
    UniProtKB/TrEMBL
    A0A8C0KEX2, A0A8C0M3L6
    Conserved Domains (1) summary
    pfam01442
    Location:92 → 279
    Apolipoprotein; Apolipoprotein A1/A4/E domain

  3. XM_860950.5 → XP_866043.1  apolipoprotein E

    See identical proteins and their annotated locations for XP_866043.1

    UniProtKB/Swiss-Prot
    F1PJ74, P18649
    UniProtKB/TrEMBL
    A0A8C0KEX2, A0A8C0M3L6
    Conserved Domains (1) summary
    pfam01442
    Location:92 → 279
    Apolipoprotein; Apolipoprotein A1/A4/E domain

  4. XM_022425020.2 → XP_022280728.1  apolipoprotein E

    UniProtKB/Swiss-Prot
    F1PJ74, P18649
    UniProtKB/TrEMBL
    A0A8C0KEX2, A0A8C0M3L6
    Conserved Domains (1) summary
    pfam01442
    Location:92 → 279
    Apolipoprotein; Apolipoprotein A1/A4/E domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18649.3 GenPept UniProtKB/Swiss-Prot:P18649

Gene LinkOut

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