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ABCB4 ATP binding cassette subfamily B member 4 [ Canis lupus familiaris (dog) ]

Gene ID: 482284, updated on 5-Mar-2024

Summary

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Official Symbol
ABCB4provided by VGNC
Official Full Name
ATP binding cassette subfamily B member 4provided by VGNC
Primary source
VGNC:VGNC:37434
See related
Ensembl:ENSCAFG00845007730
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human all
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Genomic context

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Location:
chromosome: 14
Exon count:
28
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 14 NC_051818.1 (13307604..13379530, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 14 NC_006596.4 (13114115..13185936, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 14 NC_049235.1 (13520259..13592210, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 14 NC_049274.1 (13510779..13582706, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 14 NC_049755.1 (13236739..13308588, complement)

Chromosome 14 - NC_051818.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111098739 Neighboring gene carnitine O-octanoyltransferase Neighboring gene ATP binding cassette subfamily B member 1 Neighboring gene RUN domain containing 3B Neighboring gene small ubiquitin-related modifier 2-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Canine ABCB4: Tissue expression and cDNA structure. Spencer ES, et al. Res Vet Sci, 2010 Aug. PMID 20153493
  2. Effects of cellular, chemical, and pharmacological chaperones on the rescue of a trafficking-defective mutant of the ATP-binding cassette transporter proteins ABCB1/ABCB4. Gautherot J, et al. J Biol Chem, 2012 Feb 10. PMID 22184139, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Effects of cellular, chemical, and pharmacological chaperones on the rescue of a trafficking-defective mutant of the ATP-binding cassette transporter proteins ABCB1/ABCB4.
    Title: Effects of cellular, chemical, and pharmacological chaperones on the rescue of a trafficking-defective mutant of the ATP-binding cassette transporter proteins ABCB1/ABCB4.
  2. The full cDNA sequence of canine ABCB4 was elucidated and its mRNA and protein expression levels in tissues were determined.
    Title: Canine ABCB4: Tissue expression and cDNA structure.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylcholine translocator ABCB4
XP_013974663.2
XP_022282996.2
XP_038299678.1
XP_038299689.1
XP_038299690.1
XP_038299693.1
XP_038350316.1
XP_038350317.1
XP_038350318.1
XP_038350319.1
XP_038350320.1
XP_038350321.1
XP_038350322.1
XP_038412611.1
XP_038412612.1
XP_038412613.1
XP_038412614.1
XP_038412615.1
XP_038412616.1
XP_038412617.1
XP_038476546.1
XP_038476547.1
XP_038476548.1
XP_038476549.1
XP_038476550.1
XP_038476551.1
XP_038476552.1
XP_038542235.1
XP_038542236.1
XP_038542237.1
XP_038542238.1
XP_038542239.1
XP_038542240.1
XP_038542241.1
XP_539403.4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051818.1 Reference ROS_Cfam_1.0

    Range
    13307604..13379530 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038686311.1 → XP_038542239.1  phosphatidylcholine translocator ABCB4 isoform X4

    UniProtKB/TrEMBL
    A0A8C0SGW1
    Conserved Domains (1) summary
    PTZ00265
    Location:14 → 1228
    PTZ00265; multidrug resistance protein (mdr1); Provisional

  2. XM_038686310.1 → XP_038542238.1  phosphatidylcholine translocator ABCB4 isoform X3

    UniProtKB/TrEMBL
    A0A8C0R5C0
    Conserved Domains (1) summary
    PTZ00265
    Location:19 → 1235
    PTZ00265; multidrug resistance protein (mdr1); Provisional

  3. XM_038686308.1 → XP_038542236.1  phosphatidylcholine translocator ABCB4 isoform X1

    UniProtKB/TrEMBL
    A0A8I3N6T3
    Related
    ENSCAFP00845010591.1, ENSCAFT00845013639.1
    Conserved Domains (1) summary
    PTZ00265
    Location:26 → 1268
    PTZ00265; multidrug resistance protein (mdr1); Provisional

  4. XM_038686309.1 → XP_038542237.1  phosphatidylcholine translocator ABCB4 isoform X2

    UniProtKB/TrEMBL
    A0A8I3N6T3
    Conserved Domains (1) summary
    PTZ00265
    Location:47 → 1261
    PTZ00265; multidrug resistance protein (mdr1); Provisional

  5. XM_038686307.1 → XP_038542235.1  phosphatidylcholine translocator ABCB4 isoform X1

    UniProtKB/TrEMBL
    A0A8I3N6T3
    Conserved Domains (1) summary
    PTZ00265
    Location:26 → 1268
    PTZ00265; multidrug resistance protein (mdr1); Provisional

  6. XM_038686312.1 → XP_038542240.1  phosphatidylcholine translocator ABCB4 isoform X5

    UniProtKB/TrEMBL
    A0A8C0SGW1
    Conserved Domains (1) summary
    PTZ00265
    Location:3 → 1075
    PTZ00265; multidrug resistance protein (mdr1); Provisional

  7. XM_038686313.1 → XP_038542241.1  phosphatidylcholine translocator ABCB4 isoform X6

    UniProtKB/TrEMBL
    A0A8C0SGW1
    Conserved Domains (1) summary
    PTZ00265
    Location:37 → 1048
    PTZ00265; multidrug resistance protein (mdr1); Provisional

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049274.1 Alternate UMICH_Zoey_3.1

    Range
    13510779..13582706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038494392.1 → XP_038350320.1  phosphatidylcholine translocator ABCB4 isoform X4

    Conserved Domains (1) summary
    PTZ00265
    Location:14 → 1228
    PTZ00265; multidrug resistance protein (mdr1); Provisional

  2. XM_038494391.1 → XP_038350319.1  phosphatidylcholine translocator ABCB4 isoform X3

    Conserved Domains (1) summary
    PTZ00265
    Location:19 → 1235
    PTZ00265; multidrug resistance protein (mdr1); Provisional

  3. XM_038494389.1 → XP_038350317.1  phosphatidylcholine translocator ABCB4 isoform X1

    Conserved Domains (1) summary
    PTZ00265
    Location:26 → 1268
    PTZ00265; multidrug resistance protein (mdr1); Provisional

  4. XM_038494390.1 → XP_038350318.1  phosphatidylcholine translocator ABCB4 isoform X2

    Conserved Domains (1) summary
    PTZ00265
    Location:47 → 1261
    PTZ00265; multidrug resistance protein (mdr1); Provisional

  5. XM_038494388.1 → XP_038350316.1  phosphatidylcholine translocator ABCB4 isoform X1

    Conserved Domains (1) summary
    PTZ00265
    Location:26 → 1268
    PTZ00265; multidrug resistance protein (mdr1); Provisional

  6. XM_038494393.1 → XP_038350321.1  phosphatidylcholine translocator ABCB4 isoform X5

    Conserved Domains (1) summary
    PTZ00265
    Location:3 → 1075
    PTZ00265; multidrug resistance protein (mdr1); Provisional

  7. XM_038494394.1 → XP_038350322.1  phosphatidylcholine translocator ABCB4 isoform X6

    Conserved Domains (1) summary
    PTZ00265
    Location:37 → 1048
    PTZ00265; multidrug resistance protein (mdr1); Provisional

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049755.1 Alternate UNSW_CanFamBas_1.0

    Range
    13236739..13308588 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038620622.1 → XP_038476550.1  phosphatidylcholine translocator ABCB4 isoform X4

  2. XM_038620621.1 → XP_038476549.1  phosphatidylcholine translocator ABCB4 isoform X3

  3. XM_038620619.1 → XP_038476547.1  phosphatidylcholine translocator ABCB4 isoform X1

  4. XM_038620620.1 → XP_038476548.1  phosphatidylcholine translocator ABCB4 isoform X2

  5. XM_038620618.1 → XP_038476546.1  phosphatidylcholine translocator ABCB4 isoform X1

  6. XM_038620623.1 → XP_038476551.1  phosphatidylcholine translocator ABCB4 isoform X5

  7. XM_038620624.1 → XP_038476552.1  phosphatidylcholine translocator ABCB4 isoform X6

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049235.1 Alternate UU_Cfam_GSD_1.0

    Range
    13520259..13592210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038556687.1 → XP_038412615.1  phosphatidylcholine translocator ABCB4 isoform X4

    UniProtKB/TrEMBL
    A0A8C0SGW1

  2. XM_038556686.1 → XP_038412614.1  phosphatidylcholine translocator ABCB4 isoform X3

    UniProtKB/TrEMBL
    A0A8C0R5C0

  3. XM_038556684.1 → XP_038412612.1  phosphatidylcholine translocator ABCB4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0MH38, A0A8I3N6T3

  4. XM_038556685.1 → XP_038412613.1  phosphatidylcholine translocator ABCB4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0MH38, A0A8I3N6T3

  5. XM_038556683.1 → XP_038412611.1  phosphatidylcholine translocator ABCB4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0MH38, A0A8I3N6T3

  6. XM_038556688.1 → XP_038412616.1  phosphatidylcholine translocator ABCB4 isoform X5

    UniProtKB/TrEMBL
    A0A8C0SGW1

  7. XM_038556689.1 → XP_038412617.1  phosphatidylcholine translocator ABCB4 isoform X6

    UniProtKB/TrEMBL
    A0A8C0SGW1

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006596.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    13114115..13185936 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038443762.1 → XP_038299690.1  phosphatidylcholine translocator ABCB4 isoform X4

    UniProtKB/TrEMBL
    A0A8C0SGW1
    Conserved Domains (1) summary
    PTZ00265
    Location:14 → 1228
    PTZ00265; multidrug resistance protein (mdr1); Provisional

  2. XM_038443761.1 → XP_038299689.1  phosphatidylcholine translocator ABCB4 isoform X3

    UniProtKB/TrEMBL
    A0A8C0R5C0
    Conserved Domains (1) summary
    PTZ00265
    Location:19 → 1235
    PTZ00265; multidrug resistance protein (mdr1); Provisional

  3. XM_539403.7 → XP_539403.4  phosphatidylcholine translocator ABCB4 isoform X1

    UniProtKB/TrEMBL
    A0A8I3N6T3
    Conserved Domains (1) summary
    PTZ00265
    Location:26 → 1268
    PTZ00265; multidrug resistance protein (mdr1); Provisional

  4. XM_014119188.3 → XP_013974663.2  phosphatidylcholine translocator ABCB4 isoform X2

    UniProtKB/TrEMBL
    A0A8I3N6T3
    Conserved Domains (1) summary
    PTZ00265
    Location:47 → 1261
    PTZ00265; multidrug resistance protein (mdr1); Provisional

  5. XM_038443750.1 → XP_038299678.1  phosphatidylcholine translocator ABCB4 isoform X1

    UniProtKB/TrEMBL
    A0A8I3N6T3
    Conserved Domains (1) summary
    PTZ00265
    Location:26 → 1268
    PTZ00265; multidrug resistance protein (mdr1); Provisional

  6. XM_022427288.2 → XP_022282996.2  phosphatidylcholine translocator ABCB4 isoform X5

    UniProtKB/TrEMBL
    A0A8C0SGW1
    Conserved Domains (1) summary
    PTZ00265
    Location:3 → 1075
    PTZ00265; multidrug resistance protein (mdr1); Provisional

  7. XM_038443765.1 → XP_038299693.1  phosphatidylcholine translocator ABCB4 isoform X6

    UniProtKB/TrEMBL
    A0A8C0SGW1
    Conserved Domains (1) summary
    PTZ00265
    Location:37 → 1048
    PTZ00265; multidrug resistance protein (mdr1); Provisional
Nucleotide Protein
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