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PTCH2 patched 2 [ Canis lupus familiaris (dog) ]

Gene ID: 482519, updated on 5-Mar-2024

Summary

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Official Symbol
PTCH2provided by VGNC
Official Full Name
patched 2provided by VGNC
Primary source
VGNC:VGNC:45133
See related
Ensembl:ENSCAFG00845025530
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See PTCH2 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
22
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 15 NC_051819.1 (15643729..15659090)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 15 NC_006597.4 (15608551..15623939)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 15 NC_049236.1 (15581190..15596607)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 15 NC_049275.1 (15440572..15455919)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 15 NC_049756.1 (15508480..15523831)

Chromosome 15 - NC_051819.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2B subunit gamma Neighboring gene 40S ribosomal protein S29-like Neighboring gene eukaryotic translation initiation factor 4E type 2-like Neighboring gene uncharacterized LOC119869327 Neighboring gene U5 spliceosomal RNA Neighboring gene BTB domain containing 19 Neighboring gene dynein light chain Tctex-type 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Exclusion of patched homolog 2 (PTCH2) as a candidate gene for alopecia X in Pomeranians and Keeshonden. Mausberg EM, et al. Vet Rec, 2008 Jul 26. PMID 18660523

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The lack of a role for patched homolog 2 mutations in canine alopecia X is reported.
    Title: Exclusion of patched homolog 2 (PTCH2) as a candidate gene for alopecia X in Pomeranians and Keeshonden.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables hedgehog family protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables hedgehog receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables smoothened binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
LOW QUALITY PROTEIN: protein patched homolog 2; protein patched homolog 2
Names
patched homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051819.1 Reference ROS_Cfam_1.0

    Range
    15643729..15659090
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038687883.1 → XP_038543811.1  protein patched homolog 2 isoform X8

    Conserved Domains (1) summary
    cl25655
    Location:24 → 568
    Patched; Patched family

  2. XM_038687882.1 → XP_038543810.1  protein patched homolog 2 isoform X7

    Conserved Domains (1) summary
    cl25655
    Location:24 → 762
    Patched; Patched family

  3. XM_038687877.1 → XP_038543805.1  protein patched homolog 2 isoform X2

    Conserved Domains (1) summary
    cl25655
    Location:24 → 1161
    Patched; Patched family

  4. XM_038687879.1 → XP_038543807.1  protein patched homolog 2 isoform X4

    Conserved Domains (1) summary
    cl25655
    Location:24 → 1151
    Patched; Patched family

  5. XM_038687881.1 → XP_038543809.1  protein patched homolog 2 isoform X6

    Conserved Domains (1) summary
    cl25655
    Location:24 → 931
    Patched; Patched family

  6. XM_038687876.1 → XP_038543804.1  protein patched homolog 2 isoform X1

    Conserved Domains (1) summary
    cl25655
    Location:24 → 1168
    Patched; Patched family

  7. XM_038687878.1 → XP_038543806.1  protein patched homolog 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0RL31, A0A8I3S5G8
    Related
    ENSCAFP00845035537.1, ENSCAFT00845045312.1
    Conserved Domains (1) summary
    TIGR00918
    Location:24 → 1142
    2A060602; The Eukaryotic (Putative) Sterol Transporter (EST) Family

  8. XM_038687880.1 → XP_038543808.1  protein patched homolog 2 isoform X5

    Conserved Domains (1) summary
    cl25655
    Location:1 → 1055
    Patched; Patched family

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049275.1 Alternate UMICH_Zoey_3.1

    Range
    15440572..15455919
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038495885.1 → XP_038351813.1  protein patched homolog 2 isoform X8

    Conserved Domains (1) summary
    cl25655
    Location:24 → 568
    Patched; Patched family

  2. XM_038495884.1 → XP_038351812.1  protein patched homolog 2 isoform X7

    Conserved Domains (1) summary
    cl25655
    Location:24 → 762
    Patched; Patched family

  3. XM_038495879.1 → XP_038351807.1  protein patched homolog 2 isoform X2

    Conserved Domains (1) summary
    cl25655
    Location:24 → 1161
    Patched; Patched family

  4. XM_038495881.1 → XP_038351809.1  protein patched homolog 2 isoform X4

    Conserved Domains (1) summary
    cl25655
    Location:24 → 1151
    Patched; Patched family

  5. XM_038495883.1 → XP_038351811.1  protein patched homolog 2 isoform X6

    Conserved Domains (1) summary
    cl25655
    Location:24 → 931
    Patched; Patched family

  6. XM_038495878.1 → XP_038351806.1  protein patched homolog 2 isoform X1

    Conserved Domains (1) summary
    cl25655
    Location:24 → 1168
    Patched; Patched family

  7. XM_038495880.1 → XP_038351808.1  protein patched homolog 2 isoform X3

    Conserved Domains (1) summary
    TIGR00918
    Location:24 → 1142
    2A060602; The Eukaryotic (Putative) Sterol Transporter (EST) Family

  8. XM_038495882.1 → XP_038351810.1  protein patched homolog 2 isoform X5

    Conserved Domains (1) summary
    cl25655
    Location:1 → 1055
    Patched; Patched family

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049756.1 Alternate UNSW_CanFamBas_1.0

    Range
    15508480..15523831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038622146.1 → XP_038478074.1  protein patched homolog 2 isoform X8

    Conserved Domains (1) summary
    cl25655
    Location:24 → 568
    Patched; Patched family

  2. XM_038622145.1 → XP_038478073.1  protein patched homolog 2 isoform X7

    Conserved Domains (1) summary
    cl25655
    Location:24 → 762
    Patched; Patched family

  3. XM_038622139.1 → XP_038478067.1  protein patched homolog 2 isoform X2

    Conserved Domains (1) summary
    cl25655
    Location:24 → 1161
    Patched; Patched family

  4. XM_038622141.1 → XP_038478069.1  protein patched homolog 2 isoform X4

    Conserved Domains (1) summary
    cl25655
    Location:24 → 1151
    Patched; Patched family

  5. XM_038622144.1 → XP_038478072.1  protein patched homolog 2 isoform X6

    Conserved Domains (1) summary
    cl25655
    Location:24 → 931
    Patched; Patched family

  6. XM_038622138.1 → XP_038478066.1  protein patched homolog 2 isoform X1

    Conserved Domains (1) summary
    cl25655
    Location:24 → 1168
    Patched; Patched family

  7. XM_038622140.1 → XP_038478068.1  protein patched homolog 2 isoform X3

    Conserved Domains (1) summary
    TIGR00918
    Location:24 → 1142
    2A060602; The Eukaryotic (Putative) Sterol Transporter (EST) Family

  8. XM_038622142.1 → XP_038478070.1  protein patched homolog 2 isoform X5

    Conserved Domains (1) summary
    cl25655
    Location:1 → 1055
    Patched; Patched family

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049236.1 Alternate UU_Cfam_GSD_1.0

    Range
    15581190..15596607
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038558255.1 → XP_038414183.1  LOW QUALITY PROTEIN: protein patched homolog 2 isoform X9

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006597.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    15608551..15623939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038451974.1 → XP_038307902.1  protein patched homolog 2 isoform X8

    Conserved Domains (1) summary
    cl25655
    Location:24 → 568
    Patched; Patched family

  2. XM_038451972.1 → XP_038307900.1  protein patched homolog 2 isoform X7

    Conserved Domains (1) summary
    cl25655
    Location:24 → 762
    Patched; Patched family

  3. XM_014119704.3 → XP_013975179.1  protein patched homolog 2 isoform X2

    Conserved Domains (1) summary
    cl25655
    Location:24 → 1161
    Patched; Patched family

  4. XM_005629081.4 → XP_005629138.1  protein patched homolog 2 isoform X4

    Conserved Domains (1) summary
    cl25655
    Location:24 → 1151
    Patched; Patched family

  5. XM_005629082.4 → XP_005629139.1  protein patched homolog 2 isoform X6

    See identical proteins and their annotated locations for XP_005629139.1

    Conserved Domains (1) summary
    cl25655
    Location:24 → 931
    Patched; Patched family

  6. XM_005629080.4 → XP_005629137.1  protein patched homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KX78
    Conserved Domains (1) summary
    cl25655
    Location:24 → 1168
    Patched; Patched family

  7. XM_539636.7 → XP_539636.3  protein patched homolog 2 isoform X3

    UniProtKB/TrEMBL
    A0A8P0SAB2
    Conserved Domains (1) summary
    TIGR00918
    Location:24 → 1142
    2A060602; The Eukaryotic (Putative) Sterol Transporter (EST) Family

  8. XM_022428025.2 → XP_022283733.1  protein patched homolog 2 isoform X5

    Conserved Domains (1) summary
    cl25655
    Location:1 → 1055
    Patched; Patched family
Nucleotide Protein
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