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CISH cytokine inducible SH2 containing protein [ Canis lupus familiaris (dog) ]

Gene ID: 484757, updated on 5-Mar-2024

Summary

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Official Symbol
CISHprovided by VGNC
Official Full Name
cytokine inducible SH2 containing proteinprovided by VGNC
Primary source
VGNC:VGNC:39281
See related
Ensembl:ENSCAFG00845020354
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See CISH in Genome Data Viewer
Location:
chromosome: 20
Exon count:
3
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 20 NC_051824.1 (39116466..39121847)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 20 NC_006602.4 (38681549..38686929)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 20 NC_049241.1 (39167907..39173288)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 20 NC_049280.1 (38484384..38489763)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 20 NC_049761.1 (38887993..38893364)

Chromosome 20 - NC_051824.1Genomic Context describing neighboring genes Neighboring gene MAPK activated protein kinase 3 Neighboring gene uncharacterized LOC102152043 Neighboring gene HemK methyltransferase family member 1 Neighboring gene chromosome 20 C3orf18 homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of phosphatidylinositol 3-kinase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cytokine-inducible SH2-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051824.1 Reference ROS_Cfam_1.0

    Range
    39116466..39121847
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038427654.1 → XP_038283582.1  cytokine-inducible SH2-containing protein

    UniProtKB/TrEMBL
    A0A8C0LDR1, A0A8C0SLV0, A0A8I3PD12
    Related
    ENSCAFP00845028053.1, ENSCAFT00845035853.1
    Conserved Domains (2) summary
    cd10718
    Location:77 → 164
    SH2_CIS; Src homology 2 (SH2) domain found in cytokine-inducible SH2-containing protein (CIS)
    cd03734
    Location:217 → 257
    SOCS_CIS1; SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like proteins. Together with the SOCS proteins, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. ...

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049280.1 Alternate UMICH_Zoey_3.1

    Range
    38484384..38489763
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038503341.1 → XP_038359269.1  cytokine-inducible SH2-containing protein

    Conserved Domains (2) summary
    cd10718
    Location:77 → 164
    SH2_CIS; Src homology 2 (SH2) domain found in cytokine-inducible SH2-containing protein (CIS)
    cd03734
    Location:217 → 257
    SOCS_CIS1; SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like proteins. Together with the SOCS proteins, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. ...

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049761.1 Alternate UNSW_CanFamBas_1.0

    Range
    38887993..38893364
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038630493.1 → XP_038486421.1  cytokine-inducible SH2-containing protein

    Conserved Domains (2) summary
    cd10718
    Location:77 → 164
    SH2_CIS; Src homology 2 (SH2) domain found in cytokine-inducible SH2-containing protein (CIS)
    cd03734
    Location:217 → 257
    SOCS_CIS1; SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like proteins. Together with the SOCS proteins, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. ...

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049241.1 Alternate UU_Cfam_GSD_1.0

    Range
    39167907..39173288
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038566340.1 → XP_038422268.1  cytokine-inducible SH2-containing protein

    UniProtKB/TrEMBL
    A0A8C0LDR1, A0A8C0SLV0, A0A8I3PD12
    Conserved Domains (2) summary
    cd10718
    Location:77 → 164
    SH2_CIS; Src homology 2 (SH2) domain found in cytokine-inducible SH2-containing protein (CIS)
    cd03734
    Location:217 → 257
    SOCS_CIS1; SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like proteins. Together with the SOCS proteins, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. ...

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006602.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    38681549..38686929
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_541873.7 → XP_541873.3  cytokine-inducible SH2-containing protein

    UniProtKB/TrEMBL
    A0A8C0LDR1, A0A8C0SLV0, A0A8I3PD12
    Conserved Domains (2) summary
    cd10718
    Location:77 → 164
    SH2_CIS; Src homology 2 (SH2) domain found in cytokine-inducible SH2-containing protein (CIS)
    cd03734
    Location:217 → 257
    SOCS_CIS1; SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like proteins. Together with the SOCS proteins, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. ...
Nucleotide Protein
Heading Accession and Version

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