U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SP1 Sp1 transcription factor [ Canis lupus familiaris (dog) ]

Gene ID: 486507, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
SP1provided by VGNC
Official Full Name
Sp1 transcription factorprovided by VGNC
Primary source
VGNC:VGNC:49654
See related
Ensembl:ENSCAFG00845019670
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See SP1 in Genome Data Viewer
Location:
chromosome: 27
Exon count:
7
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 27 NC_051831.1 (1804038..1848490, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 27 NC_006609.4 (44404740..44448820)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 27 NC_049248.1 (44805663..44849851)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 27 NC_049287.1 (1823470..1867184, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 27 NC_049768.1 (1807708..1852315, complement)

Chromosome 27 - NC_051831.1Genomic Context describing neighboring genes Neighboring gene proline rich 13 Neighboring gene anti-Mullerian hormone receptor type 2 Neighboring gene uncharacterized LOC111092798 Neighboring gene Sp7 transcription factor

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification of a prostaglandin-responsive element in the Na,K-ATPase beta 1 promoter that is regulated by cAMP and Ca2+. Evidence for an interactive role of cAMP regulatory element-binding protein and Sp1. Matlhagela K, et al. J Biol Chem, 2005 Jan 7. PMID 15485816
  2. Hyperosmolarity-induced up-regulation of claudin-4 mediated by NADPH oxidase-dependent H2O2 production and Sp1/c-Jun cooperation. Ikari A, et al. Biochim Biophys Acta, 2013 Dec. PMID 23816505
  3. Cell confluency-induced Stat3 activation regulates NHE3 expression by recruiting Sp1 and Sp3 to the proximal NHE3 promoter region during epithelial dome formation. Su HW, et al. Am J Physiol Cell Physiol, 2009 Jan. PMID 19064501, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. hyperosmolarity increases nuclear Sp1/c-Jun complex and the association of the complex with the Sp1 binding site, resulting in the segment-specific expression of claudin-4 in the kidney.
    Title: Hyperosmolarity-induced up-regulation of claudin-4 mediated by NADPH oxidase-dependent H2O2 production and Sp1/c-Jun cooperation.
  2. Cell confluency-induced Stat3 activation regulates NHE3 expression by recruiting Sp1 and Sp3 to the proximal NHE3 promoter region during epithelial dome formation.
    Title: Cell confluency-induced Stat3 activation regulates NHE3 expression by recruiting Sp1 and Sp3 to the proximal NHE3 promoter region during epithelial dome formation.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
transcription factor Sp1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051831.1 Reference ROS_Cfam_1.0

    Range
    1804038..1848490 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038438059.1 → XP_038293987.1  transcription factor Sp1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0PDR8, A0A8I3S186, A0A8P0SC80
    Related
    ENSCAFP00845027169.1, ENSCAFT00845034689.1
    Conserved Domains (4) summary
    sd00017
    Location:629 → 651
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:687 → 709
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:673 → 696
    zf-H2C2_2; Zinc-finger double domain
    cd22539
    Location:54 → 628
    SP1_N; N-terminal domain of transcription factor Specificity Protein (SP) 1

  2. XM_038438060.1 → XP_038293988.1  transcription factor Sp1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0L4D2, A0A8I3S186
    Conserved Domains (4) summary
    sd00017
    Location:622 → 644
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:680 → 702
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:666 → 689
    zf-H2C2_2; Zinc-finger double domain
    cd22539
    Location:47 → 621
    SP1_N; N-terminal domain of transcription factor Specificity Protein (SP) 1

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049287.1 Alternate UMICH_Zoey_3.1

    Range
    1823470..1867184 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038512760.1 → XP_038368688.1  transcription factor Sp1 isoform X1

    Conserved Domains (4) summary
    sd00017
    Location:629 → 651
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:687 → 709
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:673 → 696
    zf-H2C2_2; Zinc-finger double domain
    cd22539
    Location:54 → 628
    SP1_N; N-terminal domain of transcription factor Specificity Protein (SP) 1

  2. XM_038512761.1 → XP_038368689.1  transcription factor Sp1 isoform X2

    Conserved Domains (4) summary
    sd00017
    Location:622 → 644
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:680 → 702
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:666 → 689
    zf-H2C2_2; Zinc-finger double domain
    cd22539
    Location:47 → 621
    SP1_N; N-terminal domain of transcription factor Specificity Protein (SP) 1

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049768.1 Alternate UNSW_CanFamBas_1.0

    Range
    1807708..1852315 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038640518.1 → XP_038496446.1  transcription factor Sp1 isoform X1

    Conserved Domains (4) summary
    sd00017
    Location:629 → 651
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:687 → 709
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:673 → 696
    zf-H2C2_2; Zinc-finger double domain
    cd22539
    Location:54 → 628
    SP1_N; N-terminal domain of transcription factor Specificity Protein (SP) 1

  2. XM_038640519.1 → XP_038496447.1  transcription factor Sp1 isoform X2

    Conserved Domains (4) summary
    sd00017
    Location:622 → 644
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:680 → 702
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:666 → 689
    zf-H2C2_2; Zinc-finger double domain
    cd22539
    Location:47 → 621
    SP1_N; N-terminal domain of transcription factor Specificity Protein (SP) 1

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049248.1 Alternate UU_Cfam_GSD_1.0

    Range
    44805663..44849851
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038577785.1 → XP_038433713.1  transcription factor Sp1 isoform X1

    UniProtKB/TrEMBL
    A0A8I3S186

  2. XM_038577786.1 → XP_038433714.1  transcription factor Sp1 isoform X2

    UniProtKB/TrEMBL
    A0A8I3S186

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006609.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    44404740..44448820
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038460159.1 → XP_038316087.1  transcription factor Sp1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0PDR8, A0A8I3S186, A0A8P0SC80
    Conserved Domains (4) summary
    sd00017
    Location:629 → 651
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:687 → 709
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:673 → 696
    zf-H2C2_2; Zinc-finger double domain
    cd22539
    Location:54 → 628
    SP1_N; N-terminal domain of transcription factor Specificity Protein (SP) 1

  2. XM_014108420.3 → XP_013963895.2  transcription factor Sp1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0L4D2, A0A8I3S186
    Conserved Domains (4) summary
    sd00017
    Location:622 → 644
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:680 → 702
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:666 → 689
    zf-H2C2_2; Zinc-finger double domain
    cd22539
    Location:47 → 621
    SP1_N; N-terminal domain of transcription factor Specificity Protein (SP) 1
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.