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SIRT1 sirtuin 1 [ Canis lupus familiaris (dog) ]

Gene ID: 489012, updated on 5-Mar-2024

Summary

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Official Symbol
SIRT1provided by VGNC
Official Full Name
sirtuin 1provided by VGNC
Primary source
VGNC:VGNC:46183
See related
Ensembl:ENSCAFG00845001191
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
sirtuin-1
Orthologs
human mouse all
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Genomic context

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See SIRT1 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
12
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 4 NC_051808.1 (19454692..19486553)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 4 NC_006586.4 (19317273..19349181)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 4 NC_049225.1 (19901939..19934337)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 4 NC_049264.1 (19337295..19369150)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 4 NC_049745.1 (19559257..19591114)

Chromosome 4 - NC_051808.1Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1-like Neighboring gene tubulin alpha-1A chain-like Neighboring gene 60S ribosomal protein L7-like Neighboring gene HECT and RLD domain containing E3 ubiquitin protein ligase 4 Neighboring gene U6 spliceosomal RNA Neighboring gene myopalladin Neighboring gene atonal bHLH transcription factor 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Resveratrol-mediated SIRT-1 interactions with p300 modulate receptor activator of NF-kappaB ligand (RANKL) activation of NF-kappaB signaling and inhibit osteoclastogenesis in bone-derived cells. Shakibaei M, et al. J Biol Chem, 2011 Apr 1. PMID 21239502, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Resveratrol-mediated SIRT-1 interactions with p300 modulate receptor activator of NF-kappaB ligand (RANKL) activation of NF-kappaB signaling and inhibit osteoclastogenesis in bone-derived cells.
    Title: Resveratrol-mediated SIRT-1 interactions with p300 modulate receptor activator of NF-kappaB ligand (RANKL) activation of NF-kappaB signaling and inhibit osteoclastogenesis in bone-derived cells.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables NAD+ binding IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
NAD-dependent deacetylase sirtuin-1; NAD-dependent protein deacetylase sirtuin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051808.1 Reference ROS_Cfam_1.0

    Range
    19454692..19486553
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038662721.1 → XP_038518649.1  NAD-dependent protein deacetylase sirtuin-1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LS40, A0A8C0PXS3, A0A8I3ME48
    Conserved Domains (1) summary
    cd01408
    Location:250 → 485
    SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...

  2. XM_038662720.1 → XP_038518648.1  NAD-dependent protein deacetylase sirtuin-1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LS40, A0A8C0PXS3, A0A8I3ME48
    Related
    ENSCAFP00845001611.1, ENSCAFT00845002061.1
    Conserved Domains (1) summary
    cd01408
    Location:250 → 485
    SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...

  3. XM_038662722.1 → XP_038518650.1  NAD-dependent protein deacetylase sirtuin-1 isoform X2

    UniProtKB/TrEMBL
    A0A2Z5WQD9
    Conserved Domains (1) summary
    cd01408
    Location:62 → 297
    SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...

  4. XM_038662723.1 → XP_038518651.1  NAD-dependent protein deacetylase sirtuin-1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0PXT4, A0A8I3MJV3
    Related
    ENSCAFP00845001637.1, ENSCAFT00845002088.1
    Conserved Domains (1) summary
    cl00195
    Location:12 → 186
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049264.1 Alternate UMICH_Zoey_3.1

    Range
    19337295..19369150
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038473053.1 → XP_038328981.1  NAD-dependent protein deacetylase sirtuin-1 isoform X1

    Conserved Domains (1) summary
    cd01408
    Location:250 → 485
    SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...

  2. XM_038473052.1 → XP_038328980.1  NAD-dependent protein deacetylase sirtuin-1 isoform X1

    Conserved Domains (1) summary
    cd01408
    Location:250 → 485
    SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...

  3. XM_038473054.1 → XP_038328982.1  NAD-dependent protein deacetylase sirtuin-1 isoform X2

    Conserved Domains (1) summary
    cd01408
    Location:62 → 297
    SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...

  4. XM_038473055.1 → XP_038328983.1  NAD-dependent protein deacetylase sirtuin-1 isoform X3

    Conserved Domains (1) summary
    cl00195
    Location:12 → 186
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049745.1 Alternate UNSW_CanFamBas_1.0

    Range
    19559257..19591114
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038598418.1 → XP_038454346.1  NAD-dependent protein deacetylase sirtuin-1 isoform X1

    Conserved Domains (1) summary
    cd01408
    Location:250 → 485
    SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...

  2. XM_038598417.1 → XP_038454345.1  NAD-dependent protein deacetylase sirtuin-1 isoform X1

    Conserved Domains (1) summary
    cd01408
    Location:250 → 485
    SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...

  3. XM_038598419.1 → XP_038454347.1  NAD-dependent protein deacetylase sirtuin-1 isoform X2

    Conserved Domains (1) summary
    cd01408
    Location:62 → 297
    SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...

  4. XM_038598420.1 → XP_038454348.1  NAD-dependent protein deacetylase sirtuin-1 isoform X3

    Conserved Domains (1) summary
    cl00195
    Location:12 → 186
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049225.1 Alternate UU_Cfam_GSD_1.0

    Range
    19901939..19934337
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038534098.1 → XP_038390026.1  NAD-dependent protein deacetylase sirtuin-1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LS40, A0A8C0PXS3, A0A8I3ME48
    Conserved Domains (1) summary
    cd01408
    Location:250 → 485
    SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...

  2. XM_038534097.1 → XP_038390025.1  NAD-dependent protein deacetylase sirtuin-1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LS40, A0A8C0PXS3, A0A8I3ME48
    Conserved Domains (1) summary
    cd01408
    Location:250 → 485
    SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...

  3. XM_038534099.1 → XP_038390027.1  NAD-dependent protein deacetylase sirtuin-1 isoform X2

    UniProtKB/TrEMBL
    A0A2Z5WQD9
    Conserved Domains (1) summary
    cd01408
    Location:62 → 297
    SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...

  4. XM_038534100.1 → XP_038390028.1  NAD-dependent protein deacetylase sirtuin-1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0PXT4, A0A8I3MJV3
    Conserved Domains (1) summary
    cl00195
    Location:12 → 186
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006586.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    19317273..19349181
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038489791.1 → XP_038345719.1  NAD-dependent protein deacetylase sirtuin-1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LS40, A0A8P0SHY1
    Conserved Domains (1) summary
    cd01408
    Location:250 → 485
    SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...

  2. XM_546130.7 → XP_546130.3  NAD-dependent protein deacetylase sirtuin-1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LS40, A0A8P0SHY1
    Conserved Domains (1) summary
    cd01408
    Location:250 → 485
    SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...

  3. XM_005618933.3 → XP_005618990.1  NAD-dependent protein deacetylase sirtuin-1 isoform X2

    UniProtKB/TrEMBL
    A0A2Z5WQD9
    Conserved Domains (1) summary
    cd01408
    Location:62 → 297
    SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...

  4. XM_022417473.2 → XP_022273181.1  NAD-dependent protein deacetylase sirtuin-1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0PXT4, A0A8I3MJV3
    Conserved Domains (1) summary
    cl00195
    Location:12 → 186
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
Nucleotide Protein
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