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GIT1 GIT ArfGAP 1 [ Canis lupus familiaris (dog) ]

Gene ID: 491180, updated on 5-Mar-2024

Summary

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Official Symbol
GIT1provided by VGNC
Official Full Name
GIT ArfGAP 1provided by VGNC
Primary source
VGNC:VGNC:41229
See related
Ensembl:ENSCAFG00845011450
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See GIT1 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
22
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (44492902..44509385, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (42829811..42846296, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (43648051..43664538, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (43277271..43293743, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (43567974..43584445, complement)

Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene TAO kinase 1 Neighboring gene abhydrolase domain containing 15 Neighboring gene tumor protein p53 inducible protein 13 Neighboring gene ankyrin repeat domain 13B Neighboring gene coronin 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. EphA2 engages Git1 to suppress Arf6 activity modulating epithelial cell-cell contacts. Miura K, et al. Mol Biol Cell, 2009 Apr. PMID 19193766, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in brain development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ARF GTPase-activating protein GIT1
Names
G protein-coupled receptor kinase interactor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051813.1 Reference ROS_Cfam_1.0

    Range
    44492902..44509385 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038677570.1 → XP_038533498.1  ARF GTPase-activating protein GIT1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KEW3, A0A8C0PNV1
    Conserved Domains (6) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    cl28907
    Location:18 → 111
    ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
    pfam08518
    Location:337 → 365
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:647 → 763
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:418 → 482
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

  2. XM_038677571.1 → XP_038533499.1  ARF GTPase-activating protein GIT1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0KEW3, A0A8C0PNV1, A0A8I3NJR6, A0A8P0THE7
    Related
    ENSCAFP00845015976.1, ENSCAFT00845020383.1
    Conserved Domains (6) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    cd08846
    Location:1 → 111
    ArfGap_GIT1; GIT1 GTPase activating protein for Arf
    pfam08518
    Location:328 → 356
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:638 → 754
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:409 → 473
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

  3. XM_038677569.1 → XP_038533497.1  ARF GTPase-activating protein GIT1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KEW3, A0A8C0MXI9, A0A8C0PNV1, A0A8I3N9A3
    Related
    ENSCAFP00845015921.1, ENSCAFT00845020312.1
    Conserved Domains (6) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    cd08846
    Location:1 → 111
    ArfGap_GIT1; GIT1 GTPase activating protein for Arf
    pfam08518
    Location:337 → 365
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:647 → 763
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:418 → 482
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    43277271..43293743 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038486504.1 → XP_038342432.1  ARF GTPase-activating protein GIT1 isoform X2

    Conserved Domains (6) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    cl28907
    Location:18 → 111
    ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
    pfam08518
    Location:337 → 365
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:647 → 763
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:418 → 482
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

  2. XM_038486505.1 → XP_038342433.1  ARF GTPase-activating protein GIT1 isoform X3

    Conserved Domains (6) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    cd08846
    Location:1 → 111
    ArfGap_GIT1; GIT1 GTPase activating protein for Arf
    pfam08518
    Location:328 → 356
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:638 → 754
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:409 → 473
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

  3. XM_038486503.1 → XP_038342431.1  ARF GTPase-activating protein GIT1 isoform X1

    Conserved Domains (6) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    cd08846
    Location:1 → 111
    ArfGap_GIT1; GIT1 GTPase activating protein for Arf
    pfam08518
    Location:337 → 365
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:647 → 763
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:418 → 482
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    43567974..43584445 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038612298.1 → XP_038468226.1  ARF GTPase-activating protein GIT1 isoform X2

    Conserved Domains (6) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    cl28907
    Location:18 → 111
    ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
    pfam08518
    Location:337 → 365
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:647 → 763
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:418 → 482
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

  2. XM_038612299.1 → XP_038468227.1  ARF GTPase-activating protein GIT1 isoform X3

    Conserved Domains (6) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    cd08846
    Location:1 → 111
    ArfGap_GIT1; GIT1 GTPase activating protein for Arf
    pfam08518
    Location:328 → 356
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:638 → 754
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:409 → 473
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

  3. XM_038612297.1 → XP_038468225.1  ARF GTPase-activating protein GIT1 isoform X1

    Conserved Domains (6) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    cd08846
    Location:1 → 111
    ArfGap_GIT1; GIT1 GTPase activating protein for Arf
    pfam08518
    Location:337 → 365
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:647 → 763
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:418 → 482
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

    Range
    43648051..43664538 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038548349.1 → XP_038404277.1  ARF GTPase-activating protein GIT1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KEW3, A0A8C0PNV1
    Conserved Domains (6) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    cl28907
    Location:18 → 111
    ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
    pfam08518
    Location:337 → 365
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:647 → 763
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:418 → 482
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

  2. XM_038548350.1 → XP_038404278.1  ARF GTPase-activating protein GIT1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0KEW3, A0A8C0PNV1, A0A8I3NJR6, A0A8P0THE7
    Conserved Domains (6) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    cd08846
    Location:1 → 111
    ArfGap_GIT1; GIT1 GTPase activating protein for Arf
    pfam08518
    Location:328 → 356
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:638 → 754
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:409 → 473
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

  3. XM_038548348.1 → XP_038404276.1  ARF GTPase-activating protein GIT1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KEW3, A0A8C0MXI9, A0A8C0PNV1, A0A8I3N9A3
    Conserved Domains (6) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    cd08846
    Location:1 → 111
    ArfGap_GIT1; GIT1 GTPase activating protein for Arf
    pfam08518
    Location:337 → 365
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:647 → 763
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:418 → 482
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    42829811..42846296 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038611614.1 → XP_038467542.1  ARF GTPase-activating protein GIT1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KEW3, A0A8C0PNV1
    Conserved Domains (6) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    cl28907
    Location:18 → 111
    ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
    pfam08518
    Location:337 → 365
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:647 → 763
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:418 → 482
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

  2. XM_038611624.1 → XP_038467552.1  ARF GTPase-activating protein GIT1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0KEW3, A0A8C0PNV1, A0A8I3NJR6, A0A8P0THE7
    Conserved Domains (6) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    cd08846
    Location:1 → 111
    ArfGap_GIT1; GIT1 GTPase activating protein for Arf
    pfam08518
    Location:328 → 356
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:638 → 754
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:409 → 473
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

  3. XM_038611604.1 → XP_038467532.1  ARF GTPase-activating protein GIT1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KEW3, A0A8C0MXI9, A0A8C0PNV1, A0A8I3N9A3
    Conserved Domains (6) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    cd08846
    Location:1 → 111
    ArfGap_GIT1; GIT1 GTPase activating protein for Arf
    pfam08518
    Location:337 → 365
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:647 → 763
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:418 → 482
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
Nucleotide Protein
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