numbl NUMB like endocytic adaptor protein [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: numblprovided by ZNC
Official Full Name: NUMB like endocytic adaptor proteinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-051113-340
See related: Ensembl:ENSDARG00000101949 AllianceGenome:ZFIN:ZDB-GENE-051113-340
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: z-numb; zgc:123031
Summary: Acts upstream of or within determination of left/right symmetry; negative regulation of Notch signaling pathway; and primitive erythrocyte differentiation. Located in cytoplasm. Is expressed in immature eye; integument; musculature system; nervous system; and pleuroperitoneal region. Orthologous to human NUMBL (NUMB like endocytic adaptor protein). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (14435852..14552101, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (14499888..14616144, complement)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

z-numb was essential for left-right field formation and maintenance in zebrafish
Title: Zebrafish Numb homologue: phylogenetic evolution and involvement in regulation of left-right asymmetry.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within determination of left/right symmetry	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within primitive erythrocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within primitive erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: numb-like protein

Names: numb homolog-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012375.3 → NP_001012375.3 numb-like protein

Status: VALIDATED

Source sequence(s)

CR318657, CU019550

UniProtKB/TrEMBL

A0A0R4IDU4, A0A8M1N483

Related

ENSDARP00000130879.1, ENSDART00000171169.2

Conserved Domains (2) summary

cd01268
Location:23 → 157

PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

pfam06311
Location:238 → 322

NumbF; NUMB domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007126.7 Reference GRCz11 Primary Assembly

Range

14435852..14552101 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005173378.4 → XP_005173435.1 numb-like protein isoform X1

UniProtKB/TrEMBL

A0A286Y8T8, A0A8M2BKQ5

Related

ENSDARP00000143561.1, ENSDART00000179368.2

Conserved Domains (2) summary

cd01268
Location:45 → 179

PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

pfam06311
Location:260 → 344

NumbF; NUMB domain